diff --git a/.changeset/smooth-starfishes-marry.md b/.changeset/smooth-starfishes-marry.md
new file mode 100644
index 00000000000..f3a9dc7dbf9
--- /dev/null
+++ b/.changeset/smooth-starfishes-marry.md
@@ -0,0 +1,5 @@
+---
+'@shopify/polaris': patch
+---
+
+Dismiss index table tooltip on mouse out
diff --git a/polaris-react/src/components/IndexTable/IndexTable.tsx b/polaris-react/src/components/IndexTable/IndexTable.tsx
index 295b9ab4bf1..3ac49db1035 100644
--- a/polaris-react/src/components/IndexTable/IndexTable.tsx
+++ b/polaris-react/src/components/IndexTable/IndexTable.tsx
@@ -914,7 +914,11 @@ function IndexTableBase({
       const tooltipContent = sortToggleLabels[index][tooltipDirection];
 
       return (
-        <Tooltip content={tooltipContent} activatorWrapper="div">
+        <Tooltip
+          content={tooltipContent}
+          activatorWrapper="div"
+          dismissOnMouseOut
+        >
           {sortMarkup}
         </Tooltip>
       );