diff --git a/Jenkinsfile b/Jenkinsfile
deleted file mode 100644
index af7968e71ead2..0000000000000
--- a/Jenkinsfile
+++ /dev/null
@@ -1,75 +0,0 @@
-#!/usr/bin/env groovy
-
-// The stages we run one by one
-// Please don't add more than 2 items in a single stage; this hurts performance
-def ci_stages = [
-    "Checkers": [
-        "commit-checker": "openttd/compile-farm-ci:commit-checker",
-    ],
-    "Compilers": [
-        "linux-amd64-gcc-6": "openttd/compile-farm-ci:linux-amd64-gcc-6",
-        "linux-amd64-clang-3.8": "openttd/compile-farm-ci:linux-amd64-clang-3.8",
-    ],
-    "Archs": [
-        "linux-i386-gcc-6": "openttd/compile-farm-ci:linux-i386-gcc-6",
-    ],
-    "OS": [
-        "osx-10.9": "openttd/compile-farm-ci:osx-10.9",
-    ],
-]
-
-def generateStage(targets) {
-    return targets.collectEntries{ key, target ->
-        ["${key}": generateCI(key, target)]
-    }
-}
-
-def generateCI(display_name, image_name) {
-    return {
-        githubNotify context: 'openttd/' + display_name, description: 'This commit is being built', status: 'PENDING'
-
-        try {
-            dir("${display_name}") {
-                unstash "source"
-
-                docker.image("${image_name}").pull()
-                docker.image("${image_name}").withRun("--volumes-from ${hostname} --workdir " + pwd()) { c ->
-                    sh "docker logs --follow ${c.id}; exit `docker wait ${c.id}`"
-                }
-            }
-
-            githubNotify context: 'openttd/' + display_name, description: 'The commit looks good', status: 'SUCCESS'
-        }
-        catch (error) {
-            githubNotify context: 'openttd/' + display_name, description: 'The commit cannot be built', status: 'FAILURE'
-            throw error
-        }
-    }
-}
-
-node {
-    ansiColor('xterm') {
-        stage("Checkout") {
-            checkout scm
-
-            // Ensure user.email and user.name is set, otherwise rebase cannot work
-            sh "git config user.email 'info@openttd.org'"
-            sh "git config user.name 'OpenTTD CI'"
-
-            // Ensure we also have origin/master available
-            sh "git fetch --no-tags origin master:refs/remotes/origin/master"
-
-            // Try to rebase to origin/master; if this fails, fail the CI
-            sh "git rebase origin/master"
-
-            stash name: "source", useDefaultExcludes: false
-        }
-
-        ci_stages.each { ci_stage ->
-            stage(ci_stage.key) {
-                parallel generateStage(ci_stage.value)
-            }
-        }
-    }
-}
-
diff --git a/azure-pipelines-ci.yml b/azure-pipelines-ci.yml
new file mode 100644
index 0000000000000..a630d14bcc6e7
--- /dev/null
+++ b/azure-pipelines-ci.yml
@@ -0,0 +1,96 @@
+trigger: none
+pr:
+- master
+
+jobs:
+- job: windows
+  displayName: 'Windows'
+  pool:
+    vmImage: 'VS2017-Win2016'
+
+  strategy:
+    matrix:
+      Win32:
+        BuildPlatform: 'Win32'
+      Win64:
+        BuildPlatform: 'x64'
+
+  steps:
+  # Rebase to origin/master for every PR. This means users don't have to
+  # rebase every time master changes. As long as the PR applies cleanly, we
+  # will validate it.
+  - script: git rebase origin/master
+    displayName: 'Rebase to master'
+  - task: DownloadBuildArtifacts@0
+    displayName: 'Download dependencies'
+    inputs:
+      buildType: specific
+      project: 'a5bed441-f5da-4930-a0e3-8c246e953bf7'
+      pipeline: 3
+      artifactName: 'windows-dependencies'
+      downloadPath: '$(Build.ArtifactStagingDirectory)'
+  - script: $(Build.ArtifactStagingDirectory)\windows-dependencies\vcpkg.exe integrate install
+    displayName: 'Install dependencies'
+  - task: VSBuild@1
+    displayName: 'Build'
+    inputs:
+      solution: 'projects/openttd_vs141.sln'
+      platform: $(BuildPlatform)
+      configuration: Release
+      maximumCpuCount: true
+  # Running the regression is currently not possibe via MSVC (console is not redirected)
+
+- job: linux
+  displayName: 'Linux'
+  pool:
+    vmImage: 'ubuntu-16.04'
+
+  strategy:
+    matrix:
+      commit-checker: {}
+      linux-amd64-clang-3.8: {}
+      linux-amd64-gcc-6: {}
+      linux-i386-gcc-6: {}
+
+  steps:
+  # Rebase to origin/master for every PR. This means users don't have to
+  # rebase every time master changes. As long as the PR applies cleanly, we
+  # will validate it.
+  - script: git rebase origin/master
+    displayName: 'Rebase to master'
+  - task: Docker@1
+    displayName: 'Build and test'
+    inputs:
+      command: 'Run an image'
+      imageName: openttd/compile-farm-ci:$(Agent.JobName)
+      volumes: '$(Build.SourcesDirectory):$(Build.SourcesDirectory)'
+      workingDirectory: '$(Build.SourcesDirectory)'
+      runInBackground: false
+
+- job: macos
+  displayName: 'MacOS'
+  pool:
+    vmImage: 'macOS-10.13'
+
+  steps:
+  # Rebase to origin/master for every PR. This means users don't have to
+  # rebase every time master changes. As long as the PR applies cleanly, we
+  # will validate it.
+  - script: git rebase origin/master
+    displayName: 'Rebase to master'
+  - script: HOMEBREW_NO_AUTO_UPDATE=1 brew install pkg-config lzo xz libpng
+    displayName: 'Install dependencies'
+  - bash: |
+      set -ex
+      mkdir -p ~/Documents/OpenTTD/baseset
+      cd ~/Documents/OpenTTD/baseset
+      wget https://binaries.openttd.org/extra/opengfx/0.5.2/opengfx-0.5.2-all.zip
+      unzip opengfx-0.5.2-all.zip
+      rm -f opengfx-0.5.2-all.zip
+    displayName: 'Install OpenGFX'
+  - script: './configure PKG_CONFIG_PATH=/usr/local/lib/pkgconfig --enable-static'
+    displayName: 'Configure'
+  - script: 'make -j2'
+    displayName: 'Build'
+  - script: 'make regression'
+    displayName: 'Test'