diff --git a/qiskit/passmanager/passmanager.py b/qiskit/passmanager/passmanager.py
index fa664ef7ccf..ba416dfb063 100644
--- a/qiskit/passmanager/passmanager.py
+++ b/qiskit/passmanager/passmanager.py
@@ -47,6 +47,8 @@ def __init__(
         """
         self._tasks = []
         self.max_iteration = max_iteration
+        # This empty property set never gets used; it gets overridden at the completion of a
+        # workflow run.
         self.property_set = PropertySet()
 
         if tasks:
@@ -287,14 +289,22 @@ def _run_workflow(
         input_program=program,
         **kwargs,
     )
-    passmanager_ir, _ = flow_controller.execute(
+    passmanager_ir, final_state = flow_controller.execute(
         passmanager_ir=passmanager_ir,
         state=PassManagerState(
             workflow_status=initial_status,
-            property_set=pass_manager.property_set,
+            property_set=PropertySet(),
         ),
         callback=kwargs.get("callback", None),
     )
+    # The `property_set` has historically been returned as a mutable attribute on `PassManager`
+    # This makes us non-reentrant (though `PassManager` would be dependent on its internal tasks to
+    # be re-entrant if that was required), but is consistent with previous interfaces.  We're still
+    # safe to be called in a serial loop, again assuming internal tasks are re-runnable.  The
+    # conversion to the backend language is also allowed to use the property set, so it must be set
+    # before calling it.
+    pass_manager.property_set = final_state.property_set
+
     out_program = pass_manager._passmanager_backend(
         passmanager_ir=passmanager_ir,
         in_program=program,
diff --git a/releasenotes/notes/fix-passmanager-reuse-151877e1905d49df.yaml b/releasenotes/notes/fix-passmanager-reuse-151877e1905d49df.yaml
new file mode 100644
index 00000000000..551d45f0ae8
--- /dev/null
+++ b/releasenotes/notes/fix-passmanager-reuse-151877e1905d49df.yaml
@@ -0,0 +1,7 @@
+---
+fixes:
+  - |
+    :meth:`.BasePassManager.run` will no longer leak the previous :class:`.PropertySet` into new
+    workflows when called more than once.  Previously, the same :class:`.PropertySet` as before
+    would be used to initialize follow-on runs, which could mean that invalid property information
+    was being given to tasks.  The behavior now matches that of Qiskit 0.44.  Fixed `#11784 <https://github.com/Qiskit/qiskit/issues/11784>`__.
diff --git a/test/python/passmanager/test_passmanager.py b/test/python/passmanager/test_passmanager.py
index b7ffdbd6029..639a959c9d4 100644
--- a/test/python/passmanager/test_passmanager.py
+++ b/test/python/passmanager/test_passmanager.py
@@ -124,3 +124,24 @@ def run(self, passmanager_ir):
         with self.assertLogContains(expected):
             out = pm.run(data)
         self.assertEqual(out, data)
+
+    def test_reruns_have_clean_property_set(self):
+        """Test that re-using a pass manager produces a clean property set for the state."""
+
+        sentinel = object()
+
+        class CheckPropertySetClean(GenericPass):
+            def __init__(self, test_case):
+                super().__init__()
+                self.test_case = test_case
+
+            def run(self, _):
+                self.test_case.assertIs(self.property_set["check_property"], None)
+                self.property_set["check_property"] = sentinel
+                self.test_case.assertIs(self.property_set["check_property"], sentinel)
+
+        pm = ToyPassManager([CheckPropertySetClean(self)])
+        pm.run(0)
+        self.assertIs(pm.property_set["check_property"], sentinel)
+        pm.run(1)
+        self.assertIs(pm.property_set["check_property"], sentinel)