diff --git a/boards/sim/sim/sim/configs/ostest/defconfig b/boards/sim/sim/sim/configs/ostest/defconfig
index 37312520c3f75..8b2959cb55ec2 100644
--- a/boards/sim/sim/sim/configs/ostest/defconfig
+++ b/boards/sim/sim/sim/configs/ostest/defconfig
@@ -14,10 +14,15 @@ CONFIG_BOARDCTL=y
 CONFIG_BOARDCTL_POWEROFF=y
 CONFIG_BOARD_LOOPSPERMSEC=100
 CONFIG_CANCELLATION_POINTS=y
+CONFIG_DEBUG_ASSERTIONS=y
+CONFIG_DEBUG_FEATURES=y
 CONFIG_DEBUG_SYMBOLS=y
 CONFIG_FS_NAMED_SEMAPHORES=y
 CONFIG_IDLETHREAD_STACKSIZE=4096
 CONFIG_INIT_ENTRYPOINT="ostest_main"
+CONFIG_MM_KASAN=y
+CONFIG_MM_UBSAN=y
+CONFIG_MM_UBSAN_TRAP_ON_ERROR=y
 CONFIG_PTHREAD_CLEANUP=y
 CONFIG_PTHREAD_CLEANUP_STACKSIZE=3
 CONFIG_PTHREAD_MUTEX_TYPES=y
diff --git a/tools/ci/testlist/sim-02.dat b/tools/ci/testlist/sim-02.dat
index 28b3e693fd052..c47ec022f9ec6 100644
--- a/tools/ci/testlist/sim-02.dat
+++ b/tools/ci/testlist/sim-02.dat
@@ -6,6 +6,9 @@
 -Darwin,sim:rpserver
 -Darwin,sim:sotest32
 
+# clang doesn't -fsanitize=kernel-address
+-Darwin,sim:ostest
+
 # macOS doesn't support --wrap flag
 # ld: unknown option: --wrap
 -Darwin,sim:segger