Lithogen is a program that can be run from the command line or it can be hooked into the standard Visual Studio build process.
Lithogen is usable out of the box, but is also very extensible: the build pipeline can be extended using either C# or node.
Try "Lithogen.exe --fullhelp" to see the full help, or read it here https://github.com/PhilipDaniels/Lithogen/blob/master/src/Lithogen.Core/CommandLine/Lithogen.usage.txt
Websites are based on the ASP.Net MVC folder structure, but using the HTML5 boilerplate project, which gives you a great starting point for building modern, mobile-friendly websites. HTML5 boilerplate also gives you jQuery, Modernizr and Normalize.css and Google Analytics.
Uses ServiceStack/Bundler https://github.com/ServiceStack/Bundler to compile, minify and combine your less, sass, stylus, css, coffeescript, livescript and js files.
Ships with a working copy of node.exe and npm, making it easy to extend the build process with node modules.