diff --git a/clients/client-cognito-identity/e2e/CognitoIdentity.ispec.ts b/clients/client-cognito-identity/e2e/CognitoIdentity.ispec.ts
index fdad7741d512..6df6a0a73e33 100644
--- a/clients/client-cognito-identity/e2e/CognitoIdentity.ispec.ts
+++ b/clients/client-cognito-identity/e2e/CognitoIdentity.ispec.ts
@@ -7,7 +7,7 @@ import { expect } from "chai";
 import { CognitoIdentity } from "../index";
 // There will be default values of defaultRegion, credentials, and isBrowser variable in browser tests.
 // Define the values for Node.js tests
-const region: string | undefined = (globalThis as any).defaultRegion || undefined;
+const region: string | undefined = (globalThis as any).defaultRegion || process?.env?.AWS_SMOKE_TEST_REGION;
 const IdentityPoolId =
   (globalThis as any)?.window?.__env__?.AWS_SMOKE_TEST_IDENTITY_POOL_ID ||
   process?.env?.AWS_SMOKE_TEST_IDENTITY_POOL_ID;
diff --git a/clients/client-s3/e2e/S3.ispec.ts b/clients/client-s3/e2e/S3.ispec.ts
index 271eb80eedb7..979ebe0a4d38 100644
--- a/clients/client-s3/e2e/S3.ispec.ts
+++ b/clients/client-s3/e2e/S3.ispec.ts
@@ -12,7 +12,7 @@ chai.use(chaiAsPromised);
 const { expect } = chai;
 // There will be default values of defaultRegion, credentials, and isBrowser variable in browser tests.
 // Define the values for Node.js tests
-const region: string | undefined = (globalThis as any).defaultRegion || undefined;
+const region: string | undefined = (globalThis as any).defaultRegion || process?.env?.AWS_SMOKE_TEST_REGION;
 const credentials: Credentials | undefined = (globalThis as any).credentials || undefined;
 const isBrowser: boolean | undefined = (globalThis as any).isBrowser || false;
 const Bucket = (globalThis as any)?.window?.__env__?.AWS_SMOKE_TEST_BUCKET || process?.env?.AWS_SMOKE_TEST_BUCKET;
diff --git a/package.json b/package.json
index 1c1ca5694b44..76f5e7c0c356 100644
--- a/package.json
+++ b/package.json
@@ -20,6 +20,7 @@
     "test:integration-legacy": "cucumber-js --fail-fast",
     "test:integration": "jest --config jest.config.integ.js --passWithNoTests",
     "test:protocols": "yarn build:protocols && lerna run test --scope '@aws-sdk/aws-*'",
+    "test:e2e": "node ./tests/e2e/index.js",
     "local-publish": "node ./scripts/verdaccio-publish/index.js"
   },
   "repository": {
diff --git a/tests/e2e/get-integ-test-resources.js b/tests/e2e/get-integ-test-resources.js
new file mode 100644
index 000000000000..598dc1e162c6
--- /dev/null
+++ b/tests/e2e/get-integ-test-resources.js
@@ -0,0 +1,23 @@
+const { CloudFormationClient, DescribeStackResourcesCommand } = require("../../clients/client-cloudformation");
+
+exports.getIntegTestResources = async () => {
+  const client = new CloudFormationClient({});
+  const region = await client.config.region();
+
+  const { StackResources: stackResources } = await client.send(
+    new DescribeStackResourcesCommand({ StackName: "IntegTestResourcesStack" })
+  );
+
+  const identityPoolId = stackResources.filter((resource) => resource.ResourceType === "AWS::Cognito::IdentityPool")[0]
+    .PhysicalResourceId;
+
+  const bucketName = stackResources.filter(
+    (resource) => resource.ResourceType === "AWS::S3::Bucket" && resource.LogicalResourceId.indexOf("IntegTest") === 0
+  )[0].PhysicalResourceId;
+
+  return {
+    AWS_SMOKE_TEST_REGION: region,
+    AWS_SMOKE_TEST_IDENTITY_POOL_ID: identityPoolId,
+    AWS_SMOKE_TEST_BUCKET: bucketName,
+  };
+};
diff --git a/tests/e2e/index.js b/tests/e2e/index.js
new file mode 100644
index 000000000000..1e2c4dd01aca
--- /dev/null
+++ b/tests/e2e/index.js
@@ -0,0 +1,13 @@
+const { getIntegTestResources } = require("./get-integ-test-resources");
+const { runE2ETests } = require("./run-e2e-tests");
+
+const run = async () => {
+  try {
+    const integTestResourcesEnv = await getIntegTestResources();
+    await runE2ETests(integTestResourcesEnv);
+  } catch (e) {
+    process.exit(1);
+  }
+};
+
+run();
diff --git a/tests/e2e/run-e2e-tests.js b/tests/e2e/run-e2e-tests.js
new file mode 100644
index 000000000000..f915b7febf7f
--- /dev/null
+++ b/tests/e2e/run-e2e-tests.js
@@ -0,0 +1,49 @@
+const { execSync, spawn } = require("child_process");
+const { join } = require("path");
+const { readFileSync, existsSync } = require("fs");
+const { spawnPromise } = require("./spawn-promise");
+
+const hasE2Etest = (packagePath) => {
+  const path = join(packagePath, "package.json");
+  if (!existsSync(path)) return false;
+  const pkgJson = JSON.parse(readFileSync(path).toString());
+  return Boolean(pkgJson.scripts["test:e2e"]);
+};
+
+exports.runE2ETests = async (resourcesEnv) => {
+  /**
+   * Example output:
+   /path/to/package:@aws-sdk/client-accessanalyzer:1.0.0-gamma.3
+   /path/to/package:@aws-sdk/client-acm-pca:1.0.0-gamma.3
+   /path/to/package:@aws-sdk/client-acm:1.0.0-gamma.3
+   */
+  const changedPackagesRecord = execSync(
+    "./node_modules/.bin/lerna  changed --all --parseable --long --loglevel silent"
+  );
+  // Get array for changed package's path
+  const changedPackages = changedPackagesRecord
+    .toString()
+    .split("\n")
+    .map((record) => record.split(":").slice(0, 2));
+  const packagesToTest = changedPackages.filter((changedPackage) => hasE2Etest(changedPackage[0]));
+  console.log(`packages to run e2e test:
+${packagesToTest.map((package) => package[0]).join("\n")}`);
+  await spawnPromise(
+    "./node_modules/.bin/lerna",
+    [
+      "run",
+      "test:e2e",
+      "--scope",
+      `'{${packagesToTest.map((package) => package[1]).join(",")}}'`, // https://github.com/lerna/lerna/issues/1846#issuecomment-451172783
+      "--concurrency",
+      "1",
+    ],
+    {
+      env: {
+        ...process.env,
+        ...resourcesEnv,
+      },
+      stdio: "inherit",
+    }
+  );
+};
diff --git a/tests/e2e/spawn-promise.js b/tests/e2e/spawn-promise.js
new file mode 100644
index 000000000000..3bfcd83851df
--- /dev/null
+++ b/tests/e2e/spawn-promise.js
@@ -0,0 +1,17 @@
+const { spawn } = require("child_process");
+
+exports.spawnPromise = (command, options, spawnOptions) =>
+  new Promise((resolve, reject) => {
+    const ps = spawn(command, options, {
+      stdio: "inherit",
+      ...spawnOptions,
+    });
+    ps.on("error", reject);
+    ps.on("exit", (code) => {
+      if (code !== 0) {
+        reject(new Error(`Unexpected exit code [${code}]`));
+      } else {
+        resolve();
+      }
+    });
+  });