diff --git a/src/sagemaker/cli/compatibility/v2/ast_transformer.py b/src/sagemaker/cli/compatibility/v2/ast_transformer.py
index 6b63fd61a1..c39fe9f543 100644
--- a/src/sagemaker/cli/compatibility/v2/ast_transformer.py
+++ b/src/sagemaker/cli/compatibility/v2/ast_transformer.py
@@ -37,6 +37,7 @@
     modifiers.training_input.TrainingInputConstructorRefactor(),
     modifiers.training_input.ShuffleConfigModuleRenamer(),
     modifiers.serde.SerdeConstructorRenamer(),
+    modifiers.serde.SerdeKeywordRemover(),
     modifiers.image_uris.ImageURIRetrieveRefactor(),
 ]
 
diff --git a/src/sagemaker/cli/compatibility/v2/modifiers/serde.py b/src/sagemaker/cli/compatibility/v2/modifiers/serde.py
index 59b7a2c19d..83a173c392 100644
--- a/src/sagemaker/cli/compatibility/v2/modifiers/serde.py
+++ b/src/sagemaker/cli/compatibility/v2/modifiers/serde.py
@@ -157,6 +157,48 @@ def modify_node(self, node):
         )
 
 
+class SerdeKeywordRemover(Modifier):
+    """A class to remove Serde-related keyword arguments from call expressions."""
+
+    def node_should_be_modified(self, node):
+        """Checks if the ``ast.Call`` node uses deprecated keywords.
+
+        In particular, this function checks if:
+
+        - The ``ast.Call`` represents the ``create_model`` method.
+        - Either the serializer or deserializer keywords are used.
+
+        Args:
+            node (ast.Call): a node that represents a function call. For more,
+                see https://docs.python.org/3/library/ast.html#abstract-grammar.
+
+        Returns:
+            bool: If the ``ast.Call`` contains keywords that should be removed.
+        """
+        if not isinstance(node.func, ast.Attribute) or node.func.attr != "create_model":
+            return False
+        return any(keyword.arg in {"serializer", "deserializer"} for keyword in node.keywords)
+
+    def modify_node(self, node):
+        """Removes the serializer and deserializer keywords, as applicable.
+
+        Args:
+            node (ast.Call): a node that represents a ``create_model`` call.
+
+        Returns:
+            ast.Call: the node that represents a ``create_model`` call without
+                serializer or deserializers keywords.
+        """
+        i = 0
+        while i < len(node.keywords):
+            keyword = node.keywords[i]
+            if keyword.arg in {"serializer", "deserializer"}:
+                node.keywords.pop(i)
+            else:
+                i += 1
+        return node
+
+
 class SerdeObjectRenamer(Modifier):
     """A class to rename SerDe objects imported from ``sagemaker.predictor``."""
 
diff --git a/tests/unit/sagemaker/cli/compatibility/v2/modifiers/test_serde.py b/tests/unit/sagemaker/cli/compatibility/v2/modifiers/test_serde.py
index 11da4fde6d..c71468bf41 100644
--- a/tests/unit/sagemaker/cli/compatibility/v2/modifiers/test_serde.py
+++ b/tests/unit/sagemaker/cli/compatibility/v2/modifiers/test_serde.py
@@ -346,3 +346,42 @@ def test_deserializer_module_modify_node(src, expected):
     node = pasta.parse(src)
     modified_node = modifier.modify_node(node)
     assert expected == pasta.dump(modified_node)
+
+
+@pytest.mark.parametrize(
+    "src, expected",
+    [
+        ('estimator.create_model(entry_point="inference.py")', False),
+        ("estimator.create_model(serializer=CSVSerializer())", True),
+        ("estimator.create_model(deserializer=CSVDeserializer())", True),
+        (
+            "estimator.create_model(serializer=CSVSerializer(), deserializer=CSVDeserializer())",
+            True,
+        ),
+        ("estimator.deploy(serializer=CSVSerializer())", False),
+    ],
+)
+def test_create_model_call_node_should_be_modified(src, expected):
+    modifier = serde.SerdeKeywordRemover()
+    node = ast_call(src)
+    assert modifier.node_should_be_modified(node) is expected
+
+
+@pytest.mark.parametrize(
+    "src, expected",
+    [
+        (
+            'estimator.create_model(entry_point="inference.py", serializer=CSVSerializer())',
+            'estimator.create_model(entry_point="inference.py")',
+        ),
+        (
+            'estimator.create_model(entry_point="inference.py", deserializer=CSVDeserializer())',
+            'estimator.create_model(entry_point="inference.py")',
+        ),
+    ],
+)
+def test_create_model_call_modify_node(src, expected):
+    modifier = serde.SerdeKeywordRemover()
+    node = ast_call(src)
+    modified_node = modifier.modify_node(node)
+    assert expected == pasta.dump(modified_node)