diff --git a/.changeset/flat-singers-kiss.md b/.changeset/flat-singers-kiss.md
new file mode 100644
index 00000000000..74727e85370
--- /dev/null
+++ b/.changeset/flat-singers-kiss.md
@@ -0,0 +1,5 @@
+---
+"@apollo/client": patch
+---
+
+Fix issue where passing a new `from` option to `useFragment` would first render with the previous value before rerendering with the correct value.
diff --git a/.size-limits.json b/.size-limits.json
index fc5f57b1041..6ea6a4c6ebc 100644
--- a/.size-limits.json
+++ b/.size-limits.json
@@ -1,4 +1,4 @@
 {
-  "dist/apollo-client.min.cjs": 39248,
+  "dist/apollo-client.min.cjs": 39267,
   "import { ApolloClient, InMemoryCache, HttpLink } from \"dist/index.js\" (production)": 32630
 }
diff --git a/src/react/hooks/__tests__/useFragment.test.tsx b/src/react/hooks/__tests__/useFragment.test.tsx
index 27f4857edd6..d5436bc5097 100644
--- a/src/react/hooks/__tests__/useFragment.test.tsx
+++ b/src/react/hooks/__tests__/useFragment.test.tsx
@@ -29,7 +29,7 @@ import { concatPagination } from "../../../utilities";
 import assert from "assert";
 import { expectTypeOf } from "expect-type";
 import { SubscriptionObserver } from "zen-observable-ts";
-import { profile, spyOnConsole } from "../../../testing/internal";
+import { profile, profileHook, spyOnConsole } from "../../../testing/internal";
 
 describe("useFragment", () => {
   it("is importable and callable", () => {
@@ -1359,6 +1359,61 @@ describe("useFragment", () => {
     });
   });
 
+  it("returns correct data when options change", async () => {
+    const client = new ApolloClient({
+      cache: new InMemoryCache(),
+    });
+    type User = { __typename: "User"; id: number; name: string };
+    const fragment: TypedDocumentNode<User> = gql`
+      fragment UserFragment on User {
+        id
+        name
+      }
+    `;
+
+    client.writeFragment({
+      fragment,
+      data: { __typename: "User", id: 1, name: "Alice" },
+    });
+
+    client.writeFragment({
+      fragment,
+      data: { __typename: "User", id: 2, name: "Charlie" },
+    });
+
+    const ProfiledHook = profileHook(({ id }: { id: number }) =>
+      useFragment({ fragment, from: { __typename: "User", id } })
+    );
+
+    const { rerender } = render(<ProfiledHook id={1} />, {
+      wrapper: ({ children }) => (
+        <ApolloProvider client={client}>{children}</ApolloProvider>
+      ),
+    });
+
+    {
+      const snapshot = await ProfiledHook.takeSnapshot();
+
+      expect(snapshot).toEqual({
+        complete: true,
+        data: { __typename: "User", id: 1, name: "Alice" },
+      });
+    }
+
+    rerender(<ProfiledHook id={2} />);
+
+    {
+      const snapshot = await ProfiledHook.takeSnapshot();
+
+      expect(snapshot).toEqual({
+        complete: true,
+        data: { __typename: "User", id: 2, name: "Charlie" },
+      });
+    }
+
+    await expect(ProfiledHook).not.toRerender();
+  });
+
   describe("tests with incomplete data", () => {
     let cache: InMemoryCache, wrapper: React.FunctionComponent;
     const ItemFragment = gql`
diff --git a/src/react/hooks/useFragment.ts b/src/react/hooks/useFragment.ts
index 9e5381c7480..368e6273d85 100644
--- a/src/react/hooks/useFragment.ts
+++ b/src/react/hooks/useFragment.ts
@@ -88,6 +88,12 @@ function _useFragment<TData = any, TVars = OperationVariables>(
     diffToResult(cache.diff<TData>(diffOptions))
   );
 
+  // Since .next is async, we need to make sure that we
+  // get the correct diff on the next render given new diffOptions
+  React.useMemo(() => {
+    resultRef.current = diffToResult(cache.diff<TData>(diffOptions));
+  }, [diffOptions, cache]);
+
   // Used for both getSnapshot and getServerSnapshot
   const getSnapshot = React.useCallback(() => resultRef.current, []);