Alzheimer’s Disease Capture Panel Data Release

tkerelska edited this page Sep 20, 2017 · 2 revisions

SMRT Sequencing data from an Alzheimer’s Disease (AD) targeted enrichment experiment. A custom 35 gene panel containing candidate AD genes was designed in collaboration with IDT using xGen Lockdown Probes. A range of variants including SNPs, insertions and deletions were detected with long-read sequencing of a ~7 KB capture of genomic DNA isolated from brain and skeletal muscle of two AD subjects. Furthermore, phased alleles could be distinguished by leveraging contiguous multi-kilobase reads and heterozygous SNPs. This release contains only the genomic capture sequencing data presented in the 2017 AGBT Poster: “A method for the identification of variants in Alzheimer’s disease candidate genes and transcripts using hybridization capture combined with long-read sequencing.” (http://www.pacb.com/proceedings/a-method-for-the-identification-of-variants-in-alzheimers-disease-candidate-genes-and-transcripts-using-hybridization-capture-combined-with-long-read-sequencing/).

Download Data: https://downloads.pacbcloud.com/public/dataset/AlzheimersDiseaseCapturePanel/

Phasing Consensus Analysis for Targeted Sequencing is available to analyze capture data sets and generate phased consensus allelic sequences ((https://github.com/PacificBiosciences/targeted-phasing-consensus).

Clone this wiki locally
You can’t perform that action at this time.
You signed in with another tab or window. Reload to refresh your session. You signed out in another tab or window. Reload to refresh your session.
Press h to open a hovercard with more details.