diff --git a/spyder/plugins/breakpoints/plugin.py b/spyder/plugins/breakpoints/plugin.py
index 25b71d657b6..5e155ff9e0c 100644
--- a/spyder/plugins/breakpoints/plugin.py
+++ b/spyder/plugins/breakpoints/plugin.py
@@ -18,7 +18,8 @@
 
 # Local imports
 from spyder.api.plugins import Plugins, SpyderDockablePlugin
-from spyder.api.plugin_registration.decorators import on_plugin_available
+from spyder.api.plugin_registration.decorators import (
+    on_plugin_available, on_plugin_teardown)
 from spyder.api.translations import get_translation
 from spyder.plugins.breakpoints.widgets.main_widget import BreakpointWidget
 from spyder.plugins.mainmenu.api import ApplicationMenus
@@ -140,6 +141,30 @@ def on_main_menu_available(self):
         debug_menu = mainmenu.get_application_menu(ApplicationMenus.Debug)
         mainmenu.add_item_to_application_menu(list_action, debug_menu)
 
+    @on_plugin_teardown(plugin=Plugins.Editor)
+    def on_editor_teardown(self):
+        widget = self.get_widget()
+        editor = self.get_plugin(Plugins.Editor)
+        list_action = self.get_action(BreakpointsActions.ListBreakpoints)
+
+        editor.breakpoints_saved.disconnect(self.set_data)
+        widget.sig_clear_all_breakpoints_requested.disconnect(
+            editor.clear_all_breakpoints)
+        widget.sig_clear_breakpoint_requested.disconnect(
+            editor.clear_breakpoint)
+        widget.sig_edit_goto_requested.disconnect(editor.load)
+        widget.sig_conditional_breakpoint_requested.disconnect(
+            editor.set_or_edit_conditional_breakpoint)
+
+        editor.pythonfile_dependent_actions.remove(list_action)
+
+    @on_plugin_teardown(plugin=Plugins.MainMenu)
+    def on_main_menu_teardown(self):
+        mainmenu = self.get_plugin(Plugins.MainMenu)
+        list_action = self.get_action(BreakpointsActions.ListBreakpoints)
+        debug_menu = mainmenu.get_application_menu(ApplicationMenus.Debug)
+        mainmenu.remove_item_from_application_menu(list_action, debug_menu)
+
     # --- Private API
     # ------------------------------------------------------------------------
     def _load_data(self):