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<title>ANRF Past Grant Awards</title>
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<td width="88%"><font color="#400080"><font face="Bookman Old Style" size="5">A</font><font
size="4" face="Bookman Old Style">RTHRITIS </font><font face="Bookman Old Style" size="5">N</font><font
size="4" face="Bookman Old Style">ATIONAL </font><font face="Bookman Old Style" size="5">R</font><font
size="4" face="Bookman Old Style">ESEARCH </font><font face="Bookman Old Style" size="5">F</font><font
size="4" face="Bookman Old Style">OUNDATION</font></font></td>
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<td><font color="#FF0000"><big><b><u>Grant Awards Overview</u></b></big></font><p><strong><font
size="3" color="#000000">The Arthritis National Research Foundation is proud to support
young investigators studying the causes of arthritis. Their discoveries have led to the
development of important new treatments to help those who spend each day in pain. The
following table describes the grants awarded over the last five years.</font></strong></p>
<p><strong><font size="3" color="#000000">&nbsp;</font></strong></td>
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<td WIDTH="80" VALIGN="top"><dir>
<i><b><font FACE="Arial" SIZE="2"><p align="left"></font><font face="Arial" size="3"
color="#400080">Date </font></b></i></p>
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<td WIDTH="520" VALIGN="top"><dir>
<i><b><font FACE="Arial" SIZE="2"><p></font><font face="Arial" size="3" color="#400080">Grants
Awarded</font></b></i></p>
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<td WIDTH="80" VALIGN="top"><p ALIGN="CENTER"><strong><font face="Times New Roman"
size="3">1998-99</font></strong></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">Elizabeth Mellins, M.D., Stanford University
Medical Center: </i>$40,000 to study the genetics of rheumatoid arthritis.<b> </b>Dr.
Mellins is examining if inherited genetic alterations in the recognition mechanism of the
immune system are defective and cause RA patients to identify certain self-antigens as
foreign.</font></p>
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<td WIDTH="80" VALIGN="top"><p ALIGN="CENTER"><strong><font face="Times New Roman"
size="3">1998-99</font></strong></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">Susan Kovats, Ph.D., Beckman Research Institute,
City of Hope:</i> $35,000 to study the nature of self-antigens in rheumatoid<b> </b>arthritis.<b>
</b>This study focuses on whether tissue damage or infection confuses the recognition
mechanism of the immune system, causing attack on self-tissues.</font></p>
</dir>
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<td WIDTH="80" VALIGN="top"><p ALIGN="CENTER"><strong><font face="Times New Roman"
size="3">1998-99</font></strong></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">Paul Utz, M.D., Harvard Medical School:</i>
$40,000 to study cell death&#146;s role in the development of autoimmune diseases.<b> </b>Dr.
Utz is focusing<b> </b>on<b> </b>the mechanism of how proteins released from dying
self-cells can be modified, then stimulate the patient&#146;s immune system.</font></p>
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<td WIDTH="80" VALIGN="top"><p ALIGN="CENTER"><strong><font face="Times New Roman"
size="3">1998-99</font></strong></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">Rebecca Tuetken, M.D., Ph.D., University of Iowa:
</i>$40,000 to study how the immune system recognizes and reacts against foreign and
self-DNA. The study will provide insight to the innate immune response to bacterial DNA
and the pathogenesis of SLE.</font></p>
</dir>
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<td WIDTH="80" VALIGN="top"><strong><font face="Times New Roman" size="3">&nbsp;</font></strong><p
ALIGN="CENTER"><strong><font face="Times New Roman" size="3">1997-98</font></strong></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">Morteza Setareh, Ph.D., Scripps Research
Institute</i>:<i> </i>$38,000 to study the molecular make-up of genes and the mechanism
whereby an autoimmune response is triggered as in arthritis, lupus and other rheumatic
diseases.</font></p>
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<td WIDTH="80" VALIGN="top"><p ALIGN="CENTER"><font size="3"><strong>1997-98</strong></font></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">Arunan Kaliyaperumal, Ph.D., Northwestern
University</i>:<i> </i>$38,000 to study the etiologic mechanism of Systemic Lupus
Erythematosus (Lupus) and design an autoantigen-specific therapy to block the autoimmune
response in Lupus.</font></p>
</dir>
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<td WIDTH="80" VALIGN="top"><p ALIGN="CENTER"><font size="3"><strong>1997-98</strong></font></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">Mariana Linker-Israeli, Ph.D., Cedars-Sinai
Medical Center</i>: $38,000 for a project examining the cellular and molecular
characteristics of patients with Lupus (SLE). By studying the susceptibility genes
involved, Dr. Linker-Israeli hopes to devise screening methods and targeted regimens of
therapy.</font></p>
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<td WIDTH="80" VALIGN="top"><p ALIGN="CENTER"><font size="3"><strong>1994-95/</strong></font></p>
<p ALIGN="CENTER"><font size="3"><strong>1996-97</strong></font></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">Chaim Jacob, M.D., Ph.D., University of Southern
California</i>: $50,000 for Systemic Lupus Erythematosus research utilizing new screening
techniques to test Lupus genes for identifiable mutations, which could be targets for gene
therapy in the future.</font></p>
</dir>
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<td WIDTH="80" VALIGN="top"><p ALIGN="CENTER"><font size="3"><strong>1996-97</strong></font></p>
<p ALIGN="CENTER"><font size="3"><strong>&nbsp;</strong></font></p>
<p ALIGN="CENTER"><font size="3"><strong>&nbsp;</strong></font></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">Salvatore Albani, M.D., University of California,
San Diego School of Medicine</i>: $50,000 to study abnormal immune responses specific to
Pauciarticular Juvenile Rheumatoid Arthritis (pJRA). Provides new information about the
cause of this disease and opens the possibility of prevention and new therapies.</font></p>
</dir>
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<td WIDTH="80" VALIGN="top"><p ALIGN="CENTER"><font size="3"><strong>1995-96</strong></font></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">Onsi Kamel, M.D., Stanford University Medical
Center</i>: $50,000 to study the propensity for patients with Rheumatoid Arthritis to
develop lymphomas (cancer) as a result of immunosuppressive therapy used to treat the
arthritis. Study to provide data to allow for more careful monitoring of such treatment,
thereby preventing the development of such lymphomas.</font></p>
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<td WIDTH="80" VALIGN="top"><p ALIGN="CENTER"><strong><font face="Times New Roman"
size="3">1995-96</font></strong></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">William Stohl, M.D., Ph.D., University of
Southern California Medical Center</i>: $50,000 to assess the nature of the body&#146;s
inability to regulate antibody production in patients with Systemic Lupus Erythmatosus
(SLE). With a better knowledge of these mechanisms, specific therapies may be developed to
block autoantibody production and reduce (or eliminate) the manifestations of SLE.</font></p>
</dir>
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<td WIDTH="80" VALIGN="top"><p ALIGN="CENTER"><strong><font face="Times New Roman"
size="3">1994-95</font></strong></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">Tetsuya Gatanaga, Ph.D., University of
California, Irvine: </i>$37,500 to study<i> Cytokines</i>, a class of molecules, one of
which is termed TNF, may be involved in the tissue destruction seen in Rheumatoid
Arthritis. Dr. Gatanaga&#146;s team has isolated a specific molecule that blocks <i>cytokine</i>
activity.</font></p>
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<td WIDTH="80" VALIGN="top"><p ALIGN="CENTER"><strong><font face="Times New Roman"
size="3">1993-94</font></strong></td>
<td WIDTH="520" VALIGN="top"><i><dir>
<p><font face="Times New Roman" size="3">Betty Tsao, Ph.D., University of California, Los
Angeles</i>: $42,000 to develop Immunotherapy by Peptides in Murine Lupus. A study to
isolate and utilize peptides derived from autoantibodies to alter production of
autoantibodies in patients with SLE.</font></p>
</dir>
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<p align="center"><a href="awards.htm"><font face="Times New Roman" size="3"
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<p align="center"><a href="about.htm">[Meet the ANRF]</a> <a href="whatis.htm">[Latest
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href="contact.htm">[Contact Us]</a></p>
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