diff --git a/Cargo.lock b/Cargo.lock
index 70245d286e5c6..9e252ab60126e 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -2291,6 +2291,7 @@ dependencies = [
  "rustc-hash",
  "serde",
  "smallvec",
+ "static_assertions",
 ]
 
 [[package]]
diff --git a/crates/ruff_python_ast/Cargo.toml b/crates/ruff_python_ast/Cargo.toml
index 21c7546c9209d..b85f740223267 100644
--- a/crates/ruff_python_ast/Cargo.toml
+++ b/crates/ruff_python_ast/Cargo.toml
@@ -28,6 +28,7 @@ once_cell = { workspace = true }
 rustc-hash = { workspace = true }
 serde = { workspace = true, optional = true }
 smallvec = { workspace = true }
+static_assertions = "1.1.0"
 
 [dev-dependencies]
 insta = { workspace = true }
diff --git a/crates/ruff_python_ast/src/nodes.rs b/crates/ruff_python_ast/src/nodes.rs
index 2b8420c625325..f42f831c763a6 100644
--- a/crates/ruff_python_ast/src/nodes.rs
+++ b/crates/ruff_python_ast/src/nodes.rs
@@ -3044,3 +3044,16 @@ impl Ranged for crate::nodes::ArgWithDefault {
         self.range
     }
 }
+
+#[cfg(target_pointer_width = "64")]
+mod size_assertions {
+    #[allow(clippy::wildcard_imports)]
+    use super::*;
+    use static_assertions::assert_eq_size;
+
+    assert_eq_size!(Stmt, [u8; 168]);
+    assert_eq_size!(Expr, [u8; 80]);
+    assert_eq_size!(Constant, [u8; 32]);
+    assert_eq_size!(Pattern, [u8; 96]);
+    assert_eq_size!(Mod, [u8; 64]);
+}