diff --git a/awswrangler/neptune/neptune.py b/awswrangler/neptune/neptune.py
index b7a6e48fb..790a12c98 100644
--- a/awswrangler/neptune/neptune.py
+++ b/awswrangler/neptune/neptune.py
@@ -290,7 +290,7 @@ def _set_properties(g: GraphTraversalSource, use_header_cardinality: bool, row:
         if column not in ["~id", "~label", "~to", "~from"]:
             # If the column header is specifying the cardinality then use it
             if use_header_cardinality:
-                if column.lower().find("(single)") > 0:
+                if column.lower().find("(single)") > 0 and pd.notna(value):
                     g = g.property(Cardinality.single, _get_column_name(column), value)
                 else:
                     g = _expand_properties(g, _get_column_name(column), value)
@@ -305,7 +305,7 @@ def _expand_properties(g: GraphTraversalSource, column: str, value: Any) -> Grap
     if isinstance(value, list) and len(value) > 0:
         for item in value:
             g = g.property(Cardinality.set_, column, item)
-    else:
+    elif pd.notna(value):
         g = g.property(Cardinality.set_, column, value)
     return g
 
diff --git a/tests/test_neptune.py b/tests/test_neptune.py
index 29af98bb4..92c05e206 100644
--- a/tests/test_neptune.py
+++ b/tests/test_neptune.py
@@ -4,6 +4,7 @@
 import uuid
 from typing import Any, Dict
 
+import numpy as np
 import pandas as pd
 import pytest  # type: ignore
 from gremlin_python.process.traversal import Direction, T
@@ -169,6 +170,33 @@ def test_sparql_query(neptune_endpoint, neptune_port) -> Dict[str, Any]:
     assert df.shape == (2, 3)
 
 
+def test_gremlin_write_different_cols(neptune_endpoint, neptune_port) -> Dict[str, Any]:
+    client = wr.neptune.connect(neptune_endpoint, neptune_port, iam_enabled=False)
+    id = uuid.uuid4()
+    wr.neptune.execute_gremlin(client, f"g.addV().property(T.id, '{str(id)}')")
+
+    data = [_create_dummy_vertex(), _create_dummy_vertex()]
+    del data[1]["str"]
+    data[1]["int"] = np.nan
+    df = pd.DataFrame(data)
+    res = wr.neptune.to_property_graph(client, df)
+    assert res
+
+    data = [_create_dummy_edge(), _create_dummy_edge()]
+    del data[1]["str"]
+    data[1]["int"] = np.nan
+    df = pd.DataFrame(data)
+    res = wr.neptune.to_property_graph(client, df)
+    assert res
+
+    data = [{"~id": id, "age(single)": 50, "name": "foo"}, {"~id": id, "age(single)": 55}, {"~id": id, "name": "foo"}]
+    df = pd.DataFrame(data)
+    res = wr.neptune.to_property_graph(client, df)
+    res = wr.neptune.execute_gremlin(client, f"g.V('{id}').valueMap().with(WithOptions.tokens)")
+    saved_row = res.iloc[0]
+    assert saved_row["age"] == 55
+
+
 def test_gremlin_write_updates(neptune_endpoint, neptune_port) -> Dict[str, Any]:
     client = wr.neptune.connect(neptune_endpoint, neptune_port, iam_enabled=False)
     id = uuid.uuid4()
@@ -191,12 +219,14 @@ def test_gremlin_write_updates(neptune_endpoint, neptune_port) -> Dict[str, Any]
     res = wr.neptune.execute_gremlin(client, f"g.V('{id}').valueMap().with(WithOptions.tokens)")
     saved_row = res.iloc[0]
     assert saved_row["age"] == 55
-    assert saved_row["name"] == ["foo", "bar"]
+    assert "foo" in saved_row["name"]
+    assert "bar" in saved_row["name"]
     res = wr.neptune.to_property_graph(client, df, use_header_cardinality=False)
     res = wr.neptune.execute_gremlin(client, f"g.V('{id}').valueMap().with(WithOptions.tokens)")
     saved_row = res.iloc[0]
     assert saved_row["age(single)"] == 55
-    assert saved_row["name"] == ["foo", "bar"]
+    assert "foo" in saved_row["name"]
+    assert "bar" in saved_row["name"]
 
 
 def test_gremlin_write_vertices(neptune_endpoint, neptune_port) -> Dict[str, Any]:
@@ -298,6 +328,22 @@ def test_gremlin_write_edges(neptune_endpoint, neptune_port) -> Dict[str, Any]:
     assert batch_cnt_df.iloc[0][0] == final_cnt_df.iloc[0][0] + 50
 
 
+def test_sparql_write_different_cols(neptune_endpoint, neptune_port) -> Dict[str, Any]:
+    client = wr.neptune.connect(neptune_endpoint, neptune_port, iam_enabled=False)
+
+    data = [_create_dummy_triple(), _create_dummy_triple()]
+    del data[1]["o"]
+    df = pd.DataFrame(data)
+    res = wr.neptune.to_rdf_graph(client, df)
+    assert res
+
+    data = [_create_dummy_quad(), _create_dummy_quad()]
+    del data[1]["o"]
+    df = pd.DataFrame(data)
+    res = wr.neptune.to_rdf_graph(client, df)
+    assert res
+
+
 def test_sparql_write_triples(neptune_endpoint, neptune_port) -> Dict[str, Any]:
     client = wr.neptune.connect(neptune_endpoint, neptune_port, iam_enabled=False)
     initial_df = wr.neptune.execute_sparql(client, "SELECT ?p ?o WHERE { <foo> ?p ?o .}")