Cancer

Francisco García edited this page Jan 26, 2015 · 7 revisions
Clone this wiki locally

Babelomics includes two approaches to analyse cancer genomic sequences:

  • [OncodriveFM](Tutorial OncodriveFM) is a method to identify cancer drivers from cancer somatic mutations in a cohort of tumors. It computes the bias towards the accumulation of variants with high functional impact (FM bias).

  • [OncodriveClust](Tutorial OncodriveClust) is a method to identify genes in which mutations accumulate within specific regions of the protein, which denote events selected by the tumour. It computes a score measuring the mutation clustering of a gene across the protein sequence and compares it with a background model.