diff --git a/Makefile b/Makefile
index 7ef33bcef..709820279 100755
--- a/Makefile
+++ b/Makefile
@@ -1,54 +1,17 @@
-NAME=samtranslator27
-PYTHON_VERSION=2.7.14
-CODE_COVERAGE=95
-PYENV := $(shell command -v pyenv 2> /dev/null)
-
 target:
 	$(info ${HELP_MESSAGE})
 	@exit 0
-
-# Make sure that pyenv is configured properly and that we can use it in our setup target.
-validation:
-ifndef PYENV
-    $(error "make sure pyenv is accessible in your path, (usually by adding to PATH variable in bash_profile, zshrc, or other locations based on your platform) See: https://github.com/pyenv/pyenv#installation for the installation insructions.")
-endif
-ifndef PYENV_SHELL
-	$(error "Add 'pyenv init' to your shell to enable shims and autocompletion, (usually by adding to your bash_profile, zshrc, or other locations based on your platform)")
-endif
-ifndef PYENV_VIRTUALENV_INIT
-	$(error "Add 'pyenv virtualenv-init' to your shell to enable shims and autocompletion, (usually by adding to your bash_profile, zshrc, or other locations based on your platform)")
-endif
-
-install:
-	$(info [*] Install pyenv using https://github.com/pyenv/pyenv-installer/raw/master/bin/pyenv-installer...)
-	@curl -L https://github.com/pyenv/pyenv-installer/raw/master/bin/pyenv-installer 2> /dev/null | bash
-
-setup: validation
-	$(info [*] Download and install python $(PYTHON_VERSION)...)
-	@pyenv install $(PYTHON_VERSION)
-	@pyenv local $(PYTHON_VERSION) 
-	$(info [*] Create virtualenv $(NAME) using python $(PYTHON_VERSION)...)
-	@pyenv virtualenv $(PYTHON_VERSION) $(NAME)
-	@$(MAKE) activate
-	
-activate:
-	$(info [*] Activate virtualenv $(NAME)...)
-	$(shell eval "$$(pyenv init -)" && eval "$$(pyenv virtualenv-init -)" && pyenv activate $(NAME) && pyenv local $(NAME))
 	
 init:
-	$(info [*] Install requirements...)
-	@pip install -r requirements/dev.txt -r requirements/base.txt
+	pip install -e '.[dev]'
 
 test:
-	$(info [*] Run the unit test with minimum code coverage of $(CODE_COVERAGE)%...)
-	@pytest --cov samtranslator --cov-report term-missing --cov-fail-under $(CODE_COVERAGE) tests
+	pytest --cov samtranslator --cov-report term-missing --cov-fail-under 95 tests
 
 black:
-	rm -f tests/*.pyc samtranslator/*.pyc
 	black setup.py samtranslator/* tests/* bin/*
 
 black-check:
-	rm -f tests/*.pyc samtranslator/*.pyc
 	black --check setup.py samtranslator/* tests/* bin/*
 
 # Command to run everytime you make changes to verify everything works
@@ -62,9 +25,6 @@ define HELP_MESSAGE
 Usage: $ make [TARGETS]
 
 TARGETS
-	install     Install pyenv using the pyenv-installer.
-	setup       Download, install and activate a virtualenv for this project.
-	activate    Activate the virtual environment for this project.
 	init        Initialize and install the requirements and dev-requirements for this project.
 	test        Run the Unit tests.
 	dev         Run all development tests after a change.