diff --git a/src/wp-admin/includes/post.php b/src/wp-admin/includes/post.php
index ebdd61df345dc..3ee280ca33184 100644
--- a/src/wp-admin/includes/post.php
+++ b/src/wp-admin/includes/post.php
@@ -762,9 +762,10 @@ function get_default_post_to_edit( $post_type = 'post', $create_in_db = false )
 	}
 
 	if ( $create_in_db ) {
+		$default_title = post_type_supports( $post_type, 'title' ) ? __( 'Auto Draft' ) : __( '(no title supported)' );
 		$post_id = wp_insert_post(
 			array(
-				'post_title'  => __( 'Auto Draft' ),
+				'post_title'  => $default_title,
 				'post_type'   => $post_type,
 				'post_status' => 'auto-draft',
 			),
diff --git a/tests/phpunit/tests/admin/includesPost.php b/tests/phpunit/tests/admin/includesPost.php
index de7b42f5eb15a..86a11c9bee504 100644
--- a/tests/phpunit/tests/admin/includesPost.php
+++ b/tests/phpunit/tests/admin/includesPost.php
@@ -1325,4 +1325,22 @@ public function test_user_get_refreshed_metabox_nonce() {
 		$this->assertNotEmpty( $response['wp-refresh-metabox-loader-nonces']['replace']['_wpnonce'] );
 		$this->assertNotEmpty( $response['wp-refresh-metabox-loader-nonces']['replace']['metabox_loader_nonce'] );
 	}
+
+	/**
+	 * Ensure default title is set to "(no title supported)" when CPT lacks title support.
+	 *
+	 * @ticket 45516
+	 */
+	public function test_no_title_supported_when_title_not_supported() {
+		register_post_type(
+			'no_title',
+			array(
+				'supports' => array( 'editor' ),
+			)
+		);
+
+		$default_post = get_default_post_to_edit( 'no_title', true );
+		$post         = get_post( $default_post->ID );
+		$this->assertSame( '(no title supported)', $post->post_title );
+	}
 }