diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index 78c2dc916014..58cb2514889b 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -2685,7 +2685,7 @@
 //#define NEOPIXEL_LED
 #if ENABLED(NEOPIXEL_LED)
   #define NEOPIXEL_TYPE   NEO_GRBW // NEO_GRBW / NEO_GRB - four/three channel driver type (defined in Adafruit_NeoPixel.h)
-  #define NEOPIXEL_PIN     4       // LED driving pin
+  //#define NEOPIXEL_PIN     4     // LED driving pin
   //#define NEOPIXEL2_TYPE NEOPIXEL_TYPE
   //#define NEOPIXEL2_PIN    5
   #define NEOPIXEL_PIXELS 30       // Number of LEDs in the strip. (Longest strip when NEOPIXEL2_SEPARATE is disabled.)
@@ -2703,10 +2703,11 @@
     //#define NEOPIXEL2_INSERIES      // Default behavior is NeoPixel 2 in parallel
   #endif
 
-  // Use a single NeoPixel LED for static (background) lighting
-  //#define NEOPIXEL_BKGD_LED_INDEX  0               // Index of the LED to use
-  //#define NEOPIXEL_BKGD_COLOR { 255, 255, 255, 0 } // R, G, B, W
-  //#define NEOPIXEL_BKGD_ALWAYS_ON                  // Keep the backlight on when other NeoPixels are off
+  // Use some of the NeoPixel LEDs for static (background) lighting
+  //#define NEOPIXEL_BKGD_INDEX_FIRST  0              // Index of the first background LED
+  //#define NEOPIXEL_BKGD_INDEX_LAST   5              // Index of the last background LED
+  //#define NEOPIXEL_BKGD_COLOR { 255, 255, 255, 0 }  // R, G, B, W
+  //#define NEOPIXEL_BKGD_ALWAYS_ON                   // Keep the backlight on when other NeoPixels are off
 #endif
 
 /**
diff --git a/Marlin/src/feature/caselight.cpp b/Marlin/src/feature/caselight.cpp
index ec4ad99c75eb..1baef6d46845 100644
--- a/Marlin/src/feature/caselight.cpp
+++ b/Marlin/src/feature/caselight.cpp
@@ -65,9 +65,7 @@ void CaseLight::update(const bool sflag) {
   #endif
 
   #if CASE_LIGHT_IS_COLOR_LED
-
-    leds.set_color(MakeLEDColor(color.r, color.g, color.b, color.w, n10ct));
-
+    leds.set_color(LEDColor(color.r, color.g, color.b OPTARG(HAS_WHITE_LED, color.w), n10ct));
   #else // !CASE_LIGHT_IS_COLOR_LED
 
     #if CASELIGHT_USES_BRIGHTNESS
diff --git a/Marlin/src/feature/leds/leds.cpp b/Marlin/src/feature/leds/leds.cpp
index c9178effa88c..328daa626d46 100644
--- a/Marlin/src/feature/leds/leds.cpp
+++ b/Marlin/src/feature/leds/leds.cpp
@@ -47,9 +47,10 @@
 #endif
 
 #if ENABLED(LED_COLOR_PRESETS)
-  const LEDColor LEDLights::defaultLEDColor = MakeLEDColor(
-    LED_USER_PRESET_RED, LED_USER_PRESET_GREEN, LED_USER_PRESET_BLUE,
-    LED_USER_PRESET_WHITE, LED_USER_PRESET_BRIGHTNESS
+  const LEDColor LEDLights::defaultLEDColor = LEDColor(
+    LED_USER_PRESET_RED, LED_USER_PRESET_GREEN, LED_USER_PRESET_BLUE
+    OPTARG(HAS_WHITE_LED, LED_USER_PRESET_WHITE)
+    OPTARG(NEOPIXEL_LED, LED_USER_PRESET_BRIGHTNESS)
   );
 #endif
 
@@ -75,34 +76,35 @@ void LEDLights::setup() {
 }
 
 void LEDLights::set_color(const LEDColor &incol
-  OPTARG(NEOPIXEL_LED, bool isSequence/*=false*/)
+  OPTARG(NEOPIXEL_IS_SEQUENTIAL, bool isSequence/*=false*/)
 ) {
 
   #if ENABLED(NEOPIXEL_LED)
 
     const uint32_t neocolor = LEDColorWhite() == incol
                             ? neo.Color(NEO_WHITE)
-                            : neo.Color(incol.r, incol.g, incol.b, incol.w);
-    static uint16_t nextLed = 0;
-
-    #ifdef NEOPIXEL_BKGD_LED_INDEX
-      if (NEOPIXEL_BKGD_LED_INDEX == nextLed) {
-        neo.set_color_background();
-        if (++nextLed >= neo.pixels()) {
-          nextLed = 0;
-          return;
+                            : neo.Color(incol.r, incol.g, incol.b OPTARG(HAS_WHITE_LED, incol.w));
+
+    #if ENABLED(NEOPIXEL_IS_SEQUENTIAL)
+      static uint16_t nextLed = 0;
+      #ifdef NEOPIXEL_BKGD_INDEX_FIRST
+        while (WITHIN(nextLed, NEOPIXEL_BKGD_INDEX_FIRST, NEOPIXEL_BKGD_INDEX_LAST)) {
+          neo.reset_background_color();
+          if (++nextLed >= neo.pixels()) { nextLed = 0; return; }
         }
-      }
+      #endif
     #endif
 
     neo.set_brightness(incol.i);
 
-    if (isSequence) {
-      neo.set_pixel_color(nextLed, neocolor);
-      neo.show();
-      if (++nextLed >= neo.pixels()) nextLed = 0;
-      return;
-    }
+    #if ENABLED(NEOPIXEL_IS_SEQUENTIAL)
+      if (isSequence) {
+        neo.set_pixel_color(nextLed, neocolor);
+        neo.show();
+        if (++nextLed >= neo.pixels()) nextLed = 0;
+        return;
+      }
+    #endif
 
     neo.set_color(neocolor);
 
@@ -167,9 +169,10 @@ void LEDLights::set_color(const LEDColor &incol
 #if ENABLED(NEOPIXEL2_SEPARATE)
 
   #if ENABLED(NEO2_COLOR_PRESETS)
-    const LEDColor LEDLights2::defaultLEDColor = MakeLEDColor(
-      NEO2_USER_PRESET_RED, NEO2_USER_PRESET_GREEN, NEO2_USER_PRESET_BLUE,
-      NEO2_USER_PRESET_WHITE, NEO2_USER_PRESET_BRIGHTNESS
+    const LEDColor LEDLights2::defaultLEDColor = LEDColor(
+      LED_USER_PRESET_RED, LED_USER_PRESET_GREEN, LED_USER_PRESET_BLUE
+      OPTARG(HAS_WHITE_LED2, LED_USER_PRESET_WHITE)
+      OPTARG(NEOPIXEL_LED, LED_USER_PRESET_BRIGHTNESS)
     );
   #endif
 
@@ -188,7 +191,7 @@ void LEDLights::set_color(const LEDColor &incol
   void LEDLights2::set_color(const LEDColor &incol) {
     const uint32_t neocolor = LEDColorWhite() == incol
                             ? neo2.Color(NEO2_WHITE)
-                            : neo2.Color(incol.r, incol.g, incol.b, incol.w);
+                            : neo2.Color(incol.r, incol.g, incol.b OPTARG(HAS_WHITE_LED2, incol.w));
     neo2.set_brightness(incol.i);
     neo2.set_color(neocolor);
 
diff --git a/Marlin/src/feature/leds/leds.h b/Marlin/src/feature/leds/leds.h
index 4157ff816eec..74964b51a8e4 100644
--- a/Marlin/src/feature/leds/leds.h
+++ b/Marlin/src/feature/leds/leds.h
@@ -29,15 +29,17 @@
 
 #include <string.h>
 
-#if ENABLED(NEOPIXEL_LED)
-  #include "neopixel.h"
-#endif
-
 // A white component can be passed
-#if ANY(RGBW_LED, NEOPIXEL_LED, PCA9632_RGBW)
+#if EITHER(RGBW_LED, PCA9632_RGBW)
   #define HAS_WHITE_LED 1
 #endif
 
+#if ENABLED(NEOPIXEL_LED)
+  #define _NEOPIXEL_INCLUDE_
+  #include "neopixel.h"
+  #undef _NEOPIXEL_INCLUDE_
+#endif
+
 /**
  * LEDcolor type for use with leds.set_color
  */
@@ -84,9 +86,8 @@ typedef struct LEDColor {
 } LEDColor;
 
 /**
- * Color helpers and presets
+ * Color presets
  */
-#define MakeLEDColor(R,G,B,W,I)   LEDColor(R, G, B OPTARG(HAS_WHITE_LED, W) OPTARG(NEOPIXEL_LED, I))
 
 #define LEDColorOff()             LEDColor(  0,   0,   0)
 #define LEDColorRed()             LEDColor(255,   0,   0)
@@ -114,15 +115,15 @@ class LEDLights {
   static void setup(); // init()
 
   static void set_color(const LEDColor &color
-    OPTARG(NEOPIXEL_LED, bool isSequence=false)
+    OPTARG(NEOPIXEL_IS_SEQUENTIAL, bool isSequence=false)
   );
 
   static inline void set_color(uint8_t r, uint8_t g, uint8_t b
     OPTARG(HAS_WHITE_LED, uint8_t w=0)
     OPTARG(NEOPIXEL_LED, uint8_t i=NEOPIXEL_BRIGHTNESS)
-    OPTARG(NEOPIXEL_LED, bool isSequence=false)
+    OPTARG(NEOPIXEL_IS_SEQUENTIAL, bool isSequence=false)
   ) {
-    set_color(MakeLEDColor(r, g, b, w, i) OPTARG(NEOPIXEL_LED, isSequence));
+    set_color(LEDColor(r, g, b OPTARG(HAS_WHITE_LED, w) OPTARG(NEOPIXEL_LED, i)) OPTARG(NEOPIXEL_IS_SEQUENTIAL, isSequence));
   }
 
   static inline void set_off()   { set_color(LEDColorOff()); }
@@ -180,8 +181,14 @@ extern LEDLights leds;
 
     static void set_color(const LEDColor &color);
 
-    inline void set_color(uint8_t r, uint8_t g, uint8_t b, uint8_t w=0, uint8_t i=NEOPIXEL2_BRIGHTNESS) {
-      set_color(MakeLEDColor(r, g, b, w, i));
+    static inline void set_color(uint8_t r, uint8_t g, uint8_t b
+      OPTARG(HAS_WHITE_LED, uint8_t w=0)
+      OPTARG(NEOPIXEL_LED, uint8_t i=NEOPIXEL_BRIGHTNESS)
+    ) {
+      set_color(LEDColor(r, g, b
+        OPTARG(HAS_WHITE_LED, w)
+        OPTARG(NEOPIXEL_LED, i)
+      ));
     }
 
     static inline void set_off()   { set_color(LEDColorOff()); }
diff --git a/Marlin/src/feature/leds/neopixel.cpp b/Marlin/src/feature/leds/neopixel.cpp
index bdd22837ada5..2654e9a1df5a 100644
--- a/Marlin/src/feature/leds/neopixel.cpp
+++ b/Marlin/src/feature/leds/neopixel.cpp
@@ -28,7 +28,7 @@
 
 #if ENABLED(NEOPIXEL_LED)
 
-#include "neopixel.h"
+#include "leds.h"
 
 #if EITHER(NEOPIXEL_STARTUP_TEST, NEOPIXEL2_STARTUP_TEST)
   #include "../../core/utility.h"
@@ -37,17 +37,21 @@
 Marlin_NeoPixel neo;
 int8_t Marlin_NeoPixel::neoindex;
 
-Adafruit_NeoPixel Marlin_NeoPixel::adaneo1(NEOPIXEL_PIXELS, NEOPIXEL_PIN, NEOPIXEL_TYPE + NEO_KHZ800)
-  #if CONJOINED_NEOPIXEL
-    , Marlin_NeoPixel::adaneo2(NEOPIXEL_PIXELS, NEOPIXEL2_PIN, NEOPIXEL2_TYPE + NEO_KHZ800)
-  #endif
-;
+Adafruit_NeoPixel Marlin_NeoPixel::adaneo1(NEOPIXEL_PIXELS, NEOPIXEL_PIN, NEOPIXEL_TYPE + NEO_KHZ800);
+#if CONJOINED_NEOPIXEL
+  Adafruit_NeoPixel Marlin_NeoPixel::adaneo2(NEOPIXEL_PIXELS, NEOPIXEL2_PIN, NEOPIXEL2_TYPE + NEO_KHZ800);
+#endif
 
-#ifdef NEOPIXEL_BKGD_LED_INDEX
+#ifdef NEOPIXEL_BKGD_INDEX_FIRST
+
+  void Marlin_NeoPixel::set_background_color(uint8_t r, uint8_t g, uint8_t b, uint8_t w) {
+    for  (int background_led = NEOPIXEL_BKGD_INDEX_FIRST; background_led <= NEOPIXEL_BKGD_INDEX_LAST; background_led++)
+      set_pixel_color(background_led, adaneo1.Color(r, g, b, w));
+  }
 
-  void Marlin_NeoPixel::set_color_background() {
-    uint8_t background_color[4] = NEOPIXEL_BKGD_COLOR;
-    set_pixel_color(NEOPIXEL_BKGD_LED_INDEX, adaneo1.Color(background_color[0], background_color[1], background_color[2], background_color[3]));
+  void Marlin_NeoPixel::reset_background_color() {
+    constexpr uint8_t background_color[4] = NEOPIXEL_BKGD_COLOR;
+    set_background_color(background_color[0], background_color[1], background_color[2], background_color[3]);
   }
 
 #endif
@@ -59,9 +63,10 @@ void Marlin_NeoPixel::set_color(const uint32_t color) {
   }
   else {
     for (uint16_t i = 0; i < pixels(); ++i) {
-      #ifdef NEOPIXEL_BKGD_LED_INDEX
-        if (i == NEOPIXEL_BKGD_LED_INDEX && TERN(NEOPIXEL_BKGD_ALWAYS_ON, true, color != 0x000000)) {
-          set_color_background();
+      #ifdef NEOPIXEL_BKGD_INDEX_FIRST
+        if (i == NEOPIXEL_BKGD_INDEX_FIRST && TERN(NEOPIXEL_BKGD_ALWAYS_ON, true, color != 0x000000)) {
+          reset_background_color();
+          i += NEOPIXEL_BKGD_INDEX_LAST - (NEOPIXEL_BKGD_INDEX_FIRST);
           continue;
         }
       #endif
@@ -90,35 +95,22 @@ void Marlin_NeoPixel::init() {
     safe_delay(500);
     set_color_startup(adaneo1.Color(0, 0, 255, 0));  // blue
     safe_delay(500);
+    #if HAS_WHITE_LED
+      set_color_startup(adaneo1.Color(0, 0, 0, 255));  // white
+      safe_delay(500);
+    #endif
   #endif
 
-  #ifdef NEOPIXEL_BKGD_LED_INDEX
-    set_color_background();
-  #endif
-
-  #if ENABLED(LED_USER_PRESET_STARTUP)
-    set_color(adaneo1.Color(LED_USER_PRESET_RED, LED_USER_PRESET_GREEN, LED_USER_PRESET_BLUE, LED_USER_PRESET_WHITE));
-  #else
-    set_color(adaneo1.Color(0, 0, 0, 0));
+  #ifdef NEOPIXEL_BKGD_INDEX_FIRST
+    reset_background_color();
   #endif
-}
 
-#if 0
-bool Marlin_NeoPixel::set_led_color(const uint8_t r, const uint8_t g, const uint8_t b, const uint8_t w, const uint8_t p) {
-  const uint32_t color = adaneo1.Color(r, g, b, w);
-  set_brightness(p);
-  #if DISABLED(NEOPIXEL_IS_SEQUENTIAL)
-    set_color(color);
-    return false;
-  #else
-    static uint16_t nextLed = 0;
-    set_pixel_color(nextLed, color);
-    show();
-    if (++nextLed >= pixels()) nextLed = 0;
-    return true;
-  #endif
+  set_color(adaneo1.Color
+    TERN(LED_USER_PRESET_STARTUP,
+      (LED_USER_PRESET_RED, LED_USER_PRESET_GREEN, LED_USER_PRESET_BLUE, LED_USER_PRESET_WHITE),
+      (0, 0, 0, 0))
+  );
 }
-#endif
 
 #if ENABLED(NEOPIXEL2_SEPARATE)
 
@@ -158,13 +150,17 @@ bool Marlin_NeoPixel::set_led_color(const uint8_t r, const uint8_t g, const uint
       safe_delay(500);
       set_color_startup(adaneo.Color(0, 0, 255, 0));  // blue
       safe_delay(500);
+      #if HAS_WHITE_LED2
+        set_color_startup(adaneo.Color(0, 0, 0, 255));  // white
+        safe_delay(500);
+      #endif
     #endif
 
-    #if ENABLED(NEO2_USER_PRESET_STARTUP)
-      set_color(adaneo.Color(NEO2_USER_PRESET_RED, NEO2_USER_PRESET_GREEN, NEO2_USER_PRESET_BLUE, NEO2_USER_PRESET_WHITE));
-    #else
-      set_color(adaneo.Color(0, 0, 0, 0));
-    #endif
+    set_color(adaneo.Color
+      TERN(NEO2_USER_PRESET_STARTUP,
+        (NEO2_USER_PRESET_RED, NEO2_USER_PRESET_GREEN, NEO2_USER_PRESET_BLUE, NEO2_USER_PRESET_WHITE),
+        (0, 0, 0, 0))
+    );
   }
 
 #endif // NEOPIXEL2_SEPARATE
diff --git a/Marlin/src/feature/leds/neopixel.h b/Marlin/src/feature/leds/neopixel.h
index acf2e7f54d3b..e577948cd851 100644
--- a/Marlin/src/feature/leds/neopixel.h
+++ b/Marlin/src/feature/leds/neopixel.h
@@ -25,6 +25,10 @@
  * NeoPixel support
  */
 
+#ifndef _NEOPIXEL_INCLUDE_
+  #error "Always include 'leds.h' and not 'neopixel.h' directly."
+#endif
+
 // ------------------------
 // Includes
 // ------------------------
@@ -38,24 +42,24 @@
 // Defines
 // ------------------------
 
-#if defined(NEOPIXEL2_TYPE) && NEOPIXEL2_TYPE != NEOPIXEL_TYPE && DISABLED(NEOPIXEL2_SEPARATE)
-  #define MULTIPLE_NEOPIXEL_TYPES 1
-#endif
+#define _NEO_IS_RGB(N) (N == NEO_RGB || N == NEO_RBG || N == NEO_GRB || N == NEO_GBR || N == NEO_BRG || N == NEO_BGR)
 
-#if EITHER(MULTIPLE_NEOPIXEL_TYPES, NEOPIXEL2_INSERIES)
-  #define CONJOINED_NEOPIXEL 1
+#if !_NEO_IS_RGB(NEOPIXEL_TYPE)
+  #define HAS_WHITE_LED 1
 #endif
 
-#if NEOPIXEL_TYPE == NEO_RGB || NEOPIXEL_TYPE == NEO_RBG || NEOPIXEL_TYPE == NEO_GRB || NEOPIXEL_TYPE == NEO_GBR || NEOPIXEL_TYPE == NEO_BRG || NEOPIXEL_TYPE == NEO_BGR
-  #define NEOPIXEL_IS_RGB 1
+#if HAS_WHITE_LED
+  #define NEO_WHITE 0, 0, 0, 255
 #else
-  #define NEOPIXEL_IS_RGBW 1
+  #define NEO_WHITE 255, 255, 255
 #endif
 
-#if NEOPIXEL_IS_RGB
-  #define NEO_WHITE 255, 255, 255, 0
-#else
-  #define NEO_WHITE 0, 0, 0, 255
+#if defined(NEOPIXEL2_TYPE) && NEOPIXEL2_TYPE != NEOPIXEL_TYPE && DISABLED(NEOPIXEL2_SEPARATE)
+  #define MULTIPLE_NEOPIXEL_TYPES 1
+#endif
+
+#if EITHER(MULTIPLE_NEOPIXEL_TYPES, NEOPIXEL2_INSERIES)
+  #define CONJOINED_NEOPIXEL 1
 #endif
 
 // ------------------------
@@ -64,11 +68,10 @@
 
 class Marlin_NeoPixel {
 private:
-  static Adafruit_NeoPixel adaneo1
-    #if CONJOINED_NEOPIXEL
-      , adaneo2
-    #endif
-  ;
+  static Adafruit_NeoPixel adaneo1;
+  #if CONJOINED_NEOPIXEL
+    static Adafruit_NeoPixel adaneo2;
+  #endif
 
 public:
   static int8_t neoindex;
@@ -78,8 +81,9 @@ class Marlin_NeoPixel {
 
   static void set_color(const uint32_t c);
 
-  #ifdef NEOPIXEL_BKGD_LED_INDEX
-    static void set_color_background();
+  #ifdef NEOPIXEL_BKGD_INDEX_FIRST
+    static void set_background_color(uint8_t r, uint8_t g, uint8_t b, uint8_t w);
+    static void reset_background_color();
   #endif
 
   static inline void begin() {
@@ -93,9 +97,7 @@ class Marlin_NeoPixel {
       else adaneo1.setPixelColor(n, c);
     #else
       adaneo1.setPixelColor(n, c);
-      #if MULTIPLE_NEOPIXEL_TYPES
-        adaneo2.setPixelColor(n, c);
-      #endif
+      TERN_(MULTIPLE_NEOPIXEL_TYPES, adaneo2.setPixelColor(n, c));
     #endif
   }
 
@@ -120,15 +122,13 @@ class Marlin_NeoPixel {
     TERN_(HAS_PAUSE_SERVO_OUTPUT, RESUME_SERVO_OUTPUT());
   }
 
-  #if 0
-    bool set_led_color(const uint8_t r, const uint8_t g, const uint8_t b, const uint8_t w, const uint8_t p);
-  #endif
-
   // Accessors
-  static inline uint16_t pixels() { TERN(NEOPIXEL2_INSERIES, return adaneo1.numPixels() * 2, return adaneo1.numPixels()); }
+  static inline uint16_t pixels() { return adaneo1.numPixels() * TERN1(NEOPIXEL2_INSERIES, 2); }
+
   static inline uint8_t brightness() { return adaneo1.getBrightness(); }
-  static inline uint32_t Color(uint8_t r, uint8_t g, uint8_t b, uint8_t w) {
-    return adaneo1.Color(r, g, b, w);
+
+  static inline uint32_t Color(uint8_t r, uint8_t g, uint8_t b OPTARG(HAS_WHITE_LED, uint8_t w)) {
+    return adaneo1.Color(r, g, b OPTARG(HAS_WHITE_LED, w));
   }
 };
 
@@ -137,15 +137,12 @@ extern Marlin_NeoPixel neo;
 // Neo pixel channel 2
 #if ENABLED(NEOPIXEL2_SEPARATE)
 
-  #if NEOPIXEL2_TYPE == NEO_RGB || NEOPIXEL2_TYPE == NEO_RBG || NEOPIXEL2_TYPE == NEO_GRB || NEOPIXEL2_TYPE == NEO_GBR || NEOPIXEL2_TYPE == NEO_BRG || NEOPIXEL2_TYPE == NEO_BGR
+  #if _NEO_IS_RGB(NEOPIXEL2_TYPE)
     #define NEOPIXEL2_IS_RGB 1
+    #define NEO2_WHITE 255, 255, 255
   #else
     #define NEOPIXEL2_IS_RGBW 1
-  #endif
-
-  #if NEOPIXEL2_IS_RGB
-    #define NEO2_WHITE 255, 255, 255, 0
-  #else
+    #define HAS_WHITE_LED2 1      // A white component can be passed for NEOPIXEL2
     #define NEO2_WHITE 0, 0, 0, 255
   #endif
 
@@ -172,11 +169,13 @@ extern Marlin_NeoPixel neo;
     // Accessors
     static inline uint16_t pixels() { return adaneo.numPixels();}
     static inline uint8_t brightness() { return adaneo.getBrightness(); }
-    static inline uint32_t Color(uint8_t r, uint8_t g, uint8_t b, uint8_t w) {
-      return adaneo.Color(r, g, b, w);
+    static inline uint32_t Color(uint8_t r, uint8_t g, uint8_t b OPTARG(HAS_WHITE_LED2, uint8_t w)) {
+      return adaneo.Color(r, g, b OPTARG(HAS_WHITE_LED2, w));
     }
   };
 
   extern Marlin_NeoPixel2 neo2;
 
 #endif // NEOPIXEL2_SEPARATE
+
+#undef _NEO_IS_RGB
diff --git a/Marlin/src/feature/leds/printer_event_leds.cpp b/Marlin/src/feature/leds/printer_event_leds.cpp
index 4765f82e56f6..e6407a6320a5 100644
--- a/Marlin/src/feature/leds/printer_event_leds.cpp
+++ b/Marlin/src/feature/leds/printer_event_leds.cpp
@@ -45,12 +45,10 @@ PrinterEventLEDs printerEventLEDs;
     return (uint8_t)map(constrain(current, start, target), start, target, 0, 255);
   }
 
-  inline void pel_set_rgb(const uint8_t r, const uint8_t g, const uint8_t b) {
+  inline void pel_set_rgb(const uint8_t r, const uint8_t g, const uint8_t b OPTARG(HAS_WHITE_LED, const uint8_t w=0)) {
     leds.set_color(
-      MakeLEDColor(r, g, b, 0, neo.brightness())
-      #if ENABLED(NEOPIXEL_IS_SEQUENTIAL)
-        , true
-      #endif
+      LEDColor(r, g, b OPTARG(HAS_WHITE_LED, w) OPTARG(NEOPIXEL_LED, neo.brightness()))
+      OPTARG(NEOPIXEL_IS_SEQUENTIAL, true)
     );
   }
 
diff --git a/Marlin/src/gcode/feature/leds/M150.cpp b/Marlin/src/gcode/feature/leds/M150.cpp
index cf09bf14ead7..5d175ea8f779 100644
--- a/Marlin/src/gcode/feature/leds/M150.cpp
+++ b/Marlin/src/gcode/feature/leds/M150.cpp
@@ -66,12 +66,12 @@ void GcodeSuite::M150() {
     #endif
   #endif
 
-  const LEDColor color = MakeLEDColor(
+  const LEDColor color = LEDColor(
     parser.seen('R') ? (parser.has_value() ? parser.value_byte() : 255) : 0,
     parser.seen('U') ? (parser.has_value() ? parser.value_byte() : 255) : 0,
-    parser.seen('B') ? (parser.has_value() ? parser.value_byte() : 255) : 0,
-    parser.seen('W') ? (parser.has_value() ? parser.value_byte() : 255) : 0,
-    parser.seen('P') ? (parser.has_value() ? parser.value_byte() : 255) : brightness
+    parser.seen('B') ? (parser.has_value() ? parser.value_byte() : 255) : 0
+    OPTARG(HAS_WHITE_LED, parser.seen('W') ? (parser.has_value() ? parser.value_byte() : 255) : 0)
+    OPTARG(NEOPIXEL_LED, parser.seen('P') ? (parser.has_value() ? parser.value_byte() : 255) : brightness)
   );
 
   #if ENABLED(NEOPIXEL2_SEPARATE)
diff --git a/Marlin/src/inc/Conditionals_LCD.h b/Marlin/src/inc/Conditionals_LCD.h
index 8001674dc4d5..f29b5af66ff8 100644
--- a/Marlin/src/inc/Conditionals_LCD.h
+++ b/Marlin/src/inc/Conditionals_LCD.h
@@ -1303,3 +1303,10 @@
 #else
   #define COORDINATE_OKAY(N,L,H) true
 #endif
+
+/**
+ * LED Backlight INDEX END
+ */
+#if defined(NEOPIXEL_BKGD_INDEX_FIRST) && !defined(NEOPIXEL_BKGD_INDEX_LAST)
+  #define NEOPIXEL_BKGD_INDEX_LAST NEOPIXEL_BKGD_INDEX_FIRST
+#endif
diff --git a/Marlin/src/inc/SanityCheck.h b/Marlin/src/inc/SanityCheck.h
index 897cb2824fc9..3d73c991eca0 100644
--- a/Marlin/src/inc/SanityCheck.h
+++ b/Marlin/src/inc/SanityCheck.h
@@ -562,6 +562,8 @@
   #error "CUSTOM_USER_MENUS has been replaced by CUSTOM_MENU_MAIN and CUSTOM_MENU_CONFIG."
 #elif defined(MKS_LCD12864)
   #error "MKS_LCD12864 is now MKS_LCD12864A or MKS_LCD12864B."
+#elif defined(NEOPIXEL_BKGD_LED_INDEX)
+  #error "NEOPIXEL_BKGD_LED_INDEX is now NEOPIXEL_BKGD_INDEX_FIRST."
 #endif
 
 /**
diff --git a/Marlin/src/lcd/marlinui.cpp b/Marlin/src/lcd/marlinui.cpp
index ba3abc0e2dd2..d73dab6e18e2 100644
--- a/Marlin/src/lcd/marlinui.cpp
+++ b/Marlin/src/lcd/marlinui.cpp
@@ -636,8 +636,8 @@ void MarlinUI::kill_screen(PGM_P lcd_error, PGM_P lcd_component) {
   // RED ALERT. RED ALERT.
   #ifdef LED_BACKLIGHT_TIMEOUT
     leds.set_color(LEDColorRed());
-    #ifdef NEOPIXEL_BKGD_LED_INDEX
-      neo.set_pixel_color(NEOPIXEL_BKGD_LED_INDEX, 255, 0, 0, 0);
+    #ifdef NEOPIXEL_BKGD_INDEX_FIRST
+      neo.set_background_color(255, 0, 0, 0);
       neo.show();
     #endif
   #endif
diff --git a/Marlin/src/lcd/menu/menu_led.cpp b/Marlin/src/lcd/menu/menu_led.cpp
index 5ab5e8a9d8dc..284e80c931b7 100644
--- a/Marlin/src/lcd/menu/menu_led.cpp
+++ b/Marlin/src/lcd/menu/menu_led.cpp
@@ -84,18 +84,20 @@
     EDIT_ITEM(uint8, MSG_INTENSITY_R, &leds.color.r, 0, 255, leds.update, true);
     EDIT_ITEM(uint8, MSG_INTENSITY_G, &leds.color.g, 0, 255, leds.update, true);
     EDIT_ITEM(uint8, MSG_INTENSITY_B, &leds.color.b, 0, 255, leds.update, true);
-    #if EITHER(RGBW_LED, NEOPIXEL_LED)
+    #if HAS_WHITE_LED
       EDIT_ITEM(uint8, MSG_INTENSITY_W, &leds.color.w, 0, 255, leds.update, true);
-      #if ENABLED(NEOPIXEL_LED)
-        EDIT_ITEM(uint8, MSG_LED_BRIGHTNESS, &leds.color.i, 0, 255, leds.update, true);
-      #endif
+    #endif
+    #if ENABLED(NEOPIXEL_LED)
+      EDIT_ITEM(uint8, MSG_LED_BRIGHTNESS, &leds.color.i, 0, 255, leds.update, true);
     #endif
     #if ENABLED(NEOPIXEL2_SEPARATE)
       STATIC_ITEM_N(MSG_LED_CHANNEL_N, 2, SS_DEFAULT|SS_INVERT);
       EDIT_ITEM(uint8, MSG_INTENSITY_R, &leds2.color.r, 0, 255, leds2.update, true);
       EDIT_ITEM(uint8, MSG_INTENSITY_G, &leds2.color.g, 0, 255, leds2.update, true);
       EDIT_ITEM(uint8, MSG_INTENSITY_B, &leds2.color.b, 0, 255, leds2.update, true);
-      EDIT_ITEM(uint8, MSG_INTENSITY_W, &leds2.color.w, 0, 255, leds2.update, true);
+      #if HAS_WHITE_LED2
+        EDIT_ITEM(uint8, MSG_INTENSITY_W, &leds2.color.w, 0, 255, leds2.update, true);
+      #endif
       EDIT_ITEM(uint8, MSG_NEO2_BRIGHTNESS, &leds2.color.i, 0, 255, leds2.update, true);
     #endif
     END_MENU();
diff --git a/buildroot/tests/DUE b/buildroot/tests/DUE
index d1601edf5ab7..9931776e0046 100755
--- a/buildroot/tests/DUE
+++ b/buildroot/tests/DUE
@@ -18,7 +18,7 @@ opt_enable S_CURVE_ACCELERATION EEPROM_SETTINGS GCODE_MACROS \
            ASSISTED_TRAMMING ASSISTED_TRAMMING_WIZARD REPORT_TRAMMING_MM ASSISTED_TRAMMING_WAIT_POSITION \
            EEPROM_SETTINGS SDSUPPORT BINARY_FILE_TRANSFER \
            BLINKM PCA9533 PCA9632 RGB_LED RGB_LED_R_PIN RGB_LED_G_PIN RGB_LED_B_PIN LED_CONTROL_MENU \
-           NEOPIXEL_LED CASE_LIGHT_ENABLE CASE_LIGHT_USE_NEOPIXEL CASE_LIGHT_USE_RGB_LED CASE_LIGHT_MENU \
+           NEOPIXEL_LED NEOPIXEL_PIN CASE_LIGHT_ENABLE CASE_LIGHT_USE_NEOPIXEL CASE_LIGHT_USE_RGB_LED CASE_LIGHT_MENU \
            NOZZLE_PARK_FEATURE ADVANCED_PAUSE_FEATURE FILAMENT_RUNOUT_DISTANCE_MM FILAMENT_RUNOUT_SENSOR \
            AUTO_BED_LEVELING_BILINEAR Z_MIN_PROBE_REPEATABILITY_TEST DEBUG_LEVELING_FEATURE \
            SKEW_CORRECTION SKEW_CORRECTION_FOR_Z SKEW_CORRECTION_GCODE CALIBRATION_GCODE \
diff --git a/buildroot/tests/LPC1768 b/buildroot/tests/LPC1768
index 92fda5448346..95a055d6951f 100755
--- a/buildroot/tests/LPC1768
+++ b/buildroot/tests/LPC1768
@@ -14,8 +14,10 @@ set -e
 #exec_test $1 $2 "Default Configuration" "$3"
 
 restore_configs
-opt_set MOTHERBOARD BOARD_RAMPS_14_RE_ARM_EFB NEOPIXEL_PIN P1_16 SERIAL_PORT_3 3
-opt_enable VIKI2 SDSUPPORT SDCARD_READONLY SERIAL_PORT_2 NEOPIXEL_LED
+opt_set MOTHERBOARD BOARD_RAMPS_14_RE_ARM_EFB  SERIAL_PORT_3 3 \
+        NEOPIXEL_TYPE NEO_GRB RGB_LED_R_PIN P2_12 RGB_LED_G_PIN P1_23 RGB_LED_B_PIN P1_22 RGB_LED_W_PIN P1_24
+opt_enable FYSETC_MINI_12864_2_1 SDSUPPORT SDCARD_READONLY SERIAL_PORT_2 RGBW_LED \
+           NEOPIXEL_LED NEOPIXEL_IS_SEQUENTIAL NEOPIXEL_STARTUP_TEST NEOPIXEL_BKGD_INDEX_FIRST NEOPIXEL_BKGD_INDEX_LAST NEOPIXEL_BKGD_COLOR NEOPIXEL_BKGD_ALWAYS_ON
 exec_test $1 $2 "ReARM EFB VIKI2, SDSUPPORT, 2 Serial ports (USB CDC + UART0), NeoPixel" "$3"
 
 #restore_configs
diff --git a/buildroot/tests/rambo b/buildroot/tests/rambo
index 9869b96b3478..ef38710e0dcc 100755
--- a/buildroot/tests/rambo
+++ b/buildroot/tests/rambo
@@ -22,7 +22,7 @@ opt_enable USE_ZMAX_PLUG REPRAP_DISCOUNT_SMART_CONTROLLER LCD_PROGRESS_BAR LCD_P
            PREHEAT_BEFORE_PROBING PROBING_HEATERS_OFF PROBING_FANS_OFF PROBING_STEPPERS_OFF WAIT_FOR_BED_HEATER \
            EEPROM_SETTINGS SDSUPPORT SD_REPRINT_LAST_SELECTED_FILE BINARY_FILE_TRANSFER \
            BLINKM PCA9533 PCA9632 RGB_LED RGB_LED_R_PIN RGB_LED_G_PIN RGB_LED_B_PIN LED_CONTROL_MENU \
-           NEOPIXEL_LED CASE_LIGHT_ENABLE CASE_LIGHT_USE_NEOPIXEL CASE_LIGHT_MENU \
+           NEOPIXEL_LED NEOPIXEL_PIN CASE_LIGHT_ENABLE CASE_LIGHT_USE_NEOPIXEL CASE_LIGHT_MENU \
            PID_PARAMS_PER_HOTEND PID_AUTOTUNE_MENU PID_EDIT_MENU LCD_SHOW_E_TOTAL \
            PRINTCOUNTER SERVICE_NAME_1 SERVICE_INTERVAL_1 LEVEL_BED_CORNERS LEVEL_CENTER_TOO \
            NOZZLE_PARK_FEATURE FILAMENT_RUNOUT_SENSOR FILAMENT_RUNOUT_DISTANCE_MM \