From a user report:
"Thunderbird 102.0.1 is down on her knees after updating QuickFolders to 5.10.2. Either the response is very slow, or the title at the top displays "Not Responding". When I disable QF everything is back to normal."
I also experience sluggish Thunderbird UI, (even after rolling back to QuickFolders 5.10) I suspect this is related to the Folder Tree rewrite. Hiding the folder tree with [F9] gives some temporary relief.