diff --git a/CHANGELOG.md b/CHANGELOG.md
index 66d75fa655..b5be15a96f 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -9,6 +9,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - `opentelemetry-instrumentation` Fixed cases where trying to use an instrumentation package without the
   target library was crashing auto instrumentation agent.
   ([#530](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/530))
+- `opentelemetry-instrumentation-django` Migrated Django middleware to new-style.
+  ([#533](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/533))
 
 ## [0.22b0](https://github.com/open-telemetry/opentelemetry-python/releases/tag/v1.3.0-0.22b0) - 2021-06-01
 
diff --git a/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/middleware.py b/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/middleware.py
index f37372d721..6846aa9fa8 100644
--- a/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/middleware.py
+++ b/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/middleware.py
@@ -42,11 +42,6 @@
 except ImportError:
     from django.urls import Resolver404, resolve
 
-try:
-    from django.utils.deprecation import MiddlewareMixin
-except ImportError:
-    MiddlewareMixin = object
-
 _logger = getLogger(__name__)
 _attributes_by_preference = [
     [
@@ -70,7 +65,7 @@
 ]
 
 
-class _DjangoMiddleware(MiddlewareMixin):
+class _DjangoMiddleware:
     """Django Middleware for OpenTelemetry"""
 
     _environ_activation_key = (
@@ -89,6 +84,9 @@ class _DjangoMiddleware(MiddlewareMixin):
         [Span, HttpRequest, HttpResponse], None
     ] = None
 
+    def __init__(self, get_response):
+        self.get_response = get_response
+
     @staticmethod
     def _get_span_name(request):
         try:
@@ -111,6 +109,11 @@ def _get_span_name(request):
         except Resolver404:
             return "HTTP {}".format(request.method)
 
+    def __call__(self, request):
+        self.process_request(request)
+        response = self.get_response(request)
+        return self.process_response(request, response)
+
     def process_request(self, request):
         # request.META is a dictionary containing all available HTTP headers
         # Read more about request.META here: