diff --git a/src/wp-includes/option.php b/src/wp-includes/option.php
index 66b22e9fc498..344dfee088cb 100644
--- a/src/wp-includes/option.php
+++ b/src/wp-includes/option.php
@@ -1330,7 +1330,8 @@ function get_transient( $transient ) {
 
 			if ( ! isset( $alloptions[ $transient_option ] ) ) {
 				$transient_timeout = '_transient_timeout_' . $transient;
-				$timeout           = get_option( $transient_timeout );
+				wp_prime_option_caches( array( $transient_option, $transient_timeout ) );
+				$timeout = get_option( $transient_timeout );
 				if ( false !== $timeout && $timeout < time() ) {
 					delete_option( $transient_option );
 					delete_option( $transient_timeout );
@@ -1410,6 +1411,7 @@ function set_transient( $transient, $value, $expiration = 0 ) {
 	} else {
 		$transient_timeout = '_transient_timeout_' . $transient;
 		$transient_option  = '_transient_' . $transient;
+		wp_prime_option_caches( array( $transient_option, $transient_timeout ) );
 
 		if ( false === get_option( $transient_option ) ) {
 			$autoload = 'on';
diff --git a/tests/phpunit/tests/option/transient.php b/tests/phpunit/tests/option/transient.php
index 6c6ba4e2da4b..d4f6c6ce43ae 100644
--- a/tests/phpunit/tests/option/transient.php
+++ b/tests/phpunit/tests/option/transient.php
@@ -80,6 +80,87 @@ public function test_transient_data_with_timeout() {
 		$this->assertFalse( get_transient( $key ) );
 	}
 
+	/**
+	 * Ensure get_transient() makes a single database request.
+	 *
+	 * @ticket 61193
+	 *
+	 * @covers ::get_transient
+	 */
+	public function test_get_transient_with_timeout_makes_a_single_database_call() {
+		global $wpdb;
+		$key                        = 'test_transient';
+		$value                      = 'test_value';
+		$timeout                    = 100;
+		$expected_query             = "SELECT option_name, option_value FROM $wpdb->options WHERE option_name IN ('_transient_{$key}','_transient_timeout_{$key}')";
+		$unexpected_query_transient = "SELECT option_value FROM $wpdb->options WHERE option_name = '_transient_{$key}' LIMIT 1";
+		$unexpected_query_timeout   = "SELECT option_value FROM $wpdb->options WHERE option_name = '_transient_timeout_{$key}' LIMIT 1";
+		$queries                    = array();
+
+		set_transient( $key, $value, $timeout );
+
+		// Clear the cache of both the transient and the timeout.
+		$option_names = array(
+			'_transient_' . $key,
+			'_transient_timeout_' . $key,
+		);
+		foreach ( $option_names as $option_name ) {
+			wp_cache_delete( $option_name, 'options' );
+		}
+
+		add_filter(
+			'query',
+			function ( $query ) use ( &$queries ) {
+				$queries[] = $query;
+				return $query;
+			}
+		);
+
+		$before_queries = get_num_queries();
+		$this->assertSame( $value, get_transient( $key ) );
+		$transient_queries = get_num_queries() - $before_queries;
+		$this->assertSame( 1, $transient_queries, 'Expected a single database query to retrieve the transient.' );
+		$this->assertContains( $expected_query, $queries, 'Expected query to prime both transient options in a single call.' );
+		// Note: Some versions of PHPUnit and/or the test suite may report failures as asserting to contain rather than not to contain.
+		$this->assertNotContains( $unexpected_query_transient, $queries, 'Unexpected query of transient option individually.' );
+		$this->assertNotContains( $unexpected_query_timeout, $queries, 'Unexpected query of transient timeout option individually.' );
+	}
+
+	/**
+	 * Ensure set_transient() primes the option cache checking for an existing transient.
+	 *
+	 * @ticket 61193
+	 *
+	 * @covers ::set_transient
+	 */
+	public function test_set_transient_primes_option_cache() {
+		global $wpdb;
+		$key                        = 'test_transient';
+		$value                      = 'test_value';
+		$timeout                    = 100;
+		$expected_query             = "SELECT option_name, option_value FROM $wpdb->options WHERE option_name IN ('_transient_{$key}','_transient_timeout_{$key}')";
+		$unexpected_query_transient = "SELECT option_value FROM $wpdb->options WHERE option_name = '_transient_{$key}' LIMIT 1";
+		$unexpected_query_timeout   = "SELECT option_value FROM $wpdb->options WHERE option_name = '_transient_timeout_{$key}' LIMIT 1";
+		$queries                    = array();
+
+		add_filter(
+			'query',
+			function ( $query ) use ( &$queries ) {
+				$queries[] = $query;
+				return $query;
+			}
+		);
+
+		$before_queries = get_num_queries();
+		$this->assertTrue( set_transient( $key, $value, $timeout ) );
+		$transient_queries = get_num_queries() - $before_queries;
+		$this->assertSame( 3, $transient_queries, 'Expected three database queries setting the transient.' );
+		$this->assertContains( $expected_query, $queries, 'Expected query to prime both transient options in a single call.' );
+		// Note: Some versions of PHPUnit and/or the test suite may report failures as asserting to contain rather than not to contain.
+		$this->assertNotContains( $unexpected_query_transient, $queries, 'Unexpected query of transient option individually.' );
+		$this->assertNotContains( $unexpected_query_timeout, $queries, 'Unexpected query of transient timeout option individually.' );
+	}
+
 	/**
 	 * @ticket 22807
 	 *