diff --git a/packages/main/cypress/specs/MultiComboBox.cy.tsx b/packages/main/cypress/specs/MultiComboBox.cy.tsx
index 2e704bf87590..6dacca7e109e 100644
--- a/packages/main/cypress/specs/MultiComboBox.cy.tsx
+++ b/packages/main/cypress/specs/MultiComboBox.cy.tsx
@@ -3430,6 +3430,54 @@ describe("Keyboard Handling", () => {
 			.should("have.value", "I");
 	});
 
+	it("should deselect all tokens on [Escape] key when focus is on tokenizer", () => {
+		cy.mount(
+			<MultiComboBox>
+				<MultiComboBoxItem selected={true} text="Andora"></MultiComboBoxItem>
+				<MultiComboBoxItem selected={true} text="Bulgaria"></MultiComboBoxItem>
+				<MultiComboBoxItem selected={true} text="Canada"></MultiComboBoxItem>
+			</MultiComboBox>
+		);
+
+		cy.get("[ui5-multi-combobox]")
+			.shadow()
+			.find("[ui5-tokenizer]")
+			.find("[ui5-token]")
+			.should("have.length", 3);
+
+		cy.get("[ui5-multi-combobox]")
+			.realClick();
+
+		cy.realPress("Backspace");
+
+		cy.get("[ui5-multi-combobox]")
+			.shadow()
+			.find("[ui5-tokenizer]")
+			.find("[ui5-token]")
+			.last()
+			.should("be.focused");
+
+		cy.realPress(["Shift", "Home"]);
+
+		cy.get("[ui5-multi-combobox]")
+			.shadow()
+			.find("[ui5-tokenizer]")
+			.find("[ui5-token]")
+			.each($token => {
+				cy.wrap($token).should("have.attr", "selected");
+			});
+
+		cy.realPress("Escape");
+
+		cy.get("[ui5-multi-combobox]")
+			.shadow()
+			.find("[ui5-tokenizer]")
+			.find("[ui5-token]")
+			.each($token => {
+				cy.wrap($token).should("not.have.attr", "selected");
+			});
+	});
+
 	it("Selects an item when enter is pressed and value matches a text of an item in the list", () => {
 		cy.mount(
 			<>
diff --git a/packages/main/cypress/specs/MultiInput.cy.tsx b/packages/main/cypress/specs/MultiInput.cy.tsx
index 7734b4d81319..6dc87533e408 100644
--- a/packages/main/cypress/specs/MultiInput.cy.tsx
+++ b/packages/main/cypress/specs/MultiInput.cy.tsx
@@ -1502,6 +1502,39 @@ describe("Keyboard handling", () => {
 		cy.get("@changeSpy")
 			.should("have.been.calledOnce");
 	});
+
+	it("should deselect all tokens on [Escape] key", () => {
+		cy.mount(
+			<MultiInput>
+				<Token slot="tokens" text="Andora"></Token>
+				<Token slot="tokens" text="Bulgaria"></Token>
+				<Token slot="tokens" text="Canada"></Token>
+			</MultiInput>
+		);
+
+		cy.get("[ui5-multi-input]")
+			.shadow()
+			.find("input")
+			.realClick();
+
+		cy.realPress("Home");
+
+		cy.get("[ui5-token]")
+			.eq(0)
+			.should("be.focused");
+
+		cy.realPress(["Shift", "End"]);
+
+		cy.get("[ui5-token]").each($token => {
+			cy.wrap($token).should("have.attr", "selected");
+		});
+
+		cy.realPress("Escape");
+
+		cy.get("[ui5-token]").each($token => {
+			cy.wrap($token).should("not.have.attr", "selected");
+		});
+	});
 });
 
 describe("MultiInput Composition", () => {
diff --git a/packages/main/cypress/specs/Tokenizer.cy.tsx b/packages/main/cypress/specs/Tokenizer.cy.tsx
index 0dd97b5ce12a..c8495e8af866 100755
--- a/packages/main/cypress/specs/Tokenizer.cy.tsx
+++ b/packages/main/cypress/specs/Tokenizer.cy.tsx
@@ -1590,6 +1590,104 @@ describe("Keyboard Handling", () => {
 			.eq(1)
 			.should("have.attr", "selected");
 	});
+
+	it("should deselect all tokens on [Escape] key", () => {
+		cy.get("[ui5-token]")
+			.eq(0)
+			.as("firstToken");
+
+		cy.get("[ui5-token]")
+			.eq(1)
+			.as("secondToken");
+
+		cy.get("[ui5-token]")
+			.eq(2)
+			.as("thirdToken");
+
+		cy.get("@firstToken")
+			.realClick();
+
+		cy.realPress(["Shift", "End"]);
+
+		cy.get("@firstToken")
+			.should("have.attr", "selected");
+
+		cy.get("@secondToken")
+			.should("have.attr", "selected");
+
+		cy.get("@thirdToken")
+			.should("have.attr", "selected");
+
+		cy.realPress("Escape");
+
+		cy.get("@firstToken")
+			.should("not.have.attr", "selected");
+
+		cy.get("@secondToken")
+			.should("not.have.attr", "selected");
+
+		cy.get("@thirdToken")
+			.should("not.have.attr", "selected");
+	});
+
+	it("should fire selection-change event on [Escape] when tokens are selected", () => {
+		cy.mount(
+			<Tokenizer onSelectionChange={cy.stub().as("selectionChange")}>
+				<Token text="Andora"></Token>
+				<Token text="Bulgaria"></Token>
+				<Token text="Canada"></Token>
+			</Tokenizer>
+		);
+
+		cy.get("[ui5-token]")
+			.eq(0)
+			.realClick();
+
+		cy.get("@selectionChange")
+			.should("have.been.called");
+
+		cy.get("@selectionChange")
+			.invoke("resetHistory");
+
+		cy.realPress("Escape");
+
+		cy.get("@selectionChange")
+			.should("have.been.calledOnce");
+
+		cy.get("@selectionChange")
+			.its("firstCall.args.0.detail.tokens")
+			.should("have.length", 0);
+	});
+
+	it("should not fire selection-change on [Escape] when no tokens are selected", () => {
+		cy.mount(
+			<Tokenizer onSelectionChange={cy.stub().as("selectionChange")}>
+				<Token text="Andora"></Token>
+				<Token text="Bulgaria"></Token>
+			</Tokenizer>
+		);
+
+		cy.get("[ui5-token]")
+			.eq(0)
+			.realClick();
+
+		cy.get("@selectionChange")
+			.invoke("resetHistory");
+
+		cy.realPress("Space");
+
+		cy.get("[ui5-token]")
+			.eq(0)
+			.should("not.have.attr", "selected");
+
+		cy.get("@selectionChange")
+			.invoke("resetHistory");
+
+		cy.realPress("Escape");
+
+		cy.get("@selectionChange")
+			.should("not.have.been.called");
+	});
 });
 
 describe("Clipboard Operations", () => {
diff --git a/packages/main/src/Tokenizer.ts b/packages/main/src/Tokenizer.ts
index 0cdd39e560a1..6a4f96c00f1e 100644
--- a/packages/main/src/Tokenizer.ts
+++ b/packages/main/src/Tokenizer.ts
@@ -716,6 +716,10 @@ class Tokenizer extends UI5Element implements IFormInputElement {
 	_onkeydown(e: KeyboardEvent) {
 		const isCtrl = !!(e.metaKey || e.ctrlKey);
 
+		if (isEscape(e)) {
+			return this._deselectAllTokens();
+		}
+
 		if ((isCtrl && ["c", "x"].includes(e.key.toLowerCase())) || isDeleteShift(e) || isInsertCtrl(e)) {
 			e.preventDefault();
 
@@ -1070,6 +1074,17 @@ class Tokenizer extends UI5Element implements IFormInputElement {
 		}
 	}
 
+	_deselectAllTokens() {
+		const hadSelection = this._selectedTokens.length > 0;
+		this._tokens.forEach(token => { token.selected = false; });
+
+		if (hadSelection) {
+			this.fireDecoratorEvent("selection-change", {
+				tokens: [],
+			});
+		}
+	}
+
 	get hasTokens() {
 		return this._tokens.length > 0;
 	}