diff --git a/src/handlers/handlerUtils.ts b/src/handlers/handlerUtils.ts
index 92e9c4bf..363a0f44 100644
--- a/src/handlers/handlerUtils.ts
+++ b/src/handlers/handlerUtils.ts
@@ -34,6 +34,7 @@ import {
 import { env } from 'hono/adapter';
 import { OpenAIChatCompleteJSONToStreamResponseTransform } from '../providers/openai/chatComplete';
 import { OpenAICompleteJSONToStreamResponseTransform } from '../providers/openai/complete';
+import { getRuntimeKey } from 'hono/adapter';
 
 /**
  * Constructs the request options for the API call.
@@ -946,6 +947,9 @@ export function updateResponseHeaders(
     // Brotli compression causes errors at runtime, removing the header in that case
     response.headers.delete('content-encoding');
   }
+  if (getRuntimeKey() == 'node') {
+    response.headers.delete('content-encoding');
+  }
 
   // Delete content-length header to avoid conflicts with hono compress middleware
   // workerd environment handles this authomatically
diff --git a/src/index.ts b/src/index.ts
index 7573f8e9..f852f67e 100644
--- a/src/index.ts
+++ b/src/index.ts
@@ -33,7 +33,7 @@ const app = new Hono();
 
 app.use('*', (c, next) => {
   const runtime = getRuntimeKey();
-  if (runtime !== 'lagon' && runtime !== 'workerd') {
+  if (runtime !== 'lagon' && runtime !== 'workerd' && runtime !== 'node') {
     return compress()(c, next);
   }
   return next();