diff --git a/docs/source/data.rst b/docs/source/data.rst
index 0ab64edb7b..e8c68de853 100644
--- a/docs/source/data.rst
+++ b/docs/source/data.rst
@@ -21,6 +21,12 @@ Generic Interfaces
   :members:
   :special-members: __next__
 
+`DatasetFunc`
+~~~~~~~~~~~~~
+.. autoclass:: DatasetFunc
+  :members:
+  :special-members: __next__
+
 `ShuffleBuffer`
 ~~~~~~~~~~~~~~~
 .. autoclass:: ShuffleBuffer
diff --git a/monai/data/__init__.py b/monai/data/__init__.py
index e7fa2b3107..b12a307663 100644
--- a/monai/data/__init__.py
+++ b/monai/data/__init__.py
@@ -17,6 +17,7 @@
     CacheNTransDataset,
     CSVDataset,
     Dataset,
+    DatasetFunc,
     LMDBDataset,
     NPZDictItemDataset,
     PersistentDataset,
diff --git a/monai/data/dataset.py b/monai/data/dataset.py
index 38371f384b..ccd831ee0f 100644
--- a/monai/data/dataset.py
+++ b/monai/data/dataset.py
@@ -97,6 +97,56 @@ def __getitem__(self, index: Union[int, slice, Sequence[int]]):
         return self._transform(index)
 
 
+class DatasetFunc(Dataset):
+    """
+    Execute function on the input dataset and leverage the output to act as a new Dataset.
+    It can be used to load / fetch the basic dataset items, like the list of `image, label` paths.
+    Or chain together to execute more complicated logic, like `partition_dataset`, `resample_datalist`, etc.
+    The `data` arg of `Dataset` will be applied to the first arg of callable `func`.
+    Usage example::
+
+        data_list = DatasetFunc(
+            data="path to file",
+            func=monai.data.load_decathlon_datalist,
+            data_list_key="validation",
+            base_dir="path to base dir",
+        )
+        # partition dataset for every rank
+        data_partition = DatasetFunc(
+            data=data_list,
+            func=lambda **kwargs: monai.data.partition_dataset(**kwargs)[torch.distributed.get_rank()],
+            num_partitions=torch.distributed.get_world_size(),
+        )
+        dataset = Dataset(data=data_partition, transform=transforms)
+
+    Args:
+        data: input data for the func to process, will apply to `func` as the first arg.
+        func: callable function to generate dataset items.
+        kwargs: other arguments for the `func` except for the first arg.
+
+    """
+
+    def __init__(self, data: Any, func: Callable, **kwargs) -> None:
+        super().__init__(data=None, transform=None)  # type:ignore
+        self.src = data
+        self.func = func
+        self.kwargs = kwargs
+        self.reset()
+
+    def reset(self, data: Optional[Any] = None, func: Optional[Callable] = None, **kwargs):
+        """
+        Reset the dataset items with specified `func`.
+
+        Args:
+            data: if not None, execute `func` on it, default to `self.src`.
+            func: if not None, execute the `func` with specified `kwargs`, default to `self.func`.
+            kwargs: other arguments for the `func` except for the first arg.
+
+        """
+        src = self.src if data is None else data
+        self.data = self.func(src, **self.kwargs) if func is None else func(src, **kwargs)
+
+
 class PersistentDataset(Dataset):
     """
     Persistent storage of pre-computed values to efficiently manage larger than memory dictionary format data,
diff --git a/tests/test_dataset_func.py b/tests/test_dataset_func.py
new file mode 100644
index 0000000000..b3f6b95403
--- /dev/null
+++ b/tests/test_dataset_func.py
@@ -0,0 +1,52 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import json
+import os
+import tempfile
+import unittest
+
+from monai.data import Dataset, DatasetFunc, load_decathlon_datalist, partition_dataset
+
+
+class TestDatasetFunc(unittest.TestCase):
+    def test_seg_values(self):
+        with tempfile.TemporaryDirectory() as tempdir:
+            # prepare test datalist file
+            test_data = {
+                "name": "Spleen",
+                "description": "Spleen Segmentation",
+                "labels": {"0": "background", "1": "spleen"},
+                "training": [
+                    {"image": "spleen_19.nii.gz", "label": "spleen_19.nii.gz"},
+                    {"image": "spleen_31.nii.gz", "label": "spleen_31.nii.gz"},
+                ],
+                "test": ["spleen_15.nii.gz", "spleen_23.nii.gz"],
+            }
+            json_str = json.dumps(test_data)
+            file_path = os.path.join(tempdir, "test_data.json")
+            with open(file_path, "w") as json_file:
+                json_file.write(json_str)
+
+            data_list = DatasetFunc(
+                data=file_path, func=load_decathlon_datalist, data_list_key="training", base_dir=tempdir
+            )
+            # partition dataset for train / validation
+            data_partition = DatasetFunc(
+                data=data_list, func=lambda x, **kwargs: partition_dataset(x, **kwargs)[0], num_partitions=2
+            )
+            dataset = Dataset(data=data_partition, transform=None)
+            self.assertEqual(dataset[0]["image"], os.path.join(tempdir, "spleen_19.nii.gz"))
+            self.assertEqual(dataset[0]["label"], os.path.join(tempdir, "spleen_19.nii.gz"))
+
+
+if __name__ == "__main__":
+    unittest.main()
diff --git a/tests/test_scale_intensity_range_percentilesd.py b/tests/test_scale_intensity_range_percentilesd.py
index ac2118d99f..0fcda21feb 100644
--- a/tests/test_scale_intensity_range_percentilesd.py
+++ b/tests/test_scale_intensity_range_percentilesd.py
@@ -35,7 +35,7 @@ def test_scaling(self):
             scaler = ScaleIntensityRangePercentilesd(
                 keys=data.keys(), lower=lower, upper=upper, b_min=b_min, b_max=b_max
             )
-            assert_allclose(p(expected), scaler(data)["img"])
+            assert_allclose(p(expected), scaler(data)["img"], rtol=1e-4)
 
     def test_relative_scaling(self):
         img = self.imt