diff --git a/airflow-core/docs/tutorial/hitl.rst b/airflow-core/docs/tutorial/hitl.rst
index aea843486f404..a1dc91da68e95 100644
--- a/airflow-core/docs/tutorial/hitl.rst
+++ b/airflow-core/docs/tutorial/hitl.rst
@@ -221,6 +221,12 @@ calls involved (``~`` works as a wildcard for ``dag_id`` and ``dag_run_id``):
     PATCH /api/v2/dags/{dag_id}/dagRuns/{dag_run_id}/taskInstances/{task_id}/{map_index}/hitlDetails
     {"chosen_options": ["Approve"], "params_input": {}}
 
+.. note::
+
+    Keys in ``params_input`` may not be Airflow's reserved serialization keys (``__classname__`` or
+    ``__id__``). A response containing one is rejected with ``400`` at submission time, because it
+    could not be serialized when the task resumes.
+
 .. note::
 
     ``response_timeout`` and timeout defaults are enforced by the scheduler, which does not run
diff --git a/airflow-core/src/airflow/api_fastapi/core_api/routes/public/hitl.py b/airflow-core/src/airflow/api_fastapi/core_api/routes/public/hitl.py
index 301a3923dea8e..204db40180a92 100644
--- a/airflow-core/src/airflow/api_fastapi/core_api/routes/public/hitl.py
+++ b/airflow-core/src/airflow/api_fastapi/core_api/routes/public/hitl.py
@@ -16,6 +16,7 @@
 # under the License.
 from __future__ import annotations
 
+from collections.abc import Mapping
 from typing import Annotated
 
 import structlog
@@ -23,6 +24,7 @@
 from sqlalchemy import select
 from sqlalchemy.orm import joinedload
 
+from airflow._shared.serialization import CLASSNAME, SCHEMA_ID
 from airflow._shared.timezones import timezone
 from airflow.api_fastapi.auth.managers.models.resource_details import DagAccessEntity
 from airflow.api_fastapi.common.db.common import SessionDep, paginated_select
@@ -80,6 +82,27 @@
 log = structlog.get_logger(__name__)
 
 
+# Keys that ``serde.serialize`` refuses at any depth. A ``params_input`` carrying one could not be
+# serialized into the resume event, so the response is rejected before it is stored. Extend this
+# tuple if serde gains another reserved key; the write-side check and its tests read from here.
+_SERDE_RESERVED_KEYS = (CLASSNAME, SCHEMA_ID)
+
+
+def _find_serde_reserved_key(value: object) -> str | None:
+    """Return the first ``_SERDE_RESERVED_KEYS`` entry found at any depth in ``value``, else ``None``."""
+    stack: list[object] = [value]
+    while stack:
+        current = stack.pop()
+        if isinstance(current, Mapping):
+            for key in _SERDE_RESERVED_KEYS:
+                if key in current:
+                    return key
+            stack.extend(current.values())
+        elif isinstance(current, (list, tuple)):
+            stack.extend(current)
+    return None
+
+
 def _get_task_instance_with_hitl_detail(
     dag_id: str,
     dag_run_id: str,
@@ -221,6 +244,13 @@ def update_hitl_detail(
             status.HTTP_400_BAD_REQUEST,
             "Multiple options chosen but this Human-in-the-loop task accepts only a single option.",
         )
+    reserved_key = _find_serde_reserved_key(update_hitl_detail_payload.params_input)
+    if reserved_key is not None:
+        raise HTTPException(
+            status.HTTP_400_BAD_REQUEST,
+            f"params_input may not contain the reserved key {reserved_key!r}, which cannot be "
+            "serialized when the task resumes.",
+        )
 
     hitl_detail_model.responded_by = hitl_user
     hitl_detail_model.responded_at = timezone.utcnow()
diff --git a/airflow-core/tests/unit/api_fastapi/core_api/routes/public/test_hitl.py b/airflow-core/tests/unit/api_fastapi/core_api/routes/public/test_hitl.py
index ad7b069581ee3..171c167225bb1 100644
--- a/airflow-core/tests/unit/api_fastapi/core_api/routes/public/test_hitl.py
+++ b/airflow-core/tests/unit/api_fastapi/core_api/routes/public/test_hitl.py
@@ -29,6 +29,7 @@
 from sqlalchemy.orm import Session
 
 from airflow._shared.timezones.timezone import utc, utcnow
+from airflow.api_fastapi.core_api.routes.public.hitl import _SERDE_RESERVED_KEYS
 from airflow.models.hitl import HITLDetail
 from airflow.models.log import Log
 from airflow.models.taskinstance import TaskInstance as TIModel
@@ -408,6 +409,75 @@ def test_should_respond_400_for_invalid_option(
         assert response.status_code == 400
         assert "Invalid options" in response.json()["detail"]
 
+    @pytest.mark.usefixtures("sample_hitl_detail")
+    @pytest.mark.parametrize("reserved_key", _SERDE_RESERVED_KEYS)
+    @pytest.mark.parametrize(
+        "make_params_input",
+        [
+            pytest.param(lambda key: {key: "x"}, id="top-level"),
+            pytest.param(lambda key: {"nested": {key: "x"}}, id="nested-dict"),
+            pytest.param(lambda key: {"items": [{key: "x"}]}, id="inside-list"),
+        ],
+    )
+    def test_should_respond_400_for_serde_reserved_key_in_params_input(
+        self,
+        test_client: TestClient,
+        sample_ti_url_identifier: str,
+        reserved_key: str,
+        make_params_input: Callable[[str], dict[str, Any]],
+    ) -> None:
+        """A params_input carrying a serde-reserved key at any depth is rejected (400) at submission time."""
+        response = test_client.patch(
+            f"{sample_ti_url_identifier}/hitlDetails",
+            json={"chosen_options": ["Approve"], "params_input": make_params_input(reserved_key)},
+        )
+        assert response.status_code == 400
+        assert reserved_key in response.json()["detail"]
+
+    @time_machine.travel(datetime(2025, 7, 3, 0, 0, 0), tick=False)
+    @pytest.mark.usefixtures("sample_hitl_detail")
+    def test_rejected_reserved_key_leaves_task_resumable(
+        self,
+        test_client: TestClient,
+        sample_ti_url_identifier: str,
+        sample_ti: TaskInstance,
+        session: Session,
+    ) -> None:
+        """A rejected reserved-key response records nothing, so the parked task is still resumable by a corrected resubmission."""
+        ti = session.get(TIModel, sample_ti.id)
+        assert ti is not None
+        ti.state = TaskInstanceState.AWAITING_INPUT
+        ti.next_method = "execute_complete"
+        ti.next_kwargs = {}
+        ti.trigger_id = None
+        session.commit()
+
+        rejected = test_client.patch(
+            f"{sample_ti_url_identifier}/hitlDetails",
+            json={"chosen_options": ["Approve"], "params_input": {_SERDE_RESERVED_KEYS[0]: "x"}},
+        )
+        assert rejected.status_code == 400
+
+        session.expire_all()
+        parked = session.get(TIModel, sample_ti.id)
+        assert parked is not None
+        assert parked.state == TaskInstanceState.AWAITING_INPUT
+        detail = session.scalar(select(HITLDetail).where(HITLDetail.ti_id == sample_ti.id))
+        assert detail is not None
+        assert detail.response_received is False
+
+        accepted = test_client.patch(
+            f"{sample_ti_url_identifier}/hitlDetails",
+            json={"chosen_options": ["Approve"], "params_input": {"input_1": 2}},
+        )
+        assert accepted.status_code == 200
+
+        session.expire_all()
+        resumed = session.get(TIModel, sample_ti.id)
+        assert resumed is not None
+        assert resumed.state == TaskInstanceState.SCHEDULED
+        assert "event" in (resumed.next_kwargs or {})
+
     @time_machine.travel(datetime(2025, 7, 3, 0, 0, 0), tick=False)
     @pytest.mark.usefixtures("sample_hitl_detail_respondent")
     def test_should_respond_200_to_assigned_users(