diff --git a/superset/db_engine_specs/athena.py b/superset/db_engine_specs/athena.py
index d82591756a00..2952d8267772 100644
--- a/superset/db_engine_specs/athena.py
+++ b/superset/db_engine_specs/athena.py
@@ -14,12 +14,20 @@
 # KIND, either express or implied.  See the License for the
 # specific language governing permissions and limitations
 # under the License.
+import re
 from datetime import datetime
-from typing import Optional
+from typing import Any, Dict, Optional, Pattern, Tuple
+
+from flask_babel import gettext as __
 
 from superset.db_engine_specs.base import BaseEngineSpec
+from superset.errors import SupersetErrorType
 from superset.utils import core as utils
 
+SYNTAX_ERROR_REGEX = re.compile(
+    ": mismatched input '(?P<syntax_error>.*?)'. Expecting: "
+)
+
 
 class AthenaEngineSpec(BaseEngineSpec):
     engine = "awsathena"
@@ -41,6 +49,17 @@ class AthenaEngineSpec(BaseEngineSpec):
                                     date_add('day', 1, CAST({col} AS TIMESTAMP))))",
     }
 
+    custom_errors: Dict[Pattern[str], Tuple[str, SupersetErrorType, Dict[str, Any]]] = {
+        SYNTAX_ERROR_REGEX: (
+            __(
+                "Please check your query for syntax errors at or "
+                'near "%(syntax_error)s". Then, try running your query again.'
+            ),
+            SupersetErrorType.SYNTAX_ERROR,
+            {},
+        ),
+    }
+
     @classmethod
     def convert_dttm(cls, target_type: str, dttm: datetime) -> Optional[str]:
         tt = target_type.upper()
diff --git a/superset/db_engine_specs/gsheets.py b/superset/db_engine_specs/gsheets.py
index f715cd43b332..1773a3db5cce 100644
--- a/superset/db_engine_specs/gsheets.py
+++ b/superset/db_engine_specs/gsheets.py
@@ -14,12 +14,17 @@
 # KIND, either express or implied.  See the License for the
 # specific language governing permissions and limitations
 # under the License.
-from typing import Optional
+import re
+from typing import Any, Dict, Optional, Pattern, Tuple
 
+from flask_babel import gettext as __
 from sqlalchemy.engine.url import URL
 
 from superset import security_manager
 from superset.db_engine_specs.sqlite import SqliteEngineSpec
+from superset.errors import SupersetErrorType
+
+SYNTAX_ERROR_REGEX = re.compile('SQLError: near "(?P<server_error>.*?)": syntax error')
 
 
 class GSheetsEngineSpec(SqliteEngineSpec):
@@ -30,6 +35,17 @@ class GSheetsEngineSpec(SqliteEngineSpec):
     allows_joins = False
     allows_subqueries = True
 
+    custom_errors: Dict[Pattern[str], Tuple[str, SupersetErrorType, Dict[str, Any]]] = {
+        SYNTAX_ERROR_REGEX: (
+            __(
+                'Please check your query for syntax errors near "%(server_error)s". '
+                "Then, try running your query again."
+            ),
+            SupersetErrorType.SYNTAX_ERROR,
+            {},
+        ),
+    }
+
     @classmethod
     def modify_url_for_impersonation(
         cls, url: URL, impersonate_user: bool, username: Optional[str]
diff --git a/superset/db_engine_specs/mysql.py b/superset/db_engine_specs/mysql.py
index 4bb5979706b5..01be0c6e13d0 100644
--- a/superset/db_engine_specs/mysql.py
+++ b/superset/db_engine_specs/mysql.py
@@ -52,6 +52,11 @@
 )
 CONNECTION_UNKNOWN_DATABASE_REGEX = re.compile("Unknown database '(?P<database>.*?)'")
 
+SYNTAX_ERROR_REGEX = re.compile(
+    "check the manual that corresponds to your MySQL server "
+    "version for the right syntax to use near '(?P<server_error>.*)"
+)
+
 
 class MySQLEngineSpec(BaseEngineSpec, BasicParametersMixin):
     engine = "mysql"
@@ -134,6 +139,14 @@ class MySQLEngineSpec(BaseEngineSpec, BasicParametersMixin):
             SupersetErrorType.CONNECTION_UNKNOWN_DATABASE_ERROR,
             {"invalid": ["database"]},
         ),
+        SYNTAX_ERROR_REGEX: (
+            __(
+                'Please check your query for syntax errors near "%(server_error)s". '
+                "Then, try running your query again."
+            ),
+            SupersetErrorType.SYNTAX_ERROR,
+            {},
+        ),
     }
 
     @classmethod
diff --git a/superset/db_engine_specs/postgres.py b/superset/db_engine_specs/postgres.py
index 03c955a67d81..ee95d5dd3d50 100644
--- a/superset/db_engine_specs/postgres.py
+++ b/superset/db_engine_specs/postgres.py
@@ -85,6 +85,8 @@ class FixedOffsetTimezone(_FixedOffset):
     r"does not exist\s+LINE (?P<location>\d+?)"
 )
 
+SYNTAX_ERROR_REGEX = re.compile('syntax error at or near "(?P<syntax_error>.*?)"')
+
 
 class PostgresBaseEngineSpec(BaseEngineSpec):
     """ Abstract class for Postgres 'like' databases """
@@ -151,6 +153,14 @@ class PostgresBaseEngineSpec(BaseEngineSpec):
             SupersetErrorType.COLUMN_DOES_NOT_EXIST_ERROR,
             {},
         ),
+        SYNTAX_ERROR_REGEX: (
+            __(
+                "Please check your query for syntax errors at or "
+                'near "%(syntax_error)s". Then, try running your query again.'
+            ),
+            SupersetErrorType.SYNTAX_ERROR,
+            {},
+        ),
     }
 
     @classmethod
diff --git a/tests/db_engine_specs/athena_tests.py b/tests/db_engine_specs/athena_tests.py
index d928a986daf3..bb53d8ee0347 100644
--- a/tests/db_engine_specs/athena_tests.py
+++ b/tests/db_engine_specs/athena_tests.py
@@ -15,6 +15,7 @@
 # specific language governing permissions and limitations
 # under the License.
 from superset.db_engine_specs.athena import AthenaEngineSpec
+from superset.errors import ErrorLevel, SupersetError, SupersetErrorType
 from tests.db_engine_specs.base_tests import TestDbEngineSpec
 
 
@@ -31,3 +32,26 @@ def test_convert_dttm(self):
             AthenaEngineSpec.convert_dttm("TIMESTAMP", dttm),
             "from_iso8601_timestamp('2019-01-02T03:04:05.678900')",
         )
+
+    def test_extract_errors(self):
+        """
+        Test that custom error messages are extracted correctly.
+        """
+        msg = ": mismatched input 'fromm'. Expecting: "
+        result = AthenaEngineSpec.extract_errors(Exception(msg))
+        assert result == [
+            SupersetError(
+                message='Please check your query for syntax errors at or near "fromm". Then, try running your query again.',
+                error_type=SupersetErrorType.SYNTAX_ERROR,
+                level=ErrorLevel.ERROR,
+                extra={
+                    "engine_name": "Amazon Athena",
+                    "issue_codes": [
+                        {
+                            "code": 1030,
+                            "message": "Issue 1030 - The query has a syntax error.",
+                        }
+                    ],
+                },
+            )
+        ]
diff --git a/tests/db_engine_specs/gsheets_tests.py b/tests/db_engine_specs/gsheets_tests.py
new file mode 100644
index 000000000000..e9a021d8dca9
--- /dev/null
+++ b/tests/db_engine_specs/gsheets_tests.py
@@ -0,0 +1,44 @@
+# Licensed to the Apache Software Foundation (ASF) under one
+# or more contributor license agreements.  See the NOTICE file
+# distributed with this work for additional information
+# regarding copyright ownership.  The ASF licenses this file
+# to you under the Apache License, Version 2.0 (the
+# "License"); you may not use this file except in compliance
+# with the License.  You may obtain a copy of the License at
+#
+#   http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing,
+# software distributed under the License is distributed on an
+# "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+# KIND, either express or implied.  See the License for the
+# specific language governing permissions and limitations
+# under the License.
+from superset.db_engine_specs.gsheets import GSheetsEngineSpec
+from superset.errors import ErrorLevel, SupersetError, SupersetErrorType
+from tests.db_engine_specs.base_tests import TestDbEngineSpec
+
+
+class TestGsheetsDbEngineSpec(TestDbEngineSpec):
+    def test_extract_errors(self):
+        """
+        Test that custom error messages are extracted correctly.
+        """
+        msg = 'SQLError: near "fromm": syntax error'
+        result = GSheetsEngineSpec.extract_errors(Exception(msg))
+        assert result == [
+            SupersetError(
+                message='Please check your query for syntax errors near "fromm". Then, try running your query again.',
+                error_type=SupersetErrorType.SYNTAX_ERROR,
+                level=ErrorLevel.ERROR,
+                extra={
+                    "engine_name": "Google Sheets",
+                    "issue_codes": [
+                        {
+                            "code": 1030,
+                            "message": "Issue 1030 - The query has a syntax error.",
+                        }
+                    ],
+                },
+            )
+        ]
diff --git a/tests/db_engine_specs/mysql_tests.py b/tests/db_engine_specs/mysql_tests.py
index aa23f2935f58..7f0755ac1308 100644
--- a/tests/db_engine_specs/mysql_tests.py
+++ b/tests/db_engine_specs/mysql_tests.py
@@ -199,7 +199,6 @@ def test_extract_errors(self):
 
         msg = "mysql: Unknown database 'badDB'"
         result = MySQLEngineSpec.extract_errors(Exception(msg))
-        print(result)
         assert result == [
             SupersetError(
                 message='Unable to connect to database "badDB".',
@@ -217,3 +216,22 @@ def test_extract_errors(self):
                 },
             )
         ]
+
+        msg = "check the manual that corresponds to your MySQL server version for the right syntax to use near 'fromm"
+        result = MySQLEngineSpec.extract_errors(Exception(msg))
+        assert result == [
+            SupersetError(
+                message='Please check your query for syntax errors near "fromm". Then, try running your query again.',
+                error_type=SupersetErrorType.SYNTAX_ERROR,
+                level=ErrorLevel.ERROR,
+                extra={
+                    "engine_name": "MySQL",
+                    "issue_codes": [
+                        {
+                            "code": 1030,
+                            "message": "Issue 1030 - The query has a syntax error.",
+                        }
+                    ],
+                },
+            )
+        ]
diff --git a/tests/db_engine_specs/postgres_tests.py b/tests/db_engine_specs/postgres_tests.py
index 135621b5e5c9..7f999f07dbd4 100644
--- a/tests/db_engine_specs/postgres_tests.py
+++ b/tests/db_engine_specs/postgres_tests.py
@@ -421,6 +421,25 @@ def test_extract_errors(self):
             )
         ]
 
+        msg = 'syntax error at or near "fromm"'
+        result = PostgresEngineSpec.extract_errors(Exception(msg))
+        assert result == [
+            SupersetError(
+                message='Please check your query for syntax errors at or near "fromm". Then, try running your query again.',
+                error_type=SupersetErrorType.SYNTAX_ERROR,
+                level=ErrorLevel.ERROR,
+                extra={
+                    "engine_name": "PostgreSQL",
+                    "issue_codes": [
+                        {
+                            "code": 1030,
+                            "message": "Issue 1030 - The query has a syntax error.",
+                        }
+                    ],
+                },
+            )
+        ]
+
 
 def test_base_parameters_mixin():
     parameters = {