Lauren O'Donnell Research Group Atlases
Switch branches/tags
Nothing to show
Clone or download
Fetching latest commit…
Cannot retrieve the latest commit at this time.
Failed to load latest commit information.


O'Donnell Research Group (ORG) Fiber Clustering White Matter Atlases

Please cite the following papers for using the atlases:

Zhang, F., Wu, Y., Norton, I., Rathi, Y., Makris, N., O'Donnell, LJ. 
An anatomically curated fiber clustering white matter atlas for consistent white matter tract parcellation across the lifespan, 
NeuroImage, 2018.

O'Donnell LJ., Wells III WM., Golby AJ., Westin CF. 
Unbiased groupwise registration of white matter tractography, 
in: International Conference on Medical Image Computing and Computer-Assisted Intervention 2012 Oct 1 (pp. 123-130). Springer Berlin Heidelberg.

O'Donnell, LJ., and Westin, CF. 
Automatic tractography segmentation using a high-dimensional white matter atlas. 
Medical Imaging, IEEE Transactions on 26.11 (2007): 1562-1575.

For projects using Slicer and SlicerDMRI please also include the following text (or similar) and citations:


1. Download ORG-Atlases from github.

  git clone

2. Download a pre-provided atlas using the provided script '''', as follows:

  cd ORG-Atlases
  python -atlas ORG-800FC-100HCP atlas_output_folder

Note that Python 2.7.X needs to be installed before running this script.

Two atlases are available to be downloaded (-atlas), including 'ORG-800FC-100HCP' and 'ORG-2000FC-100HCP'. The first one is an anatomically curated atlas including 800 fiber clusters (see blow for a list of annotated tracts in the atlas), and the second one is an uncurated atlas including 2000 fiber clusters.

Anatomical tracts annotated in the ORG-800FC-100HCP atlas. Except for the 7 corpus callosum (CC) tracts and the middle cerebellar peduncle (MCP) tract that cross the hemispheres (C), others are hemispheric (LR). Overall, there are 58 deep white matter fiber tracts from the association, cerebellar, commissural and projection tracts, and 16 superficial tract categories according to the brain lobes.

  • Association tracts

    • arcuate fasciculus (AF) – LR
    • cingulum bundle (CB) – LR
    • external capsule (EC) – LR
    • extreme capsule (EmC) – LR
    • inferior longitudinal fasciculus (ILF) – LR
    • inferior occipito-frontal fasciculus (IoFF) – LR
    • middle longitudinal fasciculus (MdLF) – LR
    • posterior limb of internal capsule (PLIC) – LR
    • superior longitudinal fasciculus I (SLF I) – LR
    • superior longitudinal fasciculus II (SLF II) – LR
    • superior longitudinal fasciculus II (SLF III) – LR
    • uncinate fasciculus (UF) – LR
  • Cerebellar tracts

    • cortico-ponto-cerebellar (CPC) – LR
    • inferior cerebellar peduncle (ICP) – LR
    • intracerebellar input and Purkinje tract (Intra-CBLM-I&P) – LR
    • intracerebellar parallel tract (Intra-CBLM-PaT) – LR
    • middle cerebellar peduncle (MCP) – C
  • Commissural tracts

    • corpus callosum 1 (CC 1) – C
    • corpus callosum 2 (CC 2) – C
    • corpus callosum 3 (CC 3) – C
    • corpus callosum 4 (CC 4) – C
    • corpus callosum 5 (CC 5) – C
    • corpus callosum 6 (CC 6) – C
    • corpus callosum 7 (CC 7) – C
  • Projection tracts

    • corticospinal tract (CST) – LR
    • corona-radiata-frontal (CR-F) (excluding the CST) – LR
    • corona-radiata-parietal (CR-P) (excluding the CST) – LR
    • striato-frontal (SF) – LR
    • striato-occipital (SO) – LR
    • striato-parietal (SP) – LR
    • thalamo-frontal (TF) – LR
    • thalamo-occipital (TO) – LR
    • thalamo-parietal (TP) – LR
  • Superficial tracts

    • superficial-frontal (Sup-F) – LR
    • superficial-frontal-parietal (Sup-FP) – LR
    • superficial-occipital (Sup-O) – LR
    • superficial-occipital-temporal (Sup-OT) – LR
    • superficial-parietal (Sup-P) – LR
    • superficial-parietal-occipital (Sup-PO) – LR
    • superficial-parietal-temporal (Sup-PT) – LR
    • superficial-temporal (Sup-T) – LR

3. Visualize the fiber clusters and the annotated anatomical fiber tracts.

  • Load output clustered_tracts.mrml file into Slicer. This will load all clusters into the scene and display a percentage of the fibers in each cluster.
  • To view 100% of the fibers in all clusters (can be slow depending on the number of fibers clustered), load clustered_tracts_display_100_percent.mrml into Slicer. In this way, fibers from all 100 subjects are visualized in each cluster. Note that each cluster shows a common connection in the population and its variability across the 100 subjects.
  • If downloading a pre-provided anatomically curated atlas, a mrml file that defines which clusters belonging to a certain anatomical tract (e.g. T_AF.mrml) is provided. Loading the mrml file into Slicer will visualize all clusters belonging to the anatomical tract.