diff --git a/package-lock.json b/package-lock.json
index 1f81959bc88..accf7978136 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -1290,6 +1290,22 @@
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           "version": "1.0.2",
           "resolved": "https://registry.npmjs.org/is-descriptor/-/is-descriptor-1.0.2.tgz",
           "integrity": "sha512-2eis5WqQGV7peooDyLmNEPUrps9+SXX5c9pL3xEB+4e9HnGuDa7mB7kHxHw4CbqS9k1T2hOH3miL8n8WtiYVtg==",
-          "dev": true,
           "requires": {
             "is-accessor-descriptor": "^1.0.0",
             "is-data-descriptor": "^1.0.0",
@@ -9816,7 +9950,6 @@
       "version": "3.0.1",
       "resolved": "https://registry.npmjs.org/snapdragon-util/-/snapdragon-util-3.0.1.tgz",
       "integrity": "sha512-mbKkMdQKsjX4BAL4bRYTj21edOf8cN7XHdYUJEe+Zn99hVEYcMvKPct1IqNe7+AZPirn8BCDOQBHQZknqmKlZQ==",
-      "dev": true,
       "requires": {
         "kind-of": "^3.2.0"
       },
@@ -9824,14 +9957,12 @@
         "is-buffer": {
           "version": "1.1.6",
           "resolved": "https://registry.npmjs.org/is-buffer/-/is-buffer-1.1.6.tgz",
-          "integrity": "sha512-NcdALwpXkTm5Zvvbk7owOUSvVvBKDgKP5/ewfXEznmQFfs4ZRmanOeKBTjRVjka3QFoN6XJ+9F3USqfHqTaU5w==",
-          "dev": true
+          "integrity": "sha512-NcdALwpXkTm5Zvvbk7owOUSvVvBKDgKP5/ewfXEznmQFfs4ZRmanOeKBTjRVjka3QFoN6XJ+9F3USqfHqTaU5w=="
         },
         "kind-of": {
           "version": "3.2.2",
           "resolved": "https://registry.npmjs.org/kind-of/-/kind-of-3.2.2.tgz",
           "integrity": "sha1-MeohpzS6ubuw8yRm2JOupR5KPGQ=",
-          "dev": true,
           "requires": {
             "is-buffer": "^1.1.5"
           }
@@ -9848,7 +9979,6 @@
       "version": "0.5.3",
       "resolved": "https://registry.npmjs.org/source-map-resolve/-/source-map-resolve-0.5.3.tgz",
       "integrity": "sha512-Htz+RnsXWk5+P2slx5Jh3Q66vhQj1Cllm0zvnaY98+NFx+Dv2CF/f5O/t8x+KaNdrdIAsruNzoh/KpialbqAnw==",
-      "dev": true,
       "requires": {
         "atob": "^2.1.2",
         "decode-uri-component": "^0.2.0",
@@ -9870,8 +10000,7 @@
     "source-map-url": {
       "version": "0.4.0",
       "resolved": "https://registry.npmjs.org/source-map-url/-/source-map-url-0.4.0.tgz",
-      "integrity": "sha1-PpNdfd1zYxuXZZlW1VEo6HtQhKM=",
-      "dev": true
+      "integrity": "sha1-PpNdfd1zYxuXZZlW1VEo6HtQhKM="
     },
     "spdx-correct": {
       "version": "3.1.1",
@@ -9918,7 +10047,6 @@
       "version": "3.1.0",
       "resolved": "https://registry.npmjs.org/split-string/-/split-string-3.1.0.tgz",
       "integrity": "sha512-NzNVhJDYpwceVVii8/Hu6DKfD2G+NrQHlS/V/qgv763EYudVwEcMQNxd2lh+0VrUByXN/oJkl5grOhYWvQUYiw==",
-      "dev": true,
       "requires": {
         "extend-shallow": "^3.0.0"
       }
@@ -9967,7 +10095,6 @@
       "version": "0.1.2",
       "resolved": "https://registry.npmjs.org/static-extend/-/static-extend-0.1.2.tgz",
       "integrity": "sha1-YICcOcv/VTNyJv1eC1IPNB8ftcY=",
-      "dev": true,
       "requires": {
         "define-property": "^0.2.5",
         "object-copy": "^0.1.0"
@@ -9977,7 +10104,6 @@
           "version": "0.2.5",
           "resolved": "https://registry.npmjs.org/define-property/-/define-property-0.2.5.tgz",
           "integrity": "sha1-w1se+RjsPJkPmlvFe+BKrOxcgRY=",
-          "dev": true,
           "requires": {
             "is-descriptor": "^0.1.0"
           }
@@ -10229,6 +10355,14 @@
       "integrity": "sha1-DdTJ/6q8NXlgsbckEV1+Doai4fU=",
       "dev": true
     },
+    "tmp": {
+      "version": "0.0.33",
+      "resolved": "https://registry.npmjs.org/tmp/-/tmp-0.0.33.tgz",
+      "integrity": "sha512-jRCJlojKnZ3addtTOjdIqoRuPEKBvNXcGYqzO6zWZX8KfKEpnGY5jfggJQ3EjKuu8D4bJRr0y+cYJFmYbImXGw==",
+      "requires": {
+        "os-tmpdir": "~1.0.2"
+      }
+    },
     "tmpl": {
       "version": "1.0.4",
       "resolved": "https://registry.npmjs.org/tmpl/-/tmpl-1.0.4.tgz",
@@ -10245,7 +10379,6 @@
       "version": "0.3.0",
       "resolved": "https://registry.npmjs.org/to-object-path/-/to-object-path-0.3.0.tgz",
       "integrity": "sha1-KXWIt7Dn4KwI4E5nL4XB9JmeF68=",
-      "dev": true,
       "requires": {
         "kind-of": "^3.0.2"
       },
@@ -10253,14 +10386,12 @@
         "is-buffer": {
           "version": "1.1.6",
           "resolved": "https://registry.npmjs.org/is-buffer/-/is-buffer-1.1.6.tgz",
-          "integrity": "sha512-NcdALwpXkTm5Zvvbk7owOUSvVvBKDgKP5/ewfXEznmQFfs4ZRmanOeKBTjRVjka3QFoN6XJ+9F3USqfHqTaU5w==",
-          "dev": true
+          "integrity": "sha512-NcdALwpXkTm5Zvvbk7owOUSvVvBKDgKP5/ewfXEznmQFfs4ZRmanOeKBTjRVjka3QFoN6XJ+9F3USqfHqTaU5w=="
         },
         "kind-of": {
           "version": "3.2.2",
           "resolved": "https://registry.npmjs.org/kind-of/-/kind-of-3.2.2.tgz",
           "integrity": "sha1-MeohpzS6ubuw8yRm2JOupR5KPGQ=",
-          "dev": true,
           "requires": {
             "is-buffer": "^1.1.5"
           }
@@ -10271,7 +10402,6 @@
       "version": "3.0.2",
       "resolved": "https://registry.npmjs.org/to-regex/-/to-regex-3.0.2.tgz",
       "integrity": "sha512-FWtleNAtZ/Ki2qtqej2CXTOayOH9bHDQF+Q48VpWyDXjbYxA4Yz8iDB31zXOBUlOHHKidDbqGVrTUvQMPmBGBw==",
-      "dev": true,
       "requires": {
         "define-property": "^2.0.2",
         "extend-shallow": "^3.0.2",
@@ -10486,7 +10616,6 @@
       "version": "1.0.1",
       "resolved": "https://registry.npmjs.org/union-value/-/union-value-1.0.1.tgz",
       "integrity": "sha512-tJfXmxMeWYnczCVs7XAEvIV7ieppALdyepWMkHkwciRpZraG/xwT+s2JN8+pr1+8jCRf80FFzvr+MpQeeoF4Xg==",
-      "dev": true,
       "requires": {
         "arr-union": "^3.1.0",
         "get-value": "^2.0.6",
@@ -10524,7 +10653,6 @@
       "version": "1.0.0",
       "resolved": "https://registry.npmjs.org/unset-value/-/unset-value-1.0.0.tgz",
       "integrity": "sha1-g3aHP30jNRef+x5vw6jtDfyKtVk=",
-      "dev": true,
       "requires": {
         "has-value": "^0.3.1",
         "isobject": "^3.0.0"
@@ -10534,7 +10662,6 @@
           "version": "0.3.1",
           "resolved": "https://registry.npmjs.org/has-value/-/has-value-0.3.1.tgz",
           "integrity": "sha1-ex9YutpiyoJ+wKIHgCVlSEWZXh8=",
-          "dev": true,
           "requires": {
             "get-value": "^2.0.3",
             "has-values": "^0.1.4",
@@ -10545,7 +10672,6 @@
               "version": "2.1.0",
               "resolved": "https://registry.npmjs.org/isobject/-/isobject-2.1.0.tgz",
               "integrity": "sha1-8GVWEJaj8dou9GJy+BXIQNh+DIk=",
-              "dev": true,
               "requires": {
                 "isarray": "1.0.0"
               }
@@ -10555,8 +10681,7 @@
         "has-values": {
           "version": "0.1.4",
           "resolved": "https://registry.npmjs.org/has-values/-/has-values-0.1.4.tgz",
-          "integrity": "sha1-bWHeldkd/Km5oCCJrThL/49it3E=",
-          "dev": true
+          "integrity": "sha1-bWHeldkd/Km5oCCJrThL/49it3E="
         }
       }
     },
@@ -10572,14 +10697,12 @@
     "urix": {
       "version": "0.1.0",
       "resolved": "https://registry.npmjs.org/urix/-/urix-0.1.0.tgz",
-      "integrity": "sha1-2pN/emLiH+wf0Y1Js1wpNQZ6bHI=",
-      "dev": true
+      "integrity": "sha1-2pN/emLiH+wf0Y1Js1wpNQZ6bHI="
     },
     "use": {
       "version": "3.1.1",
       "resolved": "https://registry.npmjs.org/use/-/use-3.1.1.tgz",
-      "integrity": "sha512-cwESVXlO3url9YWlFW/TA9cshCEhtu7IKJ/p5soJ/gGpj7vbvFrAY/eIioQ6Dw23KjZhYgiIo8HOs1nQ2vr/oQ==",
-      "dev": true
+      "integrity": "sha512-cwESVXlO3url9YWlFW/TA9cshCEhtu7IKJ/p5soJ/gGpj7vbvFrAY/eIioQ6Dw23KjZhYgiIo8HOs1nQ2vr/oQ=="
     },
     "util-deprecate": {
       "version": "1.0.2",
@@ -10759,7 +10882,6 @@
       "version": "1.3.1",
       "resolved": "https://registry.npmjs.org/which/-/which-1.3.1.tgz",
       "integrity": "sha512-HxJdYWq1MTIQbJ3nw0cqssHoTNU267KlrDuGZ1WYlxDStUtKUhOaJmh112/TZmHxxUfuJqPXSOm7tDyas0OSIQ==",
-      "dev": true,
       "requires": {
         "isexe": "^2.0.0"
       }
@@ -10864,8 +10986,7 @@
     "wrappy": {
       "version": "1.0.2",
       "resolved": "https://registry.npmjs.org/wrappy/-/wrappy-1.0.2.tgz",
-      "integrity": "sha1-tSQ9jz7BqjXxNkYFvA0QNuMKtp8=",
-      "dev": true
+      "integrity": "sha1-tSQ9jz7BqjXxNkYFvA0QNuMKtp8="
     },
     "write-file-atomic": {
       "version": "3.0.3",
diff --git a/package.json b/package.json
index f6e18a8bd65..d6848089b9c 100644
--- a/package.json
+++ b/package.json
@@ -67,6 +67,7 @@
     }
   },
   "dependencies": {
+    "@graphql-typed-document-node/core": "^2.1.0",
     "@types/zen-observable": "^0.8.0",
     "@wry/context": "^0.5.2",
     "@wry/equality": "^0.2.0",
diff --git a/src/__tests__/ApolloClient.ts b/src/__tests__/ApolloClient.ts
index d73d0a31c0b..2f8a1870f18 100644
--- a/src/__tests__/ApolloClient.ts
+++ b/src/__tests__/ApolloClient.ts
@@ -13,6 +13,7 @@ import { ApolloLink } from '../link/core';
 import { HttpLink } from '../link/http';
 import { InMemoryCache } from '../cache';
 import { stripSymbols } from '../testing';
+import { TypedDocumentNode } from '@graphql-typed-document-node/core';
 
 describe('ApolloClient', () => {
   describe('constructor', () => {
@@ -1210,6 +1211,22 @@ describe('ApolloClient', () => {
       }
 
       describe('using writeQuery', () => {
+        it('with TypedDocumentNode', async () => {
+          const client = newClient();
+
+          // This is defined manually for the purpose of the test, but
+          // eventually this could be generated with graphql-code-generator
+          const typedQuery: TypedDocumentNode<Data, { testVar: string }> = query;
+
+          // The result and variables are being typed automatically, based on the query object we pass,
+          // and type inference is done based on the TypeDocumentNode object.
+          const result = await client.query({ query: typedQuery, variables: { testVar: 'foo' } });
+
+          // Just try to access it, if something will break, TS will throw an error
+          // during the test
+          result.data?.people.friends[0].id;
+        });
+
         it('with a replacement of nested array (wq)', done => {
           let count = 0;
           const client = newClient();
diff --git a/src/cache/core/cache.ts b/src/cache/core/cache.ts
index 6babc4aeb58..19eb8dd6127 100644
--- a/src/cache/core/cache.ts
+++ b/src/cache/core/cache.ts
@@ -15,7 +15,7 @@ export abstract class ApolloCache<TSerialized> implements DataProxy {
   // required to implement
   // core API
   public abstract read<T, TVariables = any>(
-    query: Cache.ReadOptions<TVariables>,
+    query: Cache.ReadOptions<TVariables, T>,
   ): T | null;
   public abstract write<TResult = any, TVariables = any>(
     write: Cache.WriteOptions<TResult, TVariables>,
@@ -104,7 +104,7 @@ export abstract class ApolloCache<TSerialized> implements DataProxy {
    * @param optimistic
    */
   public readQuery<QueryType, TVariables = any>(
-    options: DataProxy.Query<TVariables>,
+    options: DataProxy.Query<TVariables, QueryType>,
     optimistic: boolean = false,
   ): QueryType | null {
     return this.read({
@@ -120,7 +120,7 @@ export abstract class ApolloCache<TSerialized> implements DataProxy {
   private getFragmentDoc = wrap(getFragmentQueryDocument);
 
   public readFragment<FragmentType, TVariables = any>(
-    options: DataProxy.Fragment<TVariables>,
+    options: DataProxy.Fragment<TVariables, FragmentType>,
     optimistic: boolean = false,
   ): FragmentType | null {
     return this.read({
diff --git a/src/cache/core/types/Cache.ts b/src/cache/core/types/Cache.ts
index 21c2535538e..8a9af7c3ff1 100644
--- a/src/cache/core/types/Cache.ts
+++ b/src/cache/core/types/Cache.ts
@@ -4,15 +4,15 @@ import { Modifier, Modifiers } from './common';
 export namespace Cache {
   export type WatchCallback = (diff: Cache.DiffResult<any>) => void;
 
-  export interface ReadOptions<TVariables = any>
-    extends DataProxy.Query<TVariables> {
+  export interface ReadOptions<TVariables = any, TData = any>
+    extends DataProxy.Query<TVariables, TData> {
     rootId?: string;
     previousResult?: any;
     optimistic: boolean;
   }
 
   export interface WriteOptions<TResult = any, TVariables = any>
-    extends DataProxy.Query<TVariables> {
+    extends DataProxy.Query<TVariables, TResult> {
     dataId?: string;
     result: TResult;
     broadcast?: boolean;
diff --git a/src/cache/core/types/DataProxy.ts b/src/cache/core/types/DataProxy.ts
index 2e02ae6c42e..0b7d66bbe70 100644
--- a/src/cache/core/types/DataProxy.ts
+++ b/src/cache/core/types/DataProxy.ts
@@ -1,15 +1,16 @@
 import { DocumentNode } from 'graphql'; // eslint-disable-line import/no-extraneous-dependencies, import/no-unresolved
+import { TypedDocumentNode } from '@graphql-typed-document-node/core';
 
 import { MissingFieldError } from './common';
 
 export namespace DataProxy {
-  export interface Query<TVariables> {
+  export interface Query<TVariables, TData> {
     /**
      * The GraphQL query shape to be used constructed using the `gql` template
      * string tag from `graphql-tag`. The query will be used to determine the
      * shape of the data to be read.
      */
-    query: DocumentNode;
+    query: DocumentNode | TypedDocumentNode<TData, TVariables>;
 
     /**
      * Any variables that the GraphQL query may depend on.
@@ -24,7 +25,7 @@ export namespace DataProxy {
     id?: string;
   }
 
-  export interface Fragment<TVariables> {
+  export interface Fragment<TVariables, TData> {
     /**
      * The root id to be used. This id should take the same form as the
      * value returned by your `dataIdFromObject` function. If a value with your
@@ -38,7 +39,7 @@ export namespace DataProxy {
      * the shape of data to read. If you provide more than one fragment in this
      * document then you must also specify `fragmentName` to select a single.
      */
-    fragment: DocumentNode;
+    fragment: DocumentNode | TypedDocumentNode<TData, TVariables>;
 
     /**
      * The name of the fragment in your GraphQL document to be used. If you do
@@ -54,7 +55,7 @@ export namespace DataProxy {
   }
 
   export interface WriteQueryOptions<TData, TVariables>
-    extends Query<TVariables> {
+    extends Query<TVariables, TData> {
     /**
      * The data you will be writing to the store.
      */
@@ -66,7 +67,7 @@ export namespace DataProxy {
   }
 
   export interface WriteFragmentOptions<TData, TVariables>
-    extends Fragment<TVariables> {
+    extends Fragment<TVariables, TData> {
     /**
      * The data you will be writing to the store.
      */
@@ -95,7 +96,7 @@ export interface DataProxy {
    * Reads a GraphQL query from the root query id.
    */
   readQuery<QueryType, TVariables = any>(
-    options: DataProxy.Query<TVariables>,
+    options: DataProxy.Query<TVariables, QueryType>,
     optimistic?: boolean,
   ): QueryType | null;
 
@@ -105,7 +106,7 @@ export interface DataProxy {
    * provided to select the correct fragment.
    */
   readFragment<FragmentType, TVariables = any>(
-    options: DataProxy.Fragment<TVariables>,
+    options: DataProxy.Fragment<TVariables, FragmentType>,
     optimistic?: boolean,
   ): FragmentType | null;
 
diff --git a/src/cache/inmemory/__tests__/__snapshots__/cache.ts.snap b/src/cache/inmemory/__tests__/__snapshots__/cache.ts.snap
index b03d1ba007a..a959b0709bb 100644
--- a/src/cache/inmemory/__tests__/__snapshots__/cache.ts.snap
+++ b/src/cache/inmemory/__tests__/__snapshots__/cache.ts.snap
@@ -227,3 +227,61 @@ Object {
   },
 }
 `;
+
+exports[`TypedDocumentNode<Data, Variables> should determine Data and Variables types of {write,read}{Query,Fragment} 1`] = `
+Object {
+  "Author:{\\"name\\":\\"John C. Mitchell\\"}": Object {
+    "__typename": "Author",
+    "name": "John C. Mitchell",
+  },
+  "Book:{\\"isbn\\":\\"0262133210\\"}": Object {
+    "__typename": "Book",
+    "author": Object {
+      "__ref": "Author:{\\"name\\":\\"John C. Mitchell\\"}",
+    },
+    "isbn": "0262133210",
+    "title": "Foundations for Programming Languages",
+  },
+  "ROOT_QUERY": Object {
+    "__typename": "Query",
+    "book({\\"isbn\\":\\"0262133210\\"})": Object {
+      "__ref": "Book:{\\"isbn\\":\\"0262133210\\"}",
+    },
+  },
+}
+`;
+
+exports[`TypedDocumentNode<Data, Variables> should determine Data and Variables types of {write,read}{Query,Fragment} 2`] = `
+Object {
+  "Author:{\\"name\\":\\"Harold Abelson\\"}": Object {
+    "__typename": "Author",
+    "name": "Harold Abelson",
+  },
+  "Author:{\\"name\\":\\"John C. Mitchell\\"}": Object {
+    "__typename": "Author",
+    "name": "John C. Mitchell",
+  },
+  "Book:{\\"isbn\\":\\"0262133210\\"}": Object {
+    "__typename": "Book",
+    "author": Object {
+      "__ref": "Author:{\\"name\\":\\"John C. Mitchell\\"}",
+    },
+    "isbn": "0262133210",
+    "title": "Foundations for Programming Languages",
+  },
+  "Book:{\\"isbn\\":\\"0262510871\\"}": Object {
+    "__typename": "Book",
+    "author": Object {
+      "__ref": "Author:{\\"name\\":\\"Harold Abelson\\"}",
+    },
+    "isbn": "0262510871",
+    "title": "Structure and Interpretation of Computer Programs",
+  },
+  "ROOT_QUERY": Object {
+    "__typename": "Query",
+    "book({\\"isbn\\":\\"0262133210\\"})": Object {
+      "__ref": "Book:{\\"isbn\\":\\"0262133210\\"}",
+    },
+  },
+}
+`;
diff --git a/src/cache/inmemory/__tests__/cache.ts b/src/cache/inmemory/__tests__/cache.ts
index f877e68ba66..b495e002d51 100644
--- a/src/cache/inmemory/__tests__/cache.ts
+++ b/src/cache/inmemory/__tests__/cache.ts
@@ -2,7 +2,7 @@ import gql, { disableFragmentWarnings } from 'graphql-tag';
 
 import { stripSymbols } from '../../../utilities/testing/stripSymbols';
 import { cloneDeep } from '../../../utilities/common/cloneDeep';
-import { makeReference, Reference, makeVar } from '../../../core';
+import { makeReference, Reference, makeVar, TypedDocumentNode, isReference } from '../../../core';
 import { InMemoryCache, InMemoryCacheConfig } from '../inMemoryCache';
 
 disableFragmentWarnings();
@@ -2496,3 +2496,159 @@ describe("ReactiveVar and makeVar", () => {
     });
   });
 });
+
+describe('TypedDocumentNode<Data, Variables>', () => {
+  type Book = {
+    isbn?: string;
+    title: string;
+    author: {
+      name: string;
+    };
+  };
+
+  const query: TypedDocumentNode<
+    { book: Book },
+    { isbn: string }
+  > = gql`query GetBook($isbn: String!) {
+    book(isbn: $isbn) {
+      title
+      author {
+        name
+      }
+    }
+  }`;
+
+  const fragment: TypedDocumentNode<Book> = gql`
+    fragment TitleAndAuthor on Book {
+      title
+      isbn
+      author {
+        name
+      }
+    }
+  `;
+
+  it('should determine Data and Variables types of {write,read}{Query,Fragment}', () => {
+    const cache = new InMemoryCache({
+      typePolicies: {
+        Query: {
+          fields: {
+            book(existing, { args, toReference }) {
+              return existing ?? (args && toReference({
+                __typename: "Book",
+                isbn: args.isbn,
+              }));
+            }
+          }
+        },
+
+        Book: {
+          keyFields: ["isbn"],
+        },
+
+        Author: {
+          keyFields: ["name"],
+        },
+      },
+    });
+
+    // We need to define these objects separately from calling writeQuery,
+    // because passing them directly to writeQuery will trigger excess property
+    // warnings due to the extra __typename and isbn fields. Internally, we
+    // almost never pass object literals to writeQuery or writeFragment, so
+    // excess property checks should not be a problem in practice.
+    const jcmAuthor = {
+      __typename: "Author",
+      name: "John C. Mitchell",
+    };
+
+    const ffplBook = {
+      __typename: "Book",
+      isbn: "0262133210",
+      title: "Foundations for Programming Languages",
+      author: jcmAuthor,
+    };
+
+    const ffplVariables = {
+      isbn: "0262133210",
+    };
+
+    cache.writeQuery({
+      query,
+      variables: ffplVariables,
+      data: {
+        book: ffplBook,
+      },
+    });
+
+    expect(cache.extract()).toMatchSnapshot();
+
+    const ffplQueryResult = cache.readQuery({
+      query,
+      variables: ffplVariables,
+    });
+
+    if (ffplQueryResult === null) throw new Error("null result");
+    expect(ffplQueryResult.book.isbn).toBeUndefined();
+    expect(ffplQueryResult.book.author.name).toBe(jcmAuthor.name);
+    expect(ffplQueryResult).toEqual({
+      book: {
+        __typename: "Book",
+        title: "Foundations for Programming Languages",
+        author: {
+          __typename: "Author",
+          name: "John C. Mitchell",
+        },
+      },
+    });
+
+    const sicpBook = {
+      __typename: "Book",
+      isbn: "0262510871",
+      title: "Structure and Interpretation of Computer Programs",
+      author: {
+        __typename: "Author",
+        name: "Harold Abelson",
+      },
+    };
+
+    const sicpRef = cache.writeFragment({
+      fragment,
+      data: sicpBook,
+    });
+
+    expect(isReference(sicpRef)).toBe(true);
+    expect(cache.extract()).toMatchSnapshot();
+
+    const ffplFragmentResult = cache.readFragment({
+      fragment,
+      id: cache.identify(ffplBook),
+    });
+    if (ffplFragmentResult === null) throw new Error("null result");
+    expect(ffplFragmentResult.title).toBe(ffplBook.title);
+    expect(ffplFragmentResult.author.name).toBe(ffplBook.author.name);
+    expect(ffplFragmentResult).toEqual(ffplBook);
+
+    // This uses the read function for the Query.book field.
+    const sicpReadResult = cache.readQuery({
+      query,
+      variables: {
+        isbn: sicpBook.isbn,
+      },
+    });
+    if (sicpReadResult === null) throw new Error("null result");
+    expect(sicpReadResult.book.isbn).toBeUndefined();
+    expect(sicpReadResult.book.title).toBe(sicpBook.title);
+    expect(sicpReadResult.book.author.name).toBe(sicpBook.author.name);
+    expect(sicpReadResult).toEqual({
+      book: {
+        __typename: "Book",
+        title: "Structure and Interpretation of Computer Programs",
+        author: {
+          __typename: "Author",
+          name: "Harold Abelson",
+        },
+      },
+    });
+  });
+});
diff --git a/src/core/ApolloClient.ts b/src/core/ApolloClient.ts
index 6fd3ca69062..b4d58404ad7 100644
--- a/src/core/ApolloClient.ts
+++ b/src/core/ApolloClient.ts
@@ -277,7 +277,7 @@ export class ApolloClient<TCacheShape> implements DataProxy {
    * a description of store reactivity.
    */
   public watchQuery<T = any, TVariables = OperationVariables>(
-    options: WatchQueryOptions<TVariables>,
+    options: WatchQueryOptions<TVariables, T>,
   ): ObservableQuery<T, TVariables> {
     if (this.defaultOptions.watchQuery) {
       options = compact(this.defaultOptions.watchQuery, options);
@@ -305,7 +305,7 @@ export class ApolloClient<TCacheShape> implements DataProxy {
    * server at all or just resolve from the cache, etc.
    */
   public query<T = any, TVariables = OperationVariables>(
-    options: QueryOptions<TVariables>,
+    options: QueryOptions<TVariables, T>,
   ): Promise<ApolloQueryResult<T>> {
     if (this.defaultOptions.query) {
       options = compact(this.defaultOptions.query, options);
@@ -347,7 +347,7 @@ export class ApolloClient<TCacheShape> implements DataProxy {
    * {@link Observable} which either emits received data or an error.
    */
   public subscribe<T = any, TVariables = OperationVariables>(
-    options: SubscriptionOptions<TVariables>,
+    options: SubscriptionOptions<TVariables, T>,
   ): Observable<FetchResult<T>> {
     return this.queryManager.startGraphQLSubscription<T>(options);
   }
@@ -362,7 +362,7 @@ export class ApolloClient<TCacheShape> implements DataProxy {
    * optimistic results. Is `false` by default.
    */
   public readQuery<T = any, TVariables = OperationVariables>(
-    options: DataProxy.Query<TVariables>,
+    options: DataProxy.Query<TVariables, T>,
     optimistic: boolean = false,
   ): T | null {
     return this.cache.readQuery<T, TVariables>(options, optimistic);
@@ -383,7 +383,7 @@ export class ApolloClient<TCacheShape> implements DataProxy {
    * optimistic results. Is `false` by default.
    */
   public readFragment<T = any, TVariables = OperationVariables>(
-    options: DataProxy.Fragment<TVariables>,
+    options: DataProxy.Fragment<TVariables, T>,
     optimistic: boolean = false,
   ): T | null {
     return this.cache.readFragment<T, TVariables>(options, optimistic);
diff --git a/src/core/ObservableQuery.ts b/src/core/ObservableQuery.ts
index e880d8c1277..5b01414b1e0 100644
--- a/src/core/ObservableQuery.ts
+++ b/src/core/ObservableQuery.ts
@@ -45,7 +45,7 @@ export class ObservableQuery<
   TData = any,
   TVariables = OperationVariables
 > extends Observable<ApolloQueryResult<TData>> {
-  public readonly options: WatchQueryOptions<TVariables>;
+  public readonly options: WatchQueryOptions<TVariables, TData>;
   public readonly queryId: string;
   public readonly queryName?: string;
 
@@ -72,7 +72,7 @@ export class ObservableQuery<
   }: {
     queryManager: QueryManager<any>;
     queryInfo: QueryInfo;
-    options: WatchQueryOptions<TVariables>;
+    options: WatchQueryOptions<TVariables, TData>;
   }) {
     super((observer: Observer<ApolloQueryResult<TData>>) =>
       this.onSubscribe(observer),
@@ -219,7 +219,7 @@ export class ObservableQuery<
       ));
     }
 
-    const reobserveOptions: Partial<WatchQueryOptions<TVariables>> = {
+    const reobserveOptions: Partial<WatchQueryOptions<TVariables, TData>> = {
       // Always disable polling for refetches.
       pollInterval: 0,
     };
@@ -249,7 +249,7 @@ export class ObservableQuery<
   }
 
   public fetchMore<K extends keyof TVariables>(
-    fetchMoreOptions: FetchMoreQueryOptions<TVariables, K> &
+    fetchMoreOptions: FetchMoreQueryOptions<TVariables, K, TData> &
       FetchMoreOptions<TData, TVariables>,
   ): Promise<ApolloQueryResult<TData>> {
     const combinedOptions = {
@@ -404,7 +404,7 @@ once, rather than every time you call fetchMore.`);
   }
 
   public setOptions(
-    newOptions: Partial<WatchQueryOptions<TVariables>>,
+    newOptions: Partial<WatchQueryOptions<TVariables, TData>>,
   ): Promise<ApolloQueryResult<TData>> {
     return this.reobserve(newOptions);
   }
@@ -469,7 +469,7 @@ once, rather than every time you call fetchMore.`);
   public updateQuery<TVars = TVariables>(
     mapFn: (
       previousQueryResult: TData,
-      options: Pick<WatchQueryOptions<TVars>, "variables">,
+      options: Pick<WatchQueryOptions<TVars, TData>, "variables">,
     ) => TData,
   ): void {
     const { queryManager } = this;
@@ -594,7 +594,7 @@ once, rather than every time you call fetchMore.`);
   }
 
   public reobserve(
-    newOptions?: Partial<WatchQueryOptions<TVariables>>,
+    newOptions?: Partial<WatchQueryOptions<TVariables, TData>>,
     newNetworkStatus?: NetworkStatus,
   ): Promise<ApolloQueryResult<TData>> {
     this.isTornDown = false;
diff --git a/src/core/QueryManager.ts b/src/core/QueryManager.ts
index 6966570b9d1..3a32535f22c 100644
--- a/src/core/QueryManager.ts
+++ b/src/core/QueryManager.ts
@@ -333,7 +333,7 @@ export class QueryManager<TStore> {
 
   public fetchQuery<TData, TVars>(
     queryId: string,
-    options: WatchQueryOptions<TVars>,
+    options: WatchQueryOptions<TVars, TData>,
     networkStatus?: NetworkStatus,
   ): Promise<ApolloQueryResult<TData>> {
     return this.fetchQueryObservable<TData, TVars>(
@@ -428,7 +428,7 @@ export class QueryManager<TStore> {
   }
 
   public watchQuery<T, TVariables = OperationVariables>(
-    options: WatchQueryOptions<TVariables>,
+    options: WatchQueryOptions<TVariables, T>,
   ): ObservableQuery<T, TVariables> {
     // assign variable default values if supplied
     options = {
@@ -462,7 +462,7 @@ export class QueryManager<TStore> {
   }
 
   public query<TData, TVars = OperationVariables>(
-    options: QueryOptions<TVars>,
+    options: QueryOptions<TVars, TData>,
   ): Promise<ApolloQueryResult<TData>> {
     invariant(
       options.query,
@@ -759,7 +759,7 @@ export class QueryManager<TStore> {
   private getResultsFromLink<TData, TVars>(
     queryInfo: QueryInfo,
     allowCacheWrite: boolean,
-    options: Pick<WatchQueryOptions<TVars>,
+    options: Pick<WatchQueryOptions<TVars, TData>,
       | "variables"
       | "context"
       | "fetchPolicy"
@@ -817,7 +817,7 @@ export class QueryManager<TStore> {
 
   public fetchQueryObservable<TData, TVars>(
     queryId: string,
-    options: WatchQueryOptions<TVars>,
+    options: WatchQueryOptions<TVars, TData>,
     // The initial networkStatus for this fetch, most often
     // NetworkStatus.loading, but also possibly fetchMore, poll, refetch,
     // or setVariables.
@@ -931,7 +931,7 @@ export class QueryManager<TStore> {
 
   private fetchQueryByPolicy<TData, TVars>(
     queryInfo: QueryInfo,
-    options: WatchQueryOptions<TVars>,
+    options: WatchQueryOptions<TVars, TData>,
     // The initial networkStatus for this fetch, most often
     // NetworkStatus.loading, but also possibly fetchMore, poll, refetch,
     // or setVariables.
diff --git a/src/core/Reobserver.ts b/src/core/Reobserver.ts
index e658985005a..1eea56eb9ce 100644
--- a/src/core/Reobserver.ts
+++ b/src/core/Reobserver.ts
@@ -17,13 +17,13 @@ import { invariant } from 'ts-invariant';
 export class Reobserver<TData, TVars> {
   constructor(
     private observer: Observer<ApolloQueryResult<TData>>,
-    private options: WatchQueryOptions<TVars>,
+    private options: WatchQueryOptions<TVars, TData>,
     // Almost certainly just a wrapper function around
     // QueryManager#fetchQueryObservable, but this small dose of
     // indirection means the Reobserver doesn't have to know/assume
     // anything about the QueryManager class.
     private fetch: (
-      options: WatchQueryOptions<TVars>,
+      options: WatchQueryOptions<TVars, TData>,
       newNetworkStatus?: NetworkStatus,
     ) => Concast<ApolloQueryResult<TData>>,
     // If we're polling, there may be times when we should avoid fetching,
@@ -37,7 +37,7 @@ export class Reobserver<TData, TVars> {
   private concast?: Concast<ApolloQueryResult<TData>>;
 
   public reobserve(
-    newOptions?: Partial<WatchQueryOptions<TVars>>,
+    newOptions?: Partial<WatchQueryOptions<TVars, TData>>,
     newNetworkStatus?: NetworkStatus,
   ): Promise<ApolloQueryResult<TData>> {
     if (newOptions) {
@@ -66,7 +66,7 @@ export class Reobserver<TData, TVars> {
     return (this.concast = concast).promise;
   }
 
-  public updateOptions(newOptions: Partial<WatchQueryOptions<TVars>>) {
+  public updateOptions(newOptions: Partial<WatchQueryOptions<TVars, TData>>) {
     Object.assign(this.options, compact(newOptions));
     this.updatePolling();
     return this;
diff --git a/src/core/types.ts b/src/core/types.ts
index 93036512e58..9792ab918f6 100644
--- a/src/core/types.ts
+++ b/src/core/types.ts
@@ -6,6 +6,8 @@ import { QueryInfo } from './QueryInfo';
 import { NetworkStatus } from './networkStatus';
 import { Resolver } from './LocalState';
 
+export { TypedDocumentNode } from '@graphql-typed-document-node/core';
+
 export type QueryListener = (queryInfo: QueryInfo) => void;
 
 export type OperationVariables = Record<string, any>;
diff --git a/src/core/watchQueryOptions.ts b/src/core/watchQueryOptions.ts
index d865367214f..3420a93b9da 100644
--- a/src/core/watchQueryOptions.ts
+++ b/src/core/watchQueryOptions.ts
@@ -1,4 +1,5 @@
 import { DocumentNode } from 'graphql';
+import { TypedDocumentNode } from '@graphql-typed-document-node/core';
 
 import { ApolloCache } from '../cache';
 import { FetchResult } from '../link/core';
@@ -34,14 +35,14 @@ export type ErrorPolicy = 'none' | 'ignore' | 'all';
 /**
  * Common options shared across all query interfaces.
  */
-export interface QueryBaseOptions<TVariables = OperationVariables> {
+export interface QueryBaseOptions<TVariables = OperationVariables, TData = any> {
   /**
    * A GraphQL document that consists of a single query to be sent down to the
    * server.
    */
   // TODO REFACTOR: rename this to document. Didn't do it yet because it's in a
   // lot of tests.
-  query: DocumentNode;
+  query: DocumentNode | TypedDocumentNode<TData, TVariables>;
 
   /**
    * A map going from variable name to variable value, where the variables are used
@@ -63,8 +64,8 @@ export interface QueryBaseOptions<TVariables = OperationVariables> {
 /**
  * Query options.
  */
-export interface QueryOptions<TVariables = OperationVariables>
-  extends QueryBaseOptions<TVariables> {
+export interface QueryOptions<TVariables = OperationVariables, TData = any>
+  extends QueryBaseOptions<TVariables, TData> {
   /**
    * Specifies the {@link FetchPolicy} to be used for this query
    */
@@ -74,8 +75,8 @@ export interface QueryOptions<TVariables = OperationVariables>
 /**
  * We can change these options to an ObservableQuery
  */
-export interface ModifiableWatchQueryOptions<TVariables = OperationVariables>
-  extends QueryBaseOptions<TVariables> {
+export interface ModifiableWatchQueryOptions<TVariables = OperationVariables, TData = any>
+  extends QueryBaseOptions<TVariables, TData> {
   /**
    * The time interval (in milliseconds) on which this query should be
    * refetched from the server.
@@ -104,9 +105,9 @@ export interface ModifiableWatchQueryOptions<TVariables = OperationVariables>
 /**
  * Watched query options.
  */
-export interface WatchQueryOptions<TVariables = OperationVariables>
-  extends QueryBaseOptions<TVariables>,
-    ModifiableWatchQueryOptions<TVariables> {
+export interface WatchQueryOptions<TVariables = OperationVariables, TData = any>
+  extends QueryBaseOptions<TVariables, TData>,
+    ModifiableWatchQueryOptions<TVariables, TData> {
   /**
    * Specifies the {@link FetchPolicy} to be used for this query.
    */
@@ -117,8 +118,8 @@ export interface WatchQueryOptions<TVariables = OperationVariables>
   nextFetchPolicy?: WatchQueryFetchPolicy;
 }
 
-export interface FetchMoreQueryOptions<TVariables, K extends keyof TVariables> {
-  query?: DocumentNode;
+export interface FetchMoreQueryOptions<TVariables, K extends keyof TVariables, TData = any> {
+  query?: DocumentNode | TypedDocumentNode<TData, TVariables>;
   variables?: Pick<TVariables, K>;
   context?: any;
 }
@@ -140,19 +141,19 @@ export type SubscribeToMoreOptions<
   TSubscriptionVariables = OperationVariables,
   TSubscriptionData = TData
 > = {
-  document: DocumentNode;
+  document: DocumentNode | TypedDocumentNode<TSubscriptionData, TSubscriptionVariables>;
   variables?: TSubscriptionVariables;
   updateQuery?: UpdateQueryFn<TData, TSubscriptionVariables, TSubscriptionData>;
   onError?: (error: Error) => void;
   context?: Record<string, any>;
 };
 
-export interface SubscriptionOptions<TVariables = OperationVariables> {
+export interface SubscriptionOptions<TVariables = OperationVariables, TData = any> {
   /**
    * A GraphQL document, often created with `gql` from the `graphql-tag`
    * package, that contains a single subscription inside of it.
    */
-  query: DocumentNode;
+  query: DocumentNode | TypedDocumentNode<TData, TVariables>;
 
   /**
    * An object that maps from the name of a variable as used in the subscription
@@ -256,7 +257,7 @@ export interface MutationOptions<
    * A GraphQL document, often created with `gql` from the `graphql-tag`
    * package, that contains a single mutation inside of it.
    */
-  mutation: DocumentNode;
+  mutation: DocumentNode | TypedDocumentNode<T, TVariables>;
 
   /**
    * The context to be passed to the link execution chain. This context will
diff --git a/src/react/components/types.ts b/src/react/components/types.ts
index 7229777f6d7..83dea55043f 100644
--- a/src/react/components/types.ts
+++ b/src/react/components/types.ts
@@ -1,4 +1,5 @@
 import { DocumentNode } from 'graphql';
+import { TypedDocumentNode } from '@graphql-typed-document-node/core';
 
 import { OperationVariables } from '../../core';
 import {
@@ -16,14 +17,14 @@ export interface QueryComponentOptions<
   TVariables = OperationVariables
 > extends QueryFunctionOptions<TData, TVariables> {
   children: (result: QueryResult<TData, TVariables>) => JSX.Element | null;
-  query: DocumentNode;
+  query: DocumentNode | TypedDocumentNode<TData, TVariables>;
 }
 
 export interface MutationComponentOptions<
   TData = any,
   TVariables = OperationVariables
 > extends BaseMutationOptions<TData, TVariables> {
-  mutation: DocumentNode;
+  mutation: DocumentNode | TypedDocumentNode<TData, TVariables>;
   children: (
     mutateFunction: MutationFunction<TData, TVariables>,
     result: MutationResult<TData>
@@ -34,6 +35,6 @@ export interface SubscriptionComponentOptions<
   TData = any,
   TVariables = OperationVariables
 > extends BaseSubscriptionOptions<TData, TVariables> {
-  subscription: DocumentNode;
+  subscription: DocumentNode | TypedDocumentNode<TData, TVariables>;
   children?: null | ((result: SubscriptionResult<TData>) => JSX.Element | null);
 }
diff --git a/src/react/data/QueryData.ts b/src/react/data/QueryData.ts
index 90a24363f1c..e552a3b057f 100644
--- a/src/react/data/QueryData.ts
+++ b/src/react/data/QueryData.ts
@@ -457,7 +457,7 @@ export class QueryData<TData, TVariables> extends OperationData {
     this.currentObservable!.refetch(variables);
 
   private obsFetchMore = <K extends keyof TVariables>(
-    fetchMoreOptions: FetchMoreQueryOptions<TVariables, K> &
+    fetchMoreOptions: FetchMoreQueryOptions<TVariables, K, TData> &
       FetchMoreOptions<TData, TVariables>
   ) => this.currentObservable!.fetchMore(fetchMoreOptions);
 
diff --git a/src/react/hoc/types.ts b/src/react/hoc/types.ts
index 909878aa6f3..4c0ec8c3ec8 100644
--- a/src/react/hoc/types.ts
+++ b/src/react/hoc/types.ts
@@ -24,7 +24,7 @@ export interface QueryControls<
   loading: boolean;
   variables: TGraphQLVariables;
   fetchMore: (
-    fetchMoreOptions: FetchMoreQueryOptions<TGraphQLVariables, any> &
+    fetchMoreOptions: FetchMoreQueryOptions<TGraphQLVariables, any, TData> &
       FetchMoreOptions<TData, TGraphQLVariables>
   ) => Promise<ApolloQueryResult<TData>>;
   refetch: (variables?: TGraphQLVariables) => Promise<ApolloQueryResult<TData>>;
diff --git a/src/react/hooks/useLazyQuery.ts b/src/react/hooks/useLazyQuery.ts
index 987622915e9..8032639ad98 100644
--- a/src/react/hooks/useLazyQuery.ts
+++ b/src/react/hooks/useLazyQuery.ts
@@ -1,11 +1,12 @@
 import { DocumentNode } from 'graphql';
+import { TypedDocumentNode } from '@graphql-typed-document-node/core';
 
 import { LazyQueryHookOptions, QueryTuple } from '../types/types';
 import { useBaseQuery } from './utils/useBaseQuery';
 import { OperationVariables } from '../../core';
 
 export function useLazyQuery<TData = any, TVariables = OperationVariables>(
-  query: DocumentNode,
+  query: DocumentNode | TypedDocumentNode<TData, TVariables>,
   options?: LazyQueryHookOptions<TData, TVariables>
 ) {
   return useBaseQuery<TData, TVariables>(query, options, true) as QueryTuple<
diff --git a/src/react/hooks/useMutation.ts b/src/react/hooks/useMutation.ts
index fbc2202e4b8..28f96618c0f 100644
--- a/src/react/hooks/useMutation.ts
+++ b/src/react/hooks/useMutation.ts
@@ -1,5 +1,6 @@
 import { useContext, useState, useRef, useEffect } from 'react';
 import { DocumentNode } from 'graphql';
+import { TypedDocumentNode } from '@graphql-typed-document-node/core';
 
 import { MutationHookOptions, MutationTuple } from '../types/types';
 import { MutationData } from '../data';
@@ -7,7 +8,7 @@ import { OperationVariables } from '../../core';
 import { getApolloContext } from '../context';
 
 export function useMutation<TData = any, TVariables = OperationVariables>(
-  mutation: DocumentNode,
+  mutation: DocumentNode | TypedDocumentNode<TData, TVariables>,
   options?: MutationHookOptions<TData, TVariables>
 ): MutationTuple<TData, TVariables> {
   const context = useContext(getApolloContext());
diff --git a/src/react/hooks/useQuery.ts b/src/react/hooks/useQuery.ts
index ae226cebc91..bf75ad0e323 100644
--- a/src/react/hooks/useQuery.ts
+++ b/src/react/hooks/useQuery.ts
@@ -1,11 +1,12 @@
 import { DocumentNode } from 'graphql';
+import { TypedDocumentNode } from '@graphql-typed-document-node/core';
 
 import { QueryHookOptions, QueryResult } from '../types/types';
 import { useBaseQuery } from './utils/useBaseQuery';
 import { OperationVariables } from '../../core';
 
 export function useQuery<TData = any, TVariables = OperationVariables>(
-  query: DocumentNode,
+  query: DocumentNode | TypedDocumentNode<TData, TVariables>,
   options?: QueryHookOptions<TData, TVariables>
 ) {
   return useBaseQuery<TData, TVariables>(query, options, false) as QueryResult<
diff --git a/src/react/hooks/useSubscription.ts b/src/react/hooks/useSubscription.ts
index aa4b6f1e372..d553b9fbef3 100644
--- a/src/react/hooks/useSubscription.ts
+++ b/src/react/hooks/useSubscription.ts
@@ -1,5 +1,6 @@
 import { useContext, useState, useRef, useEffect } from 'react';
 import { DocumentNode } from 'graphql';
+import { TypedDocumentNode } from '@graphql-typed-document-node/core';
 
 import { SubscriptionHookOptions } from '../types/types';
 import { SubscriptionData } from '../data';
@@ -7,7 +8,7 @@ import { OperationVariables } from '../../core';
 import { getApolloContext } from '../context';
 
 export function useSubscription<TData = any, TVariables = OperationVariables>(
-  subscription: DocumentNode,
+  subscription: DocumentNode | TypedDocumentNode<TData, TVariables>,
   options?: SubscriptionHookOptions<TData, TVariables>
 ) {
   const context = useContext(getApolloContext());
diff --git a/src/react/hooks/utils/useBaseQuery.ts b/src/react/hooks/utils/useBaseQuery.ts
index ac293453770..2d5083097e0 100644
--- a/src/react/hooks/utils/useBaseQuery.ts
+++ b/src/react/hooks/utils/useBaseQuery.ts
@@ -1,5 +1,6 @@
 import { useContext, useEffect, useReducer, useRef } from 'react';
 import { DocumentNode } from 'graphql';
+import { TypedDocumentNode } from '@graphql-typed-document-node/core';
 
 import {
   QueryHookOptions,
@@ -13,7 +14,7 @@ import { OperationVariables } from '../../../core';
 import { getApolloContext } from '../../context';
 
 export function useBaseQuery<TData = any, TVariables = OperationVariables>(
-  query: DocumentNode,
+  query: DocumentNode | TypedDocumentNode<TData, TVariables>,
   options?: QueryHookOptions<TData, TVariables>,
   lazy = false
 ) {
diff --git a/src/react/types/types.ts b/src/react/types/types.ts
index cfba43611df..cbd52ad284f 100644
--- a/src/react/types/types.ts
+++ b/src/react/types/types.ts
@@ -1,5 +1,6 @@
 import { ReactNode } from 'react';
 import { DocumentNode } from 'graphql';
+import { TypedDocumentNode } from '@graphql-typed-document-node/core';
 
 import { Observable } from '../../utilities';
 import { FetchResult } from '../../link/core';
@@ -63,13 +64,14 @@ export type ObservableQueryFields<TData, TVariables> = Pick<
   | 'variables'
 > & {
   fetchMore: (<K extends keyof TVariables>(
-    fetchMoreOptions: FetchMoreQueryOptions<TVariables, K> &
+    fetchMoreOptions: FetchMoreQueryOptions<TVariables, K, TData> &
       FetchMoreOptions<TData, TVariables>
   ) => Promise<ApolloQueryResult<TData>>) &
     (<TData2, TVariables2, K extends keyof TVariables2>(
-      fetchMoreOptions: { query?: DocumentNode } & FetchMoreQueryOptions<
+      fetchMoreOptions: { query?: DocumentNode | TypedDocumentNode<TData, TVariables> } & FetchMoreQueryOptions<
         TVariables2,
-        K
+        K,
+        TData
       > &
         FetchMoreOptions<TData2, TVariables2>
     ) => Promise<ApolloQueryResult<TData2>>);
@@ -88,24 +90,24 @@ export interface QueryResult<TData = any, TVariables = OperationVariables>
 export interface QueryDataOptions<TData = any, TVariables = OperationVariables>
   extends QueryFunctionOptions<TData, TVariables> {
   children?: (result: QueryResult<TData, TVariables>) => ReactNode;
-  query: DocumentNode;
+  query: DocumentNode | TypedDocumentNode<TData, TVariables>;
 }
 
 export interface QueryHookOptions<TData = any, TVariables = OperationVariables>
   extends QueryFunctionOptions<TData, TVariables> {
-  query?: DocumentNode;
+  query?: DocumentNode | TypedDocumentNode<TData, TVariables>;
 }
 
 export interface LazyQueryHookOptions<
   TData = any,
   TVariables = OperationVariables
 > extends Omit<QueryFunctionOptions<TData, TVariables>, 'skip'> {
-  query?: DocumentNode;
+  query?: DocumentNode | TypedDocumentNode<TData, TVariables>;
 }
 
 export interface QueryPreviousData<TData, TVariables> {
   client?: ApolloClient<object>;
-  query?: DocumentNode;
+  query?: DocumentNode | TypedDocumentNode<TData, TVariables>;
   observableQueryOptions?: {};
   result?: QueryResult<TData, TVariables> | null;
   loading?: boolean;
@@ -203,12 +205,12 @@ export interface MutationHookOptions<
   TData = any,
   TVariables = OperationVariables
 > extends BaseMutationOptions<TData, TVariables> {
-  mutation?: DocumentNode;
+  mutation?: DocumentNode | TypedDocumentNode<TData, TVariables>;
 }
 
 export interface MutationDataOptions<TData = any, TVariables = OperationVariables>
   extends BaseMutationOptions<TData, TVariables> {
-  mutation: DocumentNode;
+  mutation: DocumentNode | TypedDocumentNode<TData, TVariables>;
 }
 
 export type MutationTuple<TData, TVariables> = [
@@ -250,14 +252,14 @@ export interface SubscriptionHookOptions<
   TData = any,
   TVariables = OperationVariables
 > extends BaseSubscriptionOptions<TData, TVariables> {
-  subscription?: DocumentNode;
+  subscription?: DocumentNode | TypedDocumentNode<TData, TVariables>;
 }
 
 export interface SubscriptionDataOptions<
   TData = any,
   TVariables = OperationVariables
 > extends BaseSubscriptionOptions<TData, TVariables> {
-  subscription: DocumentNode;
+  subscription: DocumentNode | TypedDocumentNode<TData, TVariables>;
   children?: null | ((result: SubscriptionResult<TData>) => JSX.Element | null);
 }