diff --git a/.changeset/wild-mayflies-rule.md b/.changeset/wild-mayflies-rule.md
new file mode 100644
index 00000000000..7cf032a5bad
--- /dev/null
+++ b/.changeset/wild-mayflies-rule.md
@@ -0,0 +1,5 @@
+---
+'@shopify/polaris': patch
+---
+
+Added `paddingBlockStart` and `paddingBlockEnd` props to `AlphaStack`
diff --git a/polaris-react/src/components/AlphaStack/AlphaStack.scss b/polaris-react/src/components/AlphaStack/AlphaStack.scss
index 23380cc37b1..22a527ea5c2 100644
--- a/polaris-react/src/components/AlphaStack/AlphaStack.scss
+++ b/polaris-react/src/components/AlphaStack/AlphaStack.scss
@@ -18,6 +18,13 @@
   // stylelint-disable-next-line -- generated by polaris-migrator DO NOT COPY
   gap: var(--pc-stack-gap-xs);
 
+  @include responsive-props('stack', 'padding-block-end', 'padding-block-end');
+  @include responsive-props(
+    'stack',
+    'padding-block-start',
+    'padding-block-start'
+  );
+
   @media #{$p-breakpoints-sm-up} {
     // stylelint-disable-next-line -- generated by polaris-migrator DO NOT COPY
     gap: var(--pc-stack-gap-sm);
diff --git a/polaris-react/src/components/AlphaStack/AlphaStack.stories.tsx b/polaris-react/src/components/AlphaStack/AlphaStack.stories.tsx
index ceac4cd8c78..6a8afa0b5b1 100644
--- a/polaris-react/src/components/AlphaStack/AlphaStack.stories.tsx
+++ b/polaris-react/src/components/AlphaStack/AlphaStack.stories.tsx
@@ -117,3 +117,23 @@ export function WithFullWidthChildren() {
     </AlphaStack>
   );
 }
+
+export function WithResponsivePaddingBlockStartAndEnd() {
+  return (
+    <AlphaStack
+      gap="4"
+      paddingBlockStart={{sm: '2', md: '6'}}
+      paddingBlockEnd={{sm: '2', md: '6'}}
+    >
+      <Box background="surface" padding="1">
+        01
+      </Box>
+      <Box background="surface" padding="1">
+        02
+      </Box>
+      <Box background="surface" padding="1">
+        03
+      </Box>
+    </AlphaStack>
+  );
+}
diff --git a/polaris-react/src/components/AlphaStack/AlphaStack.tsx b/polaris-react/src/components/AlphaStack/AlphaStack.tsx
index 47c823eac61..c7aa39349c7 100644
--- a/polaris-react/src/components/AlphaStack/AlphaStack.tsx
+++ b/polaris-react/src/components/AlphaStack/AlphaStack.tsx
@@ -16,6 +16,8 @@ type Element = 'div' | 'ul' | 'ol' | 'fieldset';
 
 type Gap = ResponsiveProp<SpacingSpaceScale>;
 
+type Spacing = ResponsiveProp<SpacingSpaceScale>;
+
 export interface AlphaStackProps extends React.AriaAttributes {
   children?: React.ReactNode;
   /** HTML Element type
@@ -35,6 +37,18 @@ export interface AlphaStackProps extends React.AriaAttributes {
   /** Reverse the render order of child items
    * @default false
    */
+  /** Vertical start spacing around children. Accepts a spacing token or an object of spacing tokens for different screen sizes.
+   * @example
+   * paddingBlockStart='4'
+   * paddingBlockStart={{xs: '2', sm: '3', md: '4', lg: '5', xl: '6'}}
+   */
+  paddingBlockStart?: Spacing;
+  /** Vertical end spacing around children. Accepts a spacing token or an object of spacing tokens for different screen sizes.
+   * @example
+   * paddingBlockEnd='4'
+   * paddingBlockEnd={{xs: '2', sm: '3', md: '4', lg: '5', xl: '6'}}
+   */
+  paddingBlockEnd?: Spacing;
   reverseOrder?: boolean;
 }
 
@@ -45,6 +59,8 @@ export const AlphaStack = ({
   fullWidth = false,
   gap,
   id,
+  paddingBlockStart,
+  paddingBlockEnd,
   reverseOrder = false,
   ...restProps
 }: AlphaStackProps) => {
@@ -59,6 +75,18 @@ export const AlphaStack = ({
     '--pc-stack-align': align ? `${align}` : '',
     '--pc-stack-order': reverseOrder ? 'column-reverse' : 'column',
     ...getResponsiveProps('stack', 'gap', 'space', gap),
+    ...getResponsiveProps(
+      'stack',
+      'padding-block-end',
+      'space',
+      paddingBlockEnd,
+    ),
+    ...getResponsiveProps(
+      'stack',
+      'padding-block-start',
+      'space',
+      paddingBlockStart,
+    ),
   } as React.CSSProperties;
 
   return createElement(