diff --git a/UNRELEASED.md b/UNRELEASED.md
index 7410ce70a90..d7b2cd12b78 100644
--- a/UNRELEASED.md
+++ b/UNRELEASED.md
@@ -20,6 +20,7 @@ Use [the changelog guidelines](https://git.io/polaris-changelog-guidelines) to f
 - `Popover` now exposes an imperative `forceUpdatePosition()` API for programmatically triggering a re-render of the underlying overlay component ([#4385](https://github.com/Shopify/polaris-react/pull/4385))
 - `PositionedOverlay` now exposes an imperative `forceUpdatePosition()` API for programmatically triggering a re-render of the component ([#4385](https://github.com/Shopify/polaris-react/pull/4385))
 - Updated `IndexTable` component to hide checkboxes when `selectable` prop is `false` ([#4376](https://github.com/Shopify/polaris-react/pull/4376))
+- [Accessibility] - Removes skeleton shimmer animation on devices that have Reduced motion setting enabled [#4460](https://github.com/Shopify/polaris-react/pull/4460)
 
 ### Bug fixes
 
diff --git a/src/styles/shared/_skeleton.scss b/src/styles/shared/_skeleton.scss
index e5e5ce25691..7c375ed585d 100644
--- a/src/styles/shared/_skeleton.scss
+++ b/src/styles/shared/_skeleton.scss
@@ -23,6 +23,10 @@ $thumbnail-sizes: (
   animation: var(--polaris-animation-skeleton-shimmer)
     $skeleton-shimmer-duration linear infinite alternate;
   will-change: opacity;
+
+  @media (prefers-reduced-motion) {
+    animation: none;
+  }
 }
 
 @mixin skeleton-content {