diff --git a/monai/networks/blocks/transformerblock.py b/monai/networks/blocks/transformerblock.py
index b93d81bdef..f597221c18 100644
--- a/monai/networks/blocks/transformerblock.py
+++ b/monai/networks/blocks/transformerblock.py
@@ -78,15 +78,16 @@ def __init__(
         self.norm2 = nn.LayerNorm(hidden_size)
         self.with_cross_attention = with_cross_attention
 
-        self.norm_cross_attn = nn.LayerNorm(hidden_size)
-        self.cross_attn = CrossAttentionBlock(
-            hidden_size=hidden_size,
-            num_heads=num_heads,
-            dropout_rate=dropout_rate,
-            qkv_bias=qkv_bias,
-            causal=False,
-            use_flash_attention=use_flash_attention,
-        )
+        if with_cross_attention:
+            self.norm_cross_attn = nn.LayerNorm(hidden_size)
+            self.cross_attn = CrossAttentionBlock(
+                hidden_size=hidden_size,
+                num_heads=num_heads,
+                dropout_rate=dropout_rate,
+                qkv_bias=qkv_bias,
+                causal=False,
+                use_flash_attention=use_flash_attention,
+            )
 
     def forward(
         self, x: torch.Tensor, context: torch.Tensor | None = None, attn_mask: torch.Tensor | None = None
diff --git a/tests/networks/blocks/test_transformerblock.py b/tests/networks/blocks/test_transformerblock.py
index b977a38e73..ea5706f1a4 100644
--- a/tests/networks/blocks/test_transformerblock.py
+++ b/tests/networks/blocks/test_transformerblock.py
@@ -53,6 +53,26 @@ def test_ill_arg(self):
         with self.assertRaises(ValueError):
             TransformerBlock(hidden_size=622, num_heads=8, mlp_dim=3072, dropout_rate=0.4)
 
+    @skipUnless(has_einops, "Requires einops")
+    def test_no_cross_attention_params_when_disabled(self):
+        """When with_cross_attention=False, no cross-attention parameters should be registered."""
+        block = TransformerBlock(hidden_size=128, mlp_dim=256, num_heads=4, with_cross_attention=False)
+        param_names = {n for n, _ in block.named_parameters()}
+        self.assertFalse(
+            any("cross_attn" in n or "norm_cross_attn" in n for n in param_names),
+            f"Unexpected cross-attention parameters found: {[n for n in param_names if 'cross' in n]}",
+        )
+
+    @skipUnless(has_einops, "Requires einops")
+    def test_cross_attention_params_when_enabled(self):
+        """When with_cross_attention=True, cross-attention parameters should be registered."""
+        block = TransformerBlock(hidden_size=128, mlp_dim=256, num_heads=4, with_cross_attention=True)
+        param_names = {n for n, _ in block.named_parameters()}
+        self.assertTrue(
+            any("cross_attn" in n for n in param_names),
+            "Expected cross-attention parameters not found when with_cross_attention=True",
+        )
+
     @skipUnless(has_einops, "Requires einops")
     def test_access_attn_matrix(self):
         # input format