diff --git a/spyder/api/widgets/menus.py b/spyder/api/widgets/menus.py
index f747d93d246..adde4df4799 100644
--- a/spyder/api/widgets/menus.py
+++ b/spyder/api/widgets/menus.py
@@ -166,6 +166,10 @@ def add_action(self: T, action: Union[SpyderAction, T],
         self._dirty = True
         self._actions_map[item_id] = action
 
+    def remove_action(self, item_id: str):
+        action = self._actions_map.pop(item_id)
+        self._actions.remove(action)
+
     def get_title(self):
         """
         Return the title for menu.
diff --git a/spyder/plugins/application/plugin.py b/spyder/plugins/application/plugin.py
index 5c1c56b9fbd..66895bcc3de 100644
--- a/spyder/plugins/application/plugin.py
+++ b/spyder/plugins/application/plugin.py
@@ -210,7 +210,36 @@ def _populate_help_menu_about_section(self):
             section=HelpMenuSections.About)
 
     def _depopulate_help_menu(self):
-        pass
+        self._depopulate_help_menu_documentation_section()
+        self._depopulate_help_menu_support_section()
+        self._depopulate_help_menu_about_section()
+
+    def _depopulate_help_menu_documentation_section(self):
+        mainmenu = self.get_plugin(Plugins.MainMenu)
+        for documentation_action in [
+                ApplicationActions.SpyderDocumentationAction,
+                ApplicationActions.SpyderDocumentationVideoAction]:
+            mainmenu.remove_item_from_application_menu(
+                documentation_action,
+                menu_id=ApplicationMenus.Help)
+
+    def _depopulate_help_menu_support_section(self):
+        """Remove Spyder base support actions from the Help main menu."""
+        mainmenu = self.get_plugin(Plugins.MainMenu)
+        for support_action in [
+                ApplicationActions.SpyderTroubleshootingAction,
+                ApplicationActions.SpyderDependenciesAction,
+                ApplicationActions.SpyderCheckUpdatesAction,
+                ApplicationActions.SpyderSupportAction]:
+            mainmenu.remove_item_from_application_menu(
+                support_action,
+                menu_id=ApplicationMenus.Help)
+
+    def _depopulate_help_menu_about_section(self):
+        mainmenu = self.get_plugin(Plugins.MainMenu)
+        mainmenu.remove_item_from_application_menu(
+            ApplicationActions.SpyderAbout,
+            menu_id=ApplicationMenus.Help)
 
     # ---- Public API
     # ------------------------------------------------------------------------
diff --git a/spyder/plugins/mainmenu/plugin.py b/spyder/plugins/mainmenu/plugin.py
index 63e7d6df023..f65b3475812 100644
--- a/spyder/plugins/mainmenu/plugin.py
+++ b/spyder/plugins/mainmenu/plugin.py
@@ -262,6 +262,52 @@ def add_item_to_application_menu(self, item: ItemType,
                 menu.add_action(item, section=section, before=before,
                                 before_section=before_section, omit_id=omit_id)
 
+    def remove_item_from_application_menu(self, item_id: str,
+                                          menu_id: Optional[str] = None):
+        """
+        Remove action or widget from given application menu by id.
+
+        Parameters
+        ----------
+        item_id: str
+            The item identifier to remove from the given menu.
+        menu_id: str or None
+            The application menu unique string identifier.
+        """
+        if menu_id not in self._APPLICATION_MENUS:
+            raise SpyderAPIError('{} is not a valid menu_id'.format(menu_id))
+
+        # TODO: For now just add the item to the bottom for non-migrated menus.
+        #       Temporal solution while migration is complete
+        app_menu_actions = {
+            ApplicationMenus.Edit: self._main.edit_menu_actions,
+            ApplicationMenus.Search: self._main.search_menu_actions,
+            ApplicationMenus.Source: self._main.source_menu_actions,
+            ApplicationMenus.Run: self._main.run_menu_actions,
+            ApplicationMenus.Debug: self._main.debug_menu_actions,
+        }
+
+        menu = self.get_application_menu(menu_id)
+
+        if menu_id in app_menu_actions:
+            actions = app_menu_actions[menu_id]  # type: list
+            position = None
+            for i, action in enumerate(actions):
+                this_item_id = None
+                if (isinstance(action, SpyderAction) or
+                        hasattr(action, 'action_id')):
+                    this_item_id = action.action_id
+                elif (isinstance(action, SpyderMenu) or
+                        hasattr(action, 'menu_id')):
+                    this_item_id = action.menu_id
+                if this_item_id is not None and this_item_id == item_id:
+                    position = i
+                    break
+            if position is not None:
+                actions.pop(position)
+        else:
+            menu.remove_action(item_id)
+
     def get_application_menu(self, menu_id: str) -> SpyderMenu:
         """
         Return an application menu by menu unique id.