diff --git a/.changeset/gentle-cobras-punch.md b/.changeset/gentle-cobras-punch.md
new file mode 100644
index 00000000000..af516b5a466
--- /dev/null
+++ b/.changeset/gentle-cobras-punch.md
@@ -0,0 +1,5 @@
+---
+'@shopify/polaris': patch
+---
+
+Updated the focus helper functions to no longer treat buttons with `aria-disabled="disabled"` and `tabindex="-1" (but no`disabled` attribute) as focusable.
diff --git a/polaris-react/src/utilities/focus.ts b/polaris-react/src/utilities/focus.ts
index a2cb139b824..b508619bc10 100644
--- a/polaris-react/src/utilities/focus.ts
+++ b/polaris-react/src/utilities/focus.ts
@@ -6,9 +6,9 @@ export type MouseUpBlurHandler = (
 ) => void;
 
 const FOCUSABLE_SELECTOR =
-  'a,frame,iframe,input:not([type=hidden]):not(:disabled),select:not(:disabled),textarea:not(:disabled),button:not(:disabled),*[tabindex]';
+  'a,frame,iframe,input:not([type=hidden]):not(:disabled),select:not(:disabled),textarea:not(:disabled),button:not(:disabled):not([aria-disabled]):not([tabindex="-1"]),*[tabindex]';
 const KEYBOARD_FOCUSABLE_SELECTORS =
-  'a,frame,iframe,input:not([type=hidden]):not(:disabled),select:not(:disabled),textarea:not(:disabled),button:not(:disabled),*[tabindex]:not([tabindex="-1"])';
+  'a,frame,iframe,input:not([type=hidden]):not(:disabled),select:not(:disabled),textarea:not(:disabled),button:not(:disabled):not([aria-disabled]):not([tabindex="-1"]),*[tabindex]:not([tabindex="-1"])';
 const MENUITEM_FOCUSABLE_SELECTORS =
   'a[role="menuitem"],frame[role="menuitem"],iframe[role="menuitem"],input[role="menuitem"]:not([type=hidden]):not(:disabled),select[role="menuitem"]:not(:disabled),textarea[role="menuitem"]:not(:disabled),button[role="menuitem"]:not(:disabled),*[tabindex]:not([tabindex="-1"])';
 export const handleMouseUpByBlurring: MouseUpBlurHandler = ({currentTarget}) =>