diff --git a/.changeset/improve-from-clause-error-messages.md b/.changeset/improve-from-clause-error-messages.md
new file mode 100644
index 000000000..ce7b5a2b1
--- /dev/null
+++ b/.changeset/improve-from-clause-error-messages.md
@@ -0,0 +1,5 @@
+---
+"@tanstack/db": patch
+---
+
+Improved error messages when invalid source types are passed to `.from()` or `.join()` methods. When users mistakenly pass a string, null, array, or other invalid type instead of an object with a collection, they now receive a clear, actionable error message with an example of the correct usage (e.g., `.from({ todos: todosCollection })`).
diff --git a/packages/db/src/errors.ts b/packages/db/src/errors.ts
index 55f9205cc..8abc79fe5 100644
--- a/packages/db/src/errors.ts
+++ b/packages/db/src/errors.ts
@@ -360,6 +360,15 @@ export class InvalidSourceError extends QueryBuilderError {
   }
 }
 
+export class InvalidSourceTypeError extends QueryBuilderError {
+  constructor(context: string, type: string) {
+    super(
+      `Invalid source for ${context}: Expected an object with a single key-value pair like { alias: collection }. ` +
+        `For example: .from({ todos: todosCollection }). Got: ${type}`
+    )
+  }
+}
+
 export class JoinConditionMustBeEqualityError extends QueryBuilderError {
   constructor() {
     super(`Join condition must be an equality expression`)
diff --git a/packages/db/src/query/builder/index.ts b/packages/db/src/query/builder/index.ts
index bd8b95178..e25cca1f4 100644
--- a/packages/db/src/query/builder/index.ts
+++ b/packages/db/src/query/builder/index.ts
@@ -10,6 +10,7 @@ import {
 } from "../ir.js"
 import {
   InvalidSourceError,
+  InvalidSourceTypeError,
   JoinConditionMustBeEqualityError,
   OnlyOneSourceAllowedError,
   QueryMustHaveFromClauseError,
@@ -60,13 +61,38 @@ export class BaseQueryBuilder<TContext extends Context = Context> {
     source: TSource,
     context: string
   ): [string, CollectionRef | QueryRef] {
-    if (Object.keys(source).length !== 1) {
+    // Validate source is a plain object (not null, array, string, etc.)
+    // We use try-catch to handle null/undefined gracefully
+    let keys: Array<string>
+    try {
+      keys = Object.keys(source)
+    } catch {
+      // eslint-disable-next-line @typescript-eslint/no-unnecessary-condition
+      const type = source === null ? `null` : `undefined`
+      throw new InvalidSourceTypeError(context, type)
+    }
+
+    // Check if it's an array (arrays pass Object.keys but aren't valid sources)
+    if (Array.isArray(source)) {
+      throw new InvalidSourceTypeError(context, `array`)
+    }
+
+    // Validate exactly one key
+    if (keys.length !== 1) {
+      if (keys.length === 0) {
+        throw new InvalidSourceTypeError(context, `empty object`)
+      }
+      // Check if it looks like a string was passed (has numeric keys)
+      if (keys.every((k) => !isNaN(Number(k)))) {
+        throw new InvalidSourceTypeError(context, `string`)
+      }
       throw new OnlyOneSourceAllowedError(context)
     }
 
-    const alias = Object.keys(source)[0]!
+    const alias = keys[0]!
     const sourceValue = source[alias]
 
+    // Validate the value is a Collection or QueryBuilder
     let ref: CollectionRef | QueryRef
 
     if (sourceValue instanceof CollectionImpl) {
diff --git a/packages/db/tests/query/builder/from.test.ts b/packages/db/tests/query/builder/from.test.ts
index 62946b094..6e4ec2f64 100644
--- a/packages/db/tests/query/builder/from.test.ts
+++ b/packages/db/tests/query/builder/from.test.ts
@@ -3,6 +3,7 @@ import { CollectionImpl } from "../../../src/collection/index.js"
 import { Query, getQueryIR } from "../../../src/query/builder/index.js"
 import { eq } from "../../../src/query/builder/functions.js"
 import {
+  InvalidSourceTypeError,
   OnlyOneSourceAllowedError,
   QueryMustHaveFromClauseError,
 } from "../../../src/errors"
@@ -108,4 +109,60 @@ describe(`QueryBuilder.from`, () => {
       } as any)
     }).toThrow(OnlyOneSourceAllowedError)
   })
+
+  it(`throws helpful error when passing a string instead of an object`, () => {
+    const builder = new Query()
+
+    expect(() => {
+      builder.from(`employees` as any)
+    }).toThrow(InvalidSourceTypeError)
+
+    expect(() => {
+      builder.from(`employees` as any)
+    }).toThrow(
+      /Invalid source for from clause: Expected an object with a single key-value pair/
+    )
+  })
+
+  it(`throws helpful error when passing null`, () => {
+    const builder = new Query()
+
+    expect(() => {
+      builder.from(null as any)
+    }).toThrow(InvalidSourceTypeError)
+
+    expect(() => {
+      builder.from(null as any)
+    }).toThrow(
+      /Invalid source for from clause: Expected an object with a single key-value pair/
+    )
+  })
+
+  it(`throws helpful error when passing an array`, () => {
+    const builder = new Query()
+
+    expect(() => {
+      builder.from([employeesCollection] as any)
+    }).toThrow(InvalidSourceTypeError)
+
+    expect(() => {
+      builder.from([employeesCollection] as any)
+    }).toThrow(
+      /Invalid source for from clause: Expected an object with a single key-value pair/
+    )
+  })
+
+  it(`throws helpful error when passing undefined`, () => {
+    const builder = new Query()
+
+    expect(() => {
+      builder.from(undefined as any)
+    }).toThrow(InvalidSourceTypeError)
+
+    expect(() => {
+      builder.from(undefined as any)
+    }).toThrow(
+      /Invalid source for from clause: Expected an object with a single key-value pair/
+    )
+  })
 })