diff --git a/perl.h b/perl.h
index 917ed5fcbb31..4fd1836cfe4d 100644
--- a/perl.h
+++ b/perl.h
@@ -3880,6 +3880,8 @@ intrinsic function, see its documents for more details.
 
 #ifdef DEBUGGING
 #  define ASSUME(x) assert(x)
+#elif __has_builtin(__builtin_assume)
+#  define ASSUME(x)  __builtin_assume(x)
 #elif defined(_MSC_VER)
 #  define ASSUME(x) __assume(x)
 #elif defined(__ARMCC_VERSION) /* untested */