diff --git a/bin/resources/GameIndex.yaml b/bin/resources/GameIndex.yaml
index 74d38a600dc85..c004166057a3f 100644
--- a/bin/resources/GameIndex.yaml
+++ b/bin/resources/GameIndex.yaml
@@ -26683,6 +26683,7 @@ SLES-82009:
     - InstantDMAHack # Fixes broken half-bottom artifacts.
   gsHWFixes:
     roundSprite: 2 # Fixes font artifacts.
+    autoFlush: 1 # Fixes depth of field blur.
     recommendedBlendingLevel: 3 # Fixes broken skin colour on Vlad and others.
 SLES-82010:
   name: "Metal Gear Solid 2, Document of"
@@ -28861,6 +28862,7 @@ SLKA-35001:
     - InstantDMAHack # Fixes broken half-bottom artifacts.
   gsHWFixes:
     roundSprite: 2 # Fixes font artifacts.
+    autoFlush: 1 # Fixes depth of field blur.
     recommendedBlendingLevel: 3 # Fixes broken skin colour on Vlad and others.
 SLKA-35003:
   name: "Sakura Taisen - Atsuki Chishioni"
@@ -45749,6 +45751,7 @@ SLPM-67002:
     - InstantDMAHack # Fixes broken half-bottom artifacts.
   gsHWFixes:
     roundSprite: 2 # Fixes font artifacts.
+    autoFlush: 1 # Fixes depth of field blur.
     recommendedBlendingLevel: 3 # Fixes broken skin colour on Vlad and others.
 SLPM-67003:
   name: サクラ大戦 〜熱き血潮に〜
@@ -45789,6 +45792,7 @@ SLPM-67008:
     - InstantDMAHack # Fixes broken half-bottom artifacts.
   gsHWFixes:
     roundSprite: 2 # Fixes font artifacts.
+    autoFlush: 1 # Fixes depth of field blur.
     recommendedBlendingLevel: 3 # Fixes broken skin colour on Vlad and others.
 SLPM-67009:
   name: サクラ大戦V 〜さらば愛しき人よ〜
@@ -46771,6 +46775,7 @@ SLPM-74901:
     - InstantDMAHack # Fixes broken half-bottom artifacts.
   gsHWFixes:
     roundSprite: 2 # Fixes font artifacts.
+    autoFlush: 1 # Fixes depth of field blur.
     recommendedBlendingLevel: 3 # Fixes broken skin colour on Vlad and others.
 SLPM-84075:
   name: "Anubis Zone of Enders Special Edition [Konami Dendou Selection]"
@@ -57718,6 +57723,7 @@ SLUS-20554:
     - InstantDMAHack # Fixes broken half-bottom artifacts.
   gsHWFixes:
     roundSprite: 2 # Fixes font artifacts.
+    autoFlush: 1 # Fixes depth of field blur.
     recommendedBlendingLevel: 3 # Fixes broken skin colour on Vlad and others.
 SLUS-20555:
   name: "Reel Fishing 3"