diff --git a/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/expressions/Cast.scala b/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/expressions/Cast.scala
index 16ab3359db610..5380e6b0e8954 100644
--- a/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/expressions/Cast.scala
+++ b/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/expressions/Cast.scala
@@ -1039,13 +1039,21 @@ case class Cast(child: Expression, dataType: DataType, timeZoneId: Option[String
           }
         }
        """
-    }.mkString("\n")
+    }
+    val fieldsEvalCodes = if (ctx.INPUT_ROW != null && ctx.currentVars == null) {
+      ctx.splitExpressions(
+        expressions = fieldsEvalCode,
+        funcName = "castStruct",
+        arguments = ("InternalRow", tmpRow) :: (rowClass, result) :: Nil)
+    } else {
+      fieldsEvalCode.mkString("\n")
+    }
 
     (c, evPrim, evNull) =>
       s"""
         final $rowClass $result = new $rowClass(${fieldsCasts.length});
         final InternalRow $tmpRow = $c;
-        $fieldsEvalCode
+        $fieldsEvalCodes
         $evPrim = $result.copy();
       """
   }
diff --git a/sql/catalyst/src/test/scala/org/apache/spark/sql/catalyst/expressions/CastSuite.scala b/sql/catalyst/src/test/scala/org/apache/spark/sql/catalyst/expressions/CastSuite.scala
index a7ffa884d2286..7014994cb2600 100644
--- a/sql/catalyst/src/test/scala/org/apache/spark/sql/catalyst/expressions/CastSuite.scala
+++ b/sql/catalyst/src/test/scala/org/apache/spark/sql/catalyst/expressions/CastSuite.scala
@@ -827,4 +827,22 @@ class CastSuite extends SparkFunSuite with ExpressionEvalHelper {
 
     checkEvaluation(cast(Literal.create(input, from), to), input)
   }
+
+  test("SPARK-22500: cast for struct should not generate codes beyond 64KB") {
+    val N = 50
+
+    val fromInner = new StructType(
+      (1 to N).map(i => StructField(s"s$i", DoubleType)).toArray)
+    val toInner = new StructType(
+      (1 to N).map(i => StructField(s"i$i", IntegerType)).toArray)
+    val inputInner = Row.fromSeq((1 to N).map(i => i + 0.5))
+    val outputInner = Row.fromSeq((1 to N))
+    val fromOuter = new StructType(
+      (1 to N).map(i => StructField(s"s$i", fromInner)).toArray)
+    val toOuter = new StructType(
+      (1 to N).map(i => StructField(s"s$i", toInner)).toArray)
+    val inputOuter = Row.fromSeq((1 to N).map(_ => inputInner))
+    val outputOuter = Row.fromSeq((1 to N).map(_ => outputInner))
+    checkEvaluation(cast(Literal.create(inputOuter, fromOuter), toOuter), outputOuter)
+  }
 }