diff --git a/core/tools/blueos_startup_update/blueos_startup_update b/core/tools/blueos_startup_update/blueos_startup_update
index 49da553dc..b7a37d967 100755
--- a/core/tools/blueos_startup_update/blueos_startup_update
+++ b/core/tools/blueos_startup_update/blueos_startup_update
@@ -404,6 +404,43 @@ def ensure_user_data_structure_is_in_place() -> bool:
 
     # This patch doesn't require restart to take effect
     return False
+  
+def load_pi5_overlays_in_runtime() -> bool:
+    is_pi5 = False
+    with open('/proc/cpuinfo', 'r') as f:
+        if 'Raspberry Pi 5' in f.read():
+            is_pi5 = True
+    if not is_pi5:
+        return False
+    commands = [
+        # serial ports, checked individually
+        "dtoverlay uart0-pi5", # serial1, /dev/ttyAMA0
+        "dtoverlay uart3-pi5", # serial4, /dev/ttyAMA3
+        "dtoverlay uart4-pi5", # serial5, /dev/ttyAMA4
+        "dtoverlay uart2-pi5", # serial3, /dev/ttyAMA2
+
+        # i2c-6: bar30 and friends
+        "dtoverlay i2c-gpio i2c_gpio_sda=22 i2c_gpio_scl=23 bus=6 i2c_gpio_delay_us=0",
+
+        # i2c1: ADS1115, AK09915, BME280
+        "dtoverlay i2c1-pi5 baudrate=400000",
+
+        # i2c3: PCA
+        "dtoverlay i2c3-pi5 baudrate=400000",
+
+        # SPI1: MMC5983
+        "dtoverlay spi1-3cs",
+
+        # SPI0: LED
+        "dtoverlay spi0-led",
+
+        #symlink for i2c4
+        "ln -s /dev/i2c-3 /dev/i2c-4"
+    ]
+    for command in commands:
+        logger.info(run_command(f"sudo {command}", False))
+    return False
+
 
 def run_command_is_working():
     output = run_command("uname -a", check=False)
@@ -434,6 +471,7 @@ def main() -> int:
         ensure_user_data_structure_is_in_place,
         ensure_nginx_permissions,
         #create_dns_conf_host_link,
+        load_pi5_overlays_in_runtime,
     ]
 
     logger.info("The following patches will be applied if needed:", [patch_to_apply.__name__ for patch_to_apply in patches_to_apply])