diff --git a/.changeset/proud-items-do.md b/.changeset/proud-items-do.md
new file mode 100644
index 00000000000..e5cc17ae927
--- /dev/null
+++ b/.changeset/proud-items-do.md
@@ -0,0 +1,5 @@
+---
+'@shopify/polaris': minor
+---
+
+Added a `disabled` prop to `ResourceItem`
diff --git a/polaris-react/src/components/ResourceItem/ResourceItem.module.scss b/polaris-react/src/components/ResourceItem/ResourceItem.module.scss
index fcbaafee50e..d2eb1fb3e88 100644
--- a/polaris-react/src/components/ResourceItem/ResourceItem.module.scss
+++ b/polaris-react/src/components/ResourceItem/ResourceItem.module.scss
@@ -84,6 +84,15 @@
   margin-right: 0;
 }
 
+.disabled {
+  cursor: default;
+  color: var(--p-color-text-secondary);
+
+  &:hover {
+    background-color: transparent;
+  }
+}
+
 // Item actions
 .Actions {
   > * {
diff --git a/polaris-react/src/components/ResourceItem/ResourceItem.stories.tsx b/polaris-react/src/components/ResourceItem/ResourceItem.stories.tsx
index 8d15bc2683c..7d2b6263d60 100644
--- a/polaris-react/src/components/ResourceItem/ResourceItem.stories.tsx
+++ b/polaris-react/src/components/ResourceItem/ResourceItem.stories.tsx
@@ -301,3 +301,69 @@ export function WithVerticalAlignment() {
     </LegacyCard>
   );
 }
+
+export function WithDisabledState() {
+  const [selectedItems, setSelectedItems] = useState<
+    ResourceListProps['selectedItems']
+  >([]);
+
+  return (
+    <LegacyCard>
+      <ResourceList
+        resourceName={{singular: 'customer', plural: 'customers'}}
+        selectable
+        selectedItems={selectedItems}
+        onSelectionChange={setSelectedItems}
+        items={[
+          {
+            id: '145',
+            url: '#',
+            avatarSource:
+              'https://burst.shopifycdn.com/photos/freelance-designer-working-on-laptop.jpg?width=746',
+            name: 'Yi So-Yeon',
+            location: 'Gwangju, South Korea',
+          },
+          {
+            id: '146',
+            url: '#',
+            avatarSource:
+              'https://burst.shopifycdn.com/photos/woman-standing-in-front-of-yellow-background.jpg?width=746',
+            name: 'Jane Smith',
+            location: 'Manhattan, New York',
+          },
+          {
+            id: '147',
+            url: '#',
+            avatarSource:
+              'https://burst.shopifycdn.com/photos/relaxing-in-headphones.jpg?width=746',
+            name: 'Grace Baker',
+            location: 'Los Angeles, California',
+          },
+        ]}
+        renderItem={(item) => {
+          const {id, url, avatarSource, name, location} = item;
+
+          return (
+            <ResourceItem
+              disabled={id === '145'}
+              id={id}
+              url={url}
+              media={
+                <Avatar customer size="md" name={name} source={avatarSource} />
+              }
+              accessibilityLabel={`View details for ${name}`}
+              name={name}
+            >
+              <h3>
+                <Text fontWeight="bold" as="span">
+                  {name}
+                </Text>
+              </h3>
+              <div>{location}</div>
+            </ResourceItem>
+          );
+        }}
+      />
+    </LegacyCard>
+  );
+}
diff --git a/polaris-react/src/components/ResourceItem/ResourceItem.tsx b/polaris-react/src/components/ResourceItem/ResourceItem.tsx
index 7e9e47ee6de..e8a97112398 100644
--- a/polaris-react/src/components/ResourceItem/ResourceItem.tsx
+++ b/polaris-react/src/components/ResourceItem/ResourceItem.tsx
@@ -30,6 +30,8 @@ import styles from './ResourceItem.module.scss';
 type Alignment = 'leading' | 'trailing' | 'center' | 'fill' | 'baseline';
 
 interface BaseProps {
+  /** Whether or not interaction is disabled */
+  disabled?: boolean;
   /** Visually hidden text for screen readers used for item link */
   accessibilityLabel?: string;
   /** Individual item name used by various text labels */
@@ -159,6 +161,7 @@ class BaseResourceItem extends Component<CombinedProps, State> {
       dataHref,
       breakpoints,
       onMouseOver,
+      disabled,
     } = this.props;
 
     const {actionsMenuVisible, focused, focusedInner, selected} = this.state;
@@ -183,7 +186,7 @@ class BaseResourceItem extends Component<CombinedProps, State> {
                 label={checkboxAccessibilityLabel}
                 labelHidden
                 checked={selected}
-                disabled={loading}
+                disabled={loading || disabled}
                 bleedInlineStart="300"
                 bleedInlineEnd="300"
                 bleedBlockStart="300"
@@ -219,6 +222,7 @@ class BaseResourceItem extends Component<CombinedProps, State> {
       selectMode && styles.selectMode,
       persistActions && styles.persistActions,
       focusedInner && styles.focusedInner,
+      disabled && styles.disabled,
     );
 
     const listItemClassName = classNames(
@@ -351,7 +355,7 @@ class BaseResourceItem extends Component<CombinedProps, State> {
           <div
             ref={this.setNode}
             className={className}
-            onClick={this.handleClick}
+            onClick={disabled ? () => {} : this.handleClick}
             onFocus={this.handleFocus}
             onBlur={this.handleBlur}
             onKeyUp={this.handleKeyUp}
@@ -359,7 +363,7 @@ class BaseResourceItem extends Component<CombinedProps, State> {
             onMouseOut={this.handleMouseOut}
             data-href={url}
           >
-            {accessibleMarkup}
+            {disabled ? null : accessibleMarkup}
             {containerMarkup}
           </div>
         </div>
@@ -458,12 +462,13 @@ class BaseResourceItem extends Component<CombinedProps, State> {
   // This fires onClick when there is a URL on the item
   private handleKeyUp = (event: React.KeyboardEvent<HTMLElement>) => {
     const {
+      disabled,
       onClick = noop,
       context: {selectMode},
     } = this.props;
     const {key} = event;
 
-    if (key === 'Enter' && this.props.url && !selectMode) {
+    if (key === 'Enter' && this.props.url && !selectMode && !disabled) {
       onClick();
     }
   };
diff --git a/polaris-react/src/components/ResourceItem/tests/ResourceItem.test.tsx b/polaris-react/src/components/ResourceItem/tests/ResourceItem.test.tsx
index c04320590b4..70bc7cc05c0 100644
--- a/polaris-react/src/components/ResourceItem/tests/ResourceItem.test.tsx
+++ b/polaris-react/src/components/ResourceItem/tests/ResourceItem.test.tsx
@@ -227,6 +227,22 @@ describe('<ResourceItem />', () => {
 
       expect(element).toContainReactComponent('div', {'data-href': url} as any);
     });
+
+    it('does not render an <UnstyledLink /> when disabled prop is true', () => {
+      const element = mountWithApp(
+        <ResourceListContext.Provider value={mockDefaultContext}>
+          <ResourceItem
+            id="itemId"
+            url={url}
+            onClick={noop}
+            accessibilityLabel={ariaLabel}
+            disabled
+          />
+        </ResourceListContext.Provider>,
+      );
+
+      expect(element).not.toContainReactComponent(UnstyledLink);
+    });
   });
 
   describe('external', () => {
@@ -388,6 +404,38 @@ describe('<ResourceItem />', () => {
       expect(onClick).not.toHaveBeenCalled();
     });
 
+    it('does not call onClick when hitting keyUp on the item when onClick exists, url exists and is disabled', () => {
+      const onClick = jest.fn();
+      const wrapper = mountWithApp(
+        <ResourceListContext.Provider value={mockSelectModeContext}>
+          <ResourceItem id={itemId} url="#" onClick={onClick} disabled />
+        </ResourceListContext.Provider>,
+      );
+
+      findResourceItem(wrapper)!.trigger('onKeyUp', {key: 'Enter'});
+      expect(onClick).not.toHaveBeenCalled();
+    });
+
+    it('does not call onClick when clicking on the item when onClick exists and is disabled', () => {
+      const onClick = jest.fn();
+      const wrapper = mountWithApp(
+        <ResourceListContext.Provider value={mockDefaultContext}>
+          <ResourceItem
+            id={itemId}
+            onClick={onClick}
+            accessibilityLabel={ariaLabel}
+            disabled
+          />
+        </ResourceListContext.Provider>,
+      );
+
+      findResourceItem(wrapper)!.trigger('onClick', {
+        stopPropagation: () => {},
+        nativeEvent: {},
+      });
+      expect(onClick).not.toHaveBeenCalledWith(itemId);
+    });
+
     it('calls window.open on ctrlKey + click', () => {
       const wrapper = mountWithApp(
         <ResourceListContext.Provider value={mockDefaultContext}>
@@ -448,6 +496,15 @@ describe('<ResourceItem />', () => {
         false,
       );
     });
+
+    it('renders a disabled Checkbox if the item is disabled', () => {
+      const wrapper = mountWithApp(
+        <ResourceListContext.Provider value={mockSelectableContext}>
+          <ResourceItem id={selectedItemId} url={url} disabled />
+        </ResourceListContext.Provider>,
+      );
+      expect(wrapper).toContainReactComponent(Checkbox, {disabled: true});
+    });
   });
 
   describe('SelectMode', () => {