diff --git a/crates/ruff_linter/resources/test/fixtures/flake8_comprehensions/C419_1.py b/crates/ruff_linter/resources/test/fixtures/flake8_comprehensions/C419_1.py
index dffeed1e9cc74..069c90b982590 100644
--- a/crates/ruff_linter/resources/test/fixtures/flake8_comprehensions/C419_1.py
+++ b/crates/ruff_linter/resources/test/fixtures/flake8_comprehensions/C419_1.py
@@ -3,8 +3,18 @@
 max([x.val for x in bar])
 sum([x.val for x in bar], 0)
 
-# Ok
+# OK
 sum(x.val for x in bar)
 min(x.val for x in bar)
 max(x.val for x in bar)
 sum(x.val for x in bar, 0)
+
+# Multi-line
+sum(
+    [
+        delta
+        for delta in timedelta_list
+        if delta
+    ],
+    dt.timedelta(),
+)
diff --git a/crates/ruff_linter/src/rules/flake8_comprehensions/rules/unnecessary_comprehension_in_call.rs b/crates/ruff_linter/src/rules/flake8_comprehensions/rules/unnecessary_comprehension_in_call.rs
index 86c6ba95e0745..9cde32f2ab353 100644
--- a/crates/ruff_linter/src/rules/flake8_comprehensions/rules/unnecessary_comprehension_in_call.rs
+++ b/crates/ruff_linter/src/rules/flake8_comprehensions/rules/unnecessary_comprehension_in_call.rs
@@ -1,10 +1,10 @@
 use ruff_python_ast::{self as ast, Expr, Keyword};
 
-use ruff_diagnostics::Violation;
 use ruff_diagnostics::{Diagnostic, FixAvailability};
+use ruff_diagnostics::{Edit, Fix, Violation};
 use ruff_macros::{derive_message_formats, violation};
 use ruff_python_ast::helpers::any_over_expr;
-use ruff_text_size::Ranged;
+use ruff_text_size::{Ranged, TextSize};
 
 use crate::checkers::ast::Checker;
 
@@ -112,9 +112,30 @@ pub(crate) fn unnecessary_comprehension_in_call(
     }
 
     let mut diagnostic = Diagnostic::new(UnnecessaryComprehensionInCall, arg.range());
-    diagnostic.try_set_fix(|| {
-        fixes::fix_unnecessary_comprehension_in_call(expr, checker.locator(), checker.stylist())
-    });
+
+    if args.len() == 1 {
+        // If there's only one argument, remove the list or set brackets.
+        diagnostic.try_set_fix(|| {
+            fixes::fix_unnecessary_comprehension_in_call(expr, checker.locator(), checker.stylist())
+        });
+    } else {
+        // If there are multiple arguments, replace the list or set brackets with parentheses.
+        // If a function call has multiple arguments, one of which is a generator, then the
+        // generator must be parenthesized.
+
+        // Replace `[` with `(`.
+        let collection_start = Edit::replacement(
+            "(".to_string(),
+            arg.start(),
+            arg.start() + TextSize::from(1),
+        );
+
+        // Replace `]` with `)`.
+        let collection_end =
+            Edit::replacement(")".to_string(), arg.end() - TextSize::from(1), arg.end());
+
+        diagnostic.set_fix(Fix::unsafe_edits(collection_start, [collection_end]));
+    }
     checker.diagnostics.push(diagnostic);
 }
 
diff --git a/crates/ruff_linter/src/rules/flake8_comprehensions/snapshots/ruff_linter__rules__flake8_comprehensions__tests__preview__C419_C419_1.py.snap b/crates/ruff_linter/src/rules/flake8_comprehensions/snapshots/ruff_linter__rules__flake8_comprehensions__tests__preview__C419_C419_1.py.snap
index 404ea341f0022..1c30178ac47d2 100644
--- a/crates/ruff_linter/src/rules/flake8_comprehensions/snapshots/ruff_linter__rules__flake8_comprehensions__tests__preview__C419_C419_1.py.snap
+++ b/crates/ruff_linter/src/rules/flake8_comprehensions/snapshots/ruff_linter__rules__flake8_comprehensions__tests__preview__C419_C419_1.py.snap
@@ -52,7 +52,7 @@ C419_1.py:3:5: C419 [*] Unnecessary list comprehension
   3 |+max(x.val for x in bar)
 4 4 | sum([x.val for x in bar], 0)
 5 5 | 
-6 6 | # Ok
+6 6 | # OK
 
 C419_1.py:4:5: C419 [*] Unnecessary list comprehension
   |
@@ -61,7 +61,7 @@ C419_1.py:4:5: C419 [*] Unnecessary list comprehension
 4 | sum([x.val for x in bar], 0)
   |     ^^^^^^^^^^^^^^^^^^^^ C419
 5 | 
-6 | # Ok
+6 | # OK
   |
   = help: Remove unnecessary list comprehension
 
@@ -70,7 +70,37 @@ C419_1.py:4:5: C419 [*] Unnecessary list comprehension
 2 2 | min([x.val for x in bar])
 3 3 | max([x.val for x in bar])
 4   |-sum([x.val for x in bar], 0)
-  4 |+sum(x.val for x in bar, 0)
+  4 |+sum((x.val for x in bar), 0)
 5 5 | 
-6 6 | # Ok
+6 6 | # OK
 7 7 | sum(x.val for x in bar)
+
+C419_1.py:14:5: C419 [*] Unnecessary list comprehension
+   |
+12 |   # Multi-line
+13 |   sum(
+14 |       [
+   |  _____^
+15 | |         delta
+16 | |         for delta in timedelta_list
+17 | |         if delta
+18 | |     ],
+   | |_____^ C419
+19 |       dt.timedelta(),
+20 |   )
+   |
+   = help: Remove unnecessary list comprehension
+
+ℹ Unsafe fix
+11 11 | 
+12 12 | # Multi-line
+13 13 | sum(
+14    |-    [
+   14 |+    (
+15 15 |         delta
+16 16 |         for delta in timedelta_list
+17 17 |         if delta
+18    |-    ],
+   18 |+    ),
+19 19 |     dt.timedelta(),
+20 20 | )