diff --git a/pyupgrade/_plugins/six_calls.py b/pyupgrade/_plugins/six_calls.py
index 3fd30cd7..1bb50fae 100644
--- a/pyupgrade/_plugins/six_calls.py
+++ b/pyupgrade/_plugins/six_calls.py
@@ -51,7 +51,7 @@
     'assertRegex': '{args[0]}.assertRegex({rest})',
 }
 SIX_INT2BYTE_TMPL = 'bytes(({args[0]},))'
-RAISE_FROM_TMPL = 'raise {args[0]} from {rest}'
+RAISE_FROM_TMPL = 'raise {args[0]} from {args[1]}'
 RERAISE_TMPL = 'raise'
 RERAISE_2_TMPL = 'raise {args[1]}.with_traceback(None)'
 RERAISE_3_TMPL = 'raise {args[1]}.with_traceback({args[2]})'
diff --git a/tests/features/six_test.py b/tests/features/six_test.py
index 2b87b8ff..e1f6cd88 100644
--- a/tests/features/six_test.py
+++ b/tests/features/six_test.py
@@ -126,6 +126,16 @@ def test_fix_six_noop(s):
             'six.raise_from(exc, exc_from)\n',
             'raise exc from exc_from\n',
         ),
+        pytest.param(
+            'six.raise_from(\n'
+            '    e,\n'
+            '    f,\n'
+            ')',
+
+            'raise e from f',
+
+            id='six raise_from across multiple lines',
+        ),
         (
             'six.reraise(tp, exc, tb)\n',
             'raise exc.with_traceback(tb)\n',