diff --git a/UNRELEASED.md b/UNRELEASED.md
index 8ab16cc2402..5288e93cda0 100644
--- a/UNRELEASED.md
+++ b/UNRELEASED.md
@@ -19,6 +19,7 @@ Use [the changelog guidelines](https://git.io/polaris-changelog-guidelines) to f
 - Fix bug in Safari where `Button` text is gray instead of white after changing state from disabled to enabled ([#4270](https://github.com/Shopify/polaris-react/pull/4270))
 - Bring back borders on the `IndexTable` sticky cells ([#4150](https://github.com/Shopify/polaris-react/pull/4150))
 - Adjust `IndexTable` sticky z-index to avoid collisions with focused `TextField` ([#4150](https://github.com/Shopify/polaris-react/pull/4150))
+- Adjust `IndexTable` rows to have a grey hover state when unselected ([#4359](https://github.com/Shopify/polaris-react/pull/4359))
 
 ### Documentation
 
diff --git a/src/components/IndexTable/IndexTable.scss b/src/components/IndexTable/IndexTable.scss
index cf1800a0264..5f5ccd43232 100644
--- a/src/components/IndexTable/IndexTable.scss
+++ b/src/components/IndexTable/IndexTable.scss
@@ -133,7 +133,7 @@ $loading-panel-height: rem(53px);
     &,
     .TableCell-first,
     .TableCell-first + .TableCell {
-      background-color: var(--p-surface-selected-hovered);
+      background-color: var(--p-surface-hovered);
     }
   }
 
@@ -147,6 +147,15 @@ $loading-panel-height: rem(53px);
       background-color: var(--p-surface-selected);
     }
   }
+
+  &.TableRow-hovered.TableRow-selected {
+    // stylelint-disable-next-line selector-max-class, selector-max-combinators, selector-max-specificity
+    &,
+    .TableCell-first,
+    .TableCell-first + .TableCell {
+      background-color: var(--p-surface-selected-hovered);
+    }
+  }
 }
 
 .TableRow-subdued {