diff --git a/.github/workflows/codeql-analysis.yml b/.github/workflows/codeql-analysis.yml
index 998bf6a50e2a..7a320622d76a 100644
--- a/.github/workflows/codeql-analysis.yml
+++ b/.github/workflows/codeql-analysis.yml
@@ -35,10 +35,9 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: '3.11'
-        cache: pip
     - name: Used versions
       run: ./ci/print-versions
-    - name: Install pip dependencies
+    - name: Install Python dependencies
       run: ./ci/pip-install
 
     - name: Initialize CodeQL
diff --git a/.github/workflows/docs.yml b/.github/workflows/docs.yml
index e68cc55ad36f..06d3e6b32322 100644
--- a/.github/workflows/docs.yml
+++ b/.github/workflows/docs.yml
@@ -26,14 +26,14 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: '3.11'
-        cache: pip
-        cache-dependency-path: docs/requirements.txt
     - name: Install apt dependencies
       run: |
         sudo apt update
         sudo apt install -y graphviz
-    - name: Install pip dependencies
-      run: pip install -r docs/requirements.txt
+    - name: Install Python dependencies
+      run: |
+        pip install uv
+        uv pip install --system -r docs/requirements.txt
     - name: Sphinx build
       run: |
         echo "::add-matcher::.github/matchers/sphinx.json"
@@ -54,10 +54,11 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: '3.11'
-        cache: pip
         cache-dependency-path: docs/requirements.txt
-    - name: Install pip dependencies
-      run: pip install -r docs/requirements.txt
+    - name: Install Python dependencies
+      run: |
+        pip install uv
+        uv pip install --system -r docs/requirements.txt
     - name: Sphinx linkcheck
       run: |
         ./ci/run-docs linkcheck
diff --git a/.github/workflows/licenses-update.yml b/.github/workflows/licenses-update.yml
index d0f5d2591078..c262d4add039 100644
--- a/.github/workflows/licenses-update.yml
+++ b/.github/workflows/licenses-update.yml
@@ -28,9 +28,7 @@ jobs:
         submodules: true
     - uses: actions/cache@v4
       with:
-        path: |
-          ~/.cache/pip
-          ~/.cache/pre-commit
+        path: ~/.cache/pre-commit
         key: ${{ runner.os }}-pre-commit-${{ hashFiles('pyproject.toml') }}-${{ hashFiles('.pre-commit-config.yaml') }}
     - name: Set up Python
       uses: actions/setup-python@v5
@@ -38,9 +36,8 @@ jobs:
         python-version: '3.11'
     - name: Install dependencies
       run: |
-        python -m pip install $(sed -n 's/.*"\(pip==\([^"]*\)\)".*/\1/p' pyproject.toml)
-        pip install $(sed -n 's/.*"\(wheel==\([^"]*\)\)".*/\1/p' pyproject.toml)
-        pip install $(sed -n 's/.*"\(pre-commit==\([^"]*\)\)".*/\1/p' pyproject.toml)
+        python -m pip install $(sed -n 's/.*"\(uv==\([^"]*\)\)".*/\1/p' pyproject.toml)
+        uv pip install --system $(sed -n 's/.*"\(pre-commit==\([^"]*\)\)".*/\1/p' pyproject.toml)
     - run: ./scripts/generate-license-data
     - name: Update renovate branch
       if: github.ref != 'refs/heads/main'
diff --git a/.github/workflows/migrations.yml b/.github/workflows/migrations.yml
index 8c8142a44c40..45ae705f02a1 100644
--- a/.github/workflows/migrations.yml
+++ b/.github/workflows/migrations.yml
@@ -44,8 +44,7 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: 3.11
-        cache: pip
-    - name: Install pip dependencies
+    - name: Install Python dependencies
       run: ./ci/pip-install migrations
     - name: Check missing migrations
       run: ./ci/run-checkmigrate
diff --git a/.github/workflows/mypy.yml b/.github/workflows/mypy.yml
index c1c7bc02593d..88df80ed32a5 100644
--- a/.github/workflows/mypy.yml
+++ b/.github/workflows/mypy.yml
@@ -27,7 +27,6 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: '3.11'
-        cache: pip
     - name: Install dependencies
       run: ./ci/pip-install mypy
 
diff --git a/.github/workflows/pre-commit.yml b/.github/workflows/pre-commit.yml
index 722e6d53572f..b3061192f2c2 100644
--- a/.github/workflows/pre-commit.yml
+++ b/.github/workflows/pre-commit.yml
@@ -24,22 +24,20 @@ jobs:
     - uses: actions/checkout@v4
     - uses: actions/cache@v4
       with:
-        path: |
-          ~/.cache/pip
-          ~/.cache/pre-commit
-        key: ${{ runner.os }}-pre-commit-${{ hashFiles('**/requirements*.txt') }}-${{ hashFiles('.pre-commit-config.yaml') }}-${{ hashFiles('pyproject.toml') }}
+        path: ~/.cache/pre-commit
+        key: ${{ runner.os }}-pre-commit-${{ hashFiles('.pre-commit-config.yaml') }}
     - name: Setup Python
       uses: actions/setup-python@v5
       with:
         python-version: '3.11'
-    - name: Update pip
-      run: python -m pip install --upgrade pip wheel
+    - name: Install uv
+      run: curl -LsSf https://astral.sh/uv/install.sh | sh
     - name: Install dependencies
       run: |
         if [ -f requirements-lint.txt ] ; then
-          pip install -r requirements-lint.txt
+          uv pip install --system -r requirements-lint.txt
         else
-          pip install $(sed -n 's/.*"\(pre-commit==\([^"]*\)\)".*/\1/p' pyproject.toml)
+          uv pip install --system $(sed -n 's/.*"\(pre-commit==\([^"]*\)\)".*/\1/p' pyproject.toml)
         fi
     - name: pre-commit
       run: pre-commit run --all
diff --git a/.github/workflows/pylint.yml b/.github/workflows/pylint.yml
index 3b6b03ea9b40..7779f80775b9 100644
--- a/.github/workflows/pylint.yml
+++ b/.github/workflows/pylint.yml
@@ -25,12 +25,10 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: '3.11'
-        cache: pip
     - name: Install dependencies
       run: |
-        python -m pip install $(sed -n 's/.*"\(pip==\([^"]*\)\)".*/\1/p' pyproject.toml)
-        pip install $(sed -n 's/.*"\(wheel==\([^"]*\)\)".*/\1/p' pyproject.toml)
-        pip install $(sed -n 's/.*"\(pylint==\([^"]*\)\)".*/\1/p' pyproject.toml)
+        python -m pip install $(sed -n 's/.*"\(uv==\([^"]*\)\)".*/\1/p' pyproject.toml)
+        uv pip install --system $(sed -n 's/.*"\(pylint==\([^"]*\)\)".*/\1/p' pyproject.toml)
     - name: Add pylint annotator
       uses: pr-annotators/pylint-pr-annotator@v0.0.1
 
diff --git a/.github/workflows/schema-update.yml b/.github/workflows/schema-update.yml
index db1ee6610b54..2bd5d23cdf07 100644
--- a/.github/workflows/schema-update.yml
+++ b/.github/workflows/schema-update.yml
@@ -28,12 +28,11 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: '3.11'
-    - name: Install pip dependencies
+    - name: Install Python dependencies
       run: |
-        python -m pip install $(sed -n 's/.*"\(pip==\([^"]*\)\)".*/\1/p' pyproject.toml)
-        pip install $(sed -n 's/.*"\(wheel==\([^"]*\)\)".*/\1/p' pyproject.toml)
-        pip install $(sed -n 's/.*"\(weblate-schemas==\([^"]*\)\)".*/\1/p' pyproject.toml)
-        pip install $(sed -n 's/.*"\(pre-commit==\([^"]*\)\)".*/\1/p' pyproject.toml)
+        python -m pip install $(sed -n 's/.*"\(uv==\([^"]*\)\)".*/\1/p' pyproject.toml)
+        uv pip install --system $(sed -n 's/.*"\(weblate-schemas==\([^"]*\)\)".*/\1/p' pyproject.toml)
+        uv pip install --system $(sed -n 's/.*"\(pre-commit==\([^"]*\)\)".*/\1/p' pyproject.toml)
     - run: make -C docs update-schemas
     - run: pre-commit run --files $(git diff --name-only)
       continue-on-error: true
diff --git a/.github/workflows/setup.yml b/.github/workflows/setup.yml
index a5c857dad6b1..d0ddb9462f7c 100644
--- a/.github/workflows/setup.yml
+++ b/.github/workflows/setup.yml
@@ -33,11 +33,12 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: '3.11'
-        cache: pip
     - name: Used versions
       run: ./ci/print-versions
-    - name: Install pip dependencies
+    - name: Install Python dependencies
       run: ./ci/pip-install
+    - name: Install setuptools
+      run: uv pip install --system $(sed -n 's/.*"\(setuptools[<>=]=\([^"]*\)\)".*/\1/p' pyproject.toml)
     - name: Install Weblate
       run: coverage run ./setup.py install
     - name: Check difference
@@ -67,13 +68,12 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: '3.11'
-        cache: pip
     - name: Used versions
       run: ./ci/print-versions
-    - name: Install pip dependencies
+    - name: Install Python dependencies
       run: ./ci/pip-install
     - name: Install Weblate
-      run: pip install '.[all]'
+      run: uv pip install --system '.[all]'
     - name: Check difference
       run: diff -ruNqp weblate $(python -c 'import weblate; import os; print(os.path.dirname(weblate.__file__))')
 
@@ -92,13 +92,11 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: '3.11'
-        cache: pip
-    - name: Install pip dependencies
+    - name: Install Python dependencies
       run: |
-        python -m pip install $(sed -n 's/.*"\(pip==\([^"]*\)\)".*/\1/p' pyproject.toml)
-        pip install $(sed -n 's/.*"\(wheel==\([^"]*\)\)".*/\1/p' pyproject.toml)
-        pip install $(sed -n 's/.*"\(twine==\([^"]*\)\)".*/\1/p' pyproject.toml)
-        pip install $(sed -n 's/.*"\(build==\([^"]*\)\)".*/\1/p' pyproject.toml)
+        python -m pip install $(sed -n 's/.*"\(uv==\([^"]*\)\)".*/\1/p' pyproject.toml)
+        uv pip install --system $(sed -n 's/.*"\(twine==\([^"]*\)\)".*/\1/p' pyproject.toml)
+        uv pip install --system $(sed -n 's/.*"\(build==\([^"]*\)\)".*/\1/p' pyproject.toml)
     - name: build
       run: python -m build
     - name: Twine check
@@ -122,14 +120,14 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: '3.11'
-        cache: pip
-        cache-dependency-path: docs/requirements.txt
     - name: Install apt dependencies
       run: |
         sudo apt update
         sudo apt install -y graphviz pandoc
-    - name: Install pip dependencies
-      run: pip install -r docs/requirements.txt
+    - name: Install Python dependencies
+      run: |
+        python -m pip install $(sed -n 's/.*"\(uv==\([^"]*\)\)".*/\1/p' pyproject.toml)
+        uv pip install --system -r docs/requirements.txt
     - name: Sphinx build
       run: ./ci/run-docs
     - name: Convert release notes
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 5ecc05435a53..87fc4073cd68 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -68,10 +68,9 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: ${{ matrix.python-version }}
-        cache: pip
     - name: Used versions
       run: ./ci/print-versions
-    - name: Install pip dependencies
+    - name: Install Python dependencies
       run: ./ci/pip-install ${{ matrix.requirements }}
     - name: Prepare database
       run: ./ci/prepare-database
diff --git a/ci/pip-install b/ci/pip-install
index b089b7269a29..17e4760a4503 100755
--- a/ci/pip-install
+++ b/ci/pip-install
@@ -8,16 +8,14 @@ set -e -x
 
 # Install CI requirements
 # shellcheck disable=SC2046
-python -m pip install $(sed -n 's/.*"\(pip==\([^"]*\)\)".*/\1/p' pyproject.toml)
-# shellcheck disable=SC2046
-pip install $(sed -n 's/.*"\(wheel==\([^"]*\)\)".*/\1/p' pyproject.toml)
+python -m pip install $(sed -n 's/.*"\(uv==\([^"]*\)\)".*/\1/p' pyproject.toml)
 
 # Workaround for
 # SystemError: ffi_prep_closure(): bad user_data (it seems that the version of the libffi library seen at runtime is different from the 'ffi.h' file seen at compile-time)
-pip install --no-binary :all: cffi
+uv pip install --system --no-binary :all: cffi
 
 if [ "${1:-latest}" = migrations ] ; then
-    pip install -e ".[all,mysql,ci]"
+    uv pip install --system -e ".[all,mysql,ci]"
 else
     if [ "${1:-latest}" = minimal ] ; then
         # Adjust deps to force minimal version
@@ -25,19 +23,19 @@ else
     fi
 
     if [ "${1:-latest}" = mypy ] ; then
-      pip install -e ".[all,mysql,ci,mypy,test]"
+      uv pip install --system -e ".[all,mysql,ci,mypy,test]"
     else
-      pip install -e ".[all,mysql,ci,test]"
+      uv pip install --system -e ".[all,mysql,ci,test]"
     fi
     if [ "${1:-latest}" = edge ] ; then
-        pip install --no-binary=lxml --upgrade-strategy eager -U -e ".[all,mysql,test,ci]"
+        uv pip install --system --no-binary=lxml --upgrade -e ".[all,mysql,test,ci]"
         # Install from git / pre-release
-        pip install --no-deps --upgrade --force-reinstall https://github.com/translate/translate/archive/master.zip
-        pip install --no-deps --upgrade --force-reinstall https://github.com/WeblateOrg/language-data/archive/main.zip
-        pip install --no-deps --upgrade --force-reinstall https://github.com/WeblateOrg/translation-finder/archive/main.zip
-        pip install --upgrade --pre Django
+        uv pip install --system --no-deps --upgrade --force-reinstall https://github.com/translate/translate/archive/master.zip
+        uv pip install --system --no-deps --upgrade --force-reinstall https://github.com/WeblateOrg/language-data/archive/main.zip
+        uv pip install --system --no-deps --upgrade --force-reinstall https://github.com/WeblateOrg/translation-finder/archive/main.zip
+        uv pip install --system --upgrade --pre Django
     fi
 fi
 
 # Verify that deps are consistent
-pip check
+uv pip check
diff --git a/ci/run-migrate b/ci/run-migrate
index cf4f4b9ba21a..93a2792e01b4 100755
--- a/ci/run-migrate
+++ b/ci/run-migrate
@@ -27,14 +27,14 @@ fi
 check
 git checkout "$TAG"
 check
-# Use clean virtualenv for each version, this avoids pip problems when trying to downgrade from current versions
-virtualenv --python python3.11 ".venv-$TAG"
+# Use clean virtualenv for each version, this avoids problems when trying to downgrade from current versions
+uv venv --python python3.11 ".venv-$TAG"
 check
 # shellcheck source=/dev/null
 . ".venv-$TAG/bin/activate"
 # Workaround for SystemError: ffi_prep_closure(): bad user_data
-pip install --no-binary :all: cffi
-pip install -e ".[all,mysql]"
+uv pip install --no-binary :all: cffi
+uv pip install -e ".[all,mysql]"
 check
 echo "DATABASES['default']['HOST'] = '$CI_DB_HOST'" >> weblate/settings_test.py
 check
diff --git a/pyproject.toml b/pyproject.toml
index 99e93061d064..3117f0cdc2c0 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -113,11 +113,8 @@ antispam = [
 ci = [
   "build==1.2.1",
   "coverage==7.5.1",
-  "pip==24.0",
-  "setuptools==69.5.1",
-  "twine==5.1.0",
-  "virtualenv==20.26.2",
-  "wheel==0.43.0"
+  "uv==0.1.45",
+  "twine==5.1.0"
 ]
 dev = [
   "Weblate[all,ci,test,lint,mypy]",