diff --git a/pyproject.toml b/pyproject.toml
index 2e1468db60e7..3ee5116fb55f 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -50,7 +50,7 @@ dependencies = [
     "flask-cors>=6.0.5, <7.0",
     "croniter>=6.2.4",
     "cron-descriptor",
-    "cryptography>=49.0.0, <50.0.0",
+    "cryptography>=50.0.0, <51.0.0",
     "deprecation>=2.1.0, <2.2.0",
     "flask>=2.2.5, <4.0.0",
     "flask-appbuilder>=5.2.2, <6.0.0",
diff --git a/requirements/base.in b/requirements/base.in
index 946592c8ed65..386889914212 100644
--- a/requirements/base.in
+++ b/requirements/base.in
@@ -26,7 +26,7 @@ filelock>=3.20.3,<4.0.0
 brotli>=1.2.0,<2.0.0
 numexpr>=2.9.0
 # Security: CVE-2026-34073 (MEDIUM) - Improper Certificate Validation
-cryptography>=49.0.0,<50.0.0
+cryptography>=50.0.0,<51.0.0
 # Security: Snyk - XSS vulnerability in Mako templates
 mako>=1.3.11,<2.0.0
 # Security: CVE-2024-52338 (CRITICAL) - Deserialization of untrusted data in IPC/Parquet readers
diff --git a/requirements/base.txt b/requirements/base.txt
index f44ed45930ac..4a97eb8b266c 100644
--- a/requirements/base.txt
+++ b/requirements/base.txt
@@ -88,7 +88,7 @@ cron-descriptor==1.4.5
     # via apache-superset (pyproject.toml)
 croniter==6.2.4
     # via apache-superset (pyproject.toml)
-cryptography==49.0.0
+cryptography==50.0.0
     # via
     #   -r requirements/base.in
     #   apache-superset (pyproject.toml)
@@ -326,7 +326,7 @@ pyjwt==2.13.0
     #   flask-jwt-extended
 pynacl==1.6.2
     # via paramiko
-pyopenssl==26.3.0
+pyopenssl==26.4.0
     # via
     #   -r requirements/base.in
     #   shillelagh
diff --git a/requirements/development.txt b/requirements/development.txt
index ec05bdcdca87..02d31047c6d5 100644
--- a/requirements/development.txt
+++ b/requirements/development.txt
@@ -182,7 +182,7 @@ croniter==6.2.4
     # via
     #   -c requirements/base-constraint.txt
     #   apache-superset
-cryptography==49.0.0
+cryptography==50.0.0
     # via
     #   -c requirements/base-constraint.txt
     #   apache-superset
@@ -791,7 +791,7 @@ pynacl==1.6.2
     # via
     #   -c requirements/base-constraint.txt
     #   paramiko
-pyopenssl==26.3.0
+pyopenssl==26.4.0
     # via
     #   -c requirements/base-constraint.txt
     #   google-auth