A journal club for -omicsy things @ UCLA. Send me a paper if you'd like to suggest one, otherwise I will choose.
We meet at the Luskin Center Bar Fridays at 5:30 for beer and science. If you're reading this, feel free to stop by.
We are modeled after Jeff Ross-Ibarra's REHAB, please check there for information on the format. In short, no one presents the paper and we jump in as soon as the beer arrives.
Here's some data on who's suggesting papers:
May 11th, 2018 Matz et al 2018 Potential and limits for rapid genetic adaptation to warming in a Great Barrier Reef coral [blame Katie]
May 4th, 2018 Veeramah et al 2018 Population genomic analysis of elongated skulls reveals extensive female-biased immigration in Early Medieval Bavaria [blame Katie]
April 27th, 2018 Small et al 2018 Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition [blame Katie]
April 20th, 2018 Kremling et al 2018 Dysregulation of expression correlates with rare-allele burden and fitness loss in maize [blame Arun]
April 13th, 2018 Chen et al 2018 The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases [blame Katie]
March 16th, 2018 Alpert Sugden et al 2018 Localization of adaptive variants in human genomes using averaged one-dependence estimation [blame Daniel]
March 9th, 2018 Danko et al 2018 Dynamic evolution of regulatory element ensembles in primate CD4+ T cells [blame Arun]
March 2nd, 2018 No journal club -- go to UCLA Computational Genomics Winter Institute instead.
February 23rd, 2018 Lake et al 2018 Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain [blame Jill]
February 9th, 2018 Combs et al 2017 Spatial population genomics of the brown rat (Rattus norvegicus) in New York City [blame Katie]
February 2nd, 2018 Kong et al 2018 The nature of nurture: Effects of parental genotypes [blame Yoni]
January 26th, 2018 Hernandez et al 2017 Singleton Variants Dominate the Genetic Architecture of Human Gene Expression [blame Arun]
January 12th, 2018 Mumbach, Satpathy, Boyle and Dai et al 2017 Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements [blame Mike]
December 8th, 2017 Houshdaran et al 2016 Aberrant Endometrial DNA Methylome and Associated Gene Expression in Women with Endometriosis [blame Katie]
November 17th, 2017 Angermueller et al 2017 DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning [blame Colin]
November 3rd, 2017 Raj et al 2017 Integrative analyses of splicing in the aging brain: role in susceptibility to Alzheimer's Disease [blame Yoni]
October 27th, 2017 Ongen et al 2017. Estimating the causal tissues for complex traits and diseases [blame Arun]
October 20th, 2017 He et al 2017. Unified Sequence-Based Association Tests Allowing for Multiple Functional Annotations and Meta-analysis of Noncoding Variation in Metabochip Data [blame Albert]
October 13th, 2017 Weissensteiner et al 2017. Combination of short-read, long-read, and optical mapping assemblies reveals large-scale tandem repeat arrays with population genetic implications [blame Daniel]
October 6th, 2017 Rubin, Barajas, and Furlan-Magaril et al 2017. Lineage-specific dynamic and pre-established enhancer–promoter contacts cooperate in terminal differentiation [blame James]
September 29th, 2017 Lareau and Aryee 2017. diffloop: a computational framework for identifying and analyzing differential DNA loops from sequencing data [blame Katie]
September 21st, 2017 Castel et al 2017. Modified penetrance of coding variants by cis-regulatory variation shapes human traits [blame James]
September 15th, 2017 Mostafavi et al 2017. Identifying genetic variants that affect viability in large cohorts [blame Arun]
August 4th, 2017 Cortes and Dendrou et al 2017. Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank [blame Colin]
No journal club -- go to UCLA Computational Genomics Summer Institute instead.
June 30th, 2017 Hammerschlag et al 2017. Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits [blame Albert]
June 23rd, 2017 Boyle et al 2017. An Expanded View of Complex Traits: From Polygenic to Omnigenic [blame Catharine, James, Arun]
- Bonus: Goldstein 2009. Common Genetic Variation and Human Traits [blame James, Arun]
- Bonus: Rockman 2012. The QTN program and the alleles that matter for evolution: all that's gold does not glitter [blame Arun]
June 16th, 2017 McLaughlin et al 2017. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia [blame Alex]
June 9th, 2017 Glodzik et al 2017. A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers [blame Mike]
June 2nd, 2017 Knouse et al 2016. Assessment of megabase-scale somatic copy number variation using single cell sequencing [blame Daniel]
May 25th, 2017 Mathieson et al 2015. Genome-wide patterns of selection in 230 ancient Eurasians [blame Arun] Note: date change
May 19th, 2017 No journal club -- go to Brewin' Talks!
May 12th, 2017 Pala and Zappala et al 2017. Population- and individual-specific regulatory variation in Sardinia [blame Arun]
May 5th, 2017 Corces et al 2017. Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution [blame Mike]
April 28th, 2017 Saleheen & Natarajan et al 2017. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity [blame Alex]
April 21st, 2017 Yue et al 2017. Contrasting evolutionary genome dynamics between domesticated and wild yeasts [blame James]
April 14th, 2017: Chiang et al 2017. The impact of structural variation on human gene expression [blame Colin]
April 7th, 2017: Poplin et al 2016. Creating a universal SNP and small indel variant caller with deep neural networks [blame Arun]