Being able to synthesise this molecule in bulk is important because it is a precursor in the synthesis of the triazolopyrazine core for series four amides (see http://malaria.ourexperiment.org/the_osm_blog/8173/post.html for amide synthetic plan).
I’m following the method used by Eduvie Omene:
Are these procedures from the literature Eduvie? I found a paper using your method for the synthesis of OSM-S-148 and OSM-S-149 (DOI: 10.1021/jm201045m, see p. 7688).
The ELN entries for this synthesis can be found here:
Hopefully this will be finished in two weeks time.
Nice post Inga - Eduvie (@PatrickThomson), if you have followed literature procedures please pop in the references to your ELN entries. We also need to discuss OSM-E numbers.
OK, so if your melting point is OK and your NMR is fine, are we able to close this Issue, @IngaTopolnicki ?
The melting point wasn’t as great as I’d hoped 151.7 - 153.3 °C compared to commercial m.p. 154.8 - 158.2 °C. But I’ll still close the issue because the NMR looks good and I think the product is still pure enough to be used for further reactions.