diff --git a/monai/utils/misc.py b/monai/utils/misc.py
index 4fe63744fd..eae0580696 100644
--- a/monai/utils/misc.py
+++ b/monai/utils/misc.py
@@ -251,6 +251,10 @@ def set_determinism(
         for func in additional_settings:
             func(seed)
 
+    if torch.backends.flags_frozen():
+        warnings.warn("PyTorch global flag support of backends is disabled, enable it to set global `cudnn` flags.")
+        torch.backends.__allow_nonbracketed_mutation_flag = True
+
     if seed is not None:
         torch.backends.cudnn.deterministic = True
         torch.backends.cudnn.benchmark = False
diff --git a/tests/test_set_determinism.py b/tests/test_set_determinism.py
index 31b3254f5b..7d6c54909d 100644
--- a/tests/test_set_determinism.py
+++ b/tests/test_set_determinism.py
@@ -40,6 +40,8 @@ def test_values(self):
         self.assertEqual(seed, get_seed())
         a = np.random.randint(seed)
         b = torch.randint(seed, (1,))
+        # tset when global flag support is disabled
+        torch.backends.disable_global_flags()
         set_determinism(seed=seed)
         c = np.random.randint(seed)
         d = torch.randint(seed, (1,))