diff --git a/.bazelrc b/.bazelrc
index 9a3c42c..4544b7b 100644
--- a/.bazelrc
+++ b/.bazelrc
@@ -18,25 +18,25 @@ build --action_env=CXX=clang++
 
 # LibFuzzer + ASAN
 build:asan-libfuzzer --//fuzzing:cc_engine=//fuzzing/engines:libfuzzer
-build:asan-libfuzzer --//fuzzing:cc_engine_instrumentation=libfuzzer
-build:asan-libfuzzer --//fuzzing:cc_engine_sanitizer=asan
+build:asan-libfuzzer --@rules_fuzzing//fuzzing:cc_engine_instrumentation=libfuzzer
+build:asan-libfuzzer --@rules_fuzzing//fuzzing:cc_engine_sanitizer=asan
 
 # LibFuzzer + MSAN
 build:msan-libfuzzer --//fuzzing:cc_engine=//fuzzing/engines:libfuzzer
-build:msan-libfuzzer --//fuzzing:cc_engine_instrumentation=libfuzzer
-build:msan-libfuzzer --//fuzzing:cc_engine_sanitizer=msan
+build:msan-libfuzzer --@rules_fuzzing//fuzzing:cc_engine_instrumentation=libfuzzer
+build:msan-libfuzzer --@rules_fuzzing//fuzzing:cc_engine_sanitizer=msan
 
 # LibFuzzer + MSAN (reproduction mode)
 build:msan-libfuzzer-repro --//fuzzing:cc_engine=//fuzzing/engines:libfuzzer
-build:msan-libfuzzer-repro --//fuzzing:cc_engine_instrumentation=libfuzzer
-build:msan-libfuzzer-repro --//fuzzing:cc_engine_sanitizer=msan-origin-tracking
+build:msan-libfuzzer-repro --@rules_fuzzing//fuzzing:cc_engine_instrumentation=libfuzzer
+build:msan-libfuzzer-repro --@rules_fuzzing//fuzzing:cc_engine_sanitizer=msan-origin-tracking
 
 # Honggfuzz + ASAN
 build:asan-honggfuzz --//fuzzing:cc_engine=//fuzzing/engines:honggfuzz
-build:asan-honggfuzz --//fuzzing:cc_engine_instrumentation=honggfuzz
-build:asan-honggfuzz --//fuzzing:cc_engine_sanitizer=asan
+build:asan-honggfuzz --@rules_fuzzing//fuzzing:cc_engine_instrumentation=honggfuzz
+build:asan-honggfuzz --@rules_fuzzing//fuzzing:cc_engine_sanitizer=asan
 
 # Honggfuzz + MSAN
 build:msan-honggfuzz --//fuzzing:cc_engine=//fuzzing/engines:honggfuzz
-build:msan-honggfuzz --//fuzzing:cc_engine_instrumentation=honggfuzz
-build:msan-honggfuzz --//fuzzing:cc_engine_sanitizer=msan
+build:msan-honggfuzz --@rules_fuzzing//fuzzing:cc_engine_instrumentation=honggfuzz
+build:msan-honggfuzz --@rules_fuzzing//fuzzing:cc_engine_sanitizer=msan
diff --git a/README.md b/README.md
index 3dfef84..ebdbddc 100644
--- a/README.md
+++ b/README.md
@@ -123,7 +123,7 @@ The project is still under active development, so you many need to change the `u
 
 ### Configuring the .bazelrc file
 
-Each fuzz test is built with a fuzzing engine and instrumentation specified in three build settings, available as flags on the Bazel command line:
+Each fuzz test is built with a fuzzing engine and instrumentation specified in a number of build settings, available as flags on the Bazel command line. The most common are:
 
 * `--@rules_fuzzing//fuzzing:cc_engine` points to the `cc_fuzzing_engine` target of the fuzzing engine to use.
 * `--@rules_fuzzing//fuzzing:cc_engine_instrumentation` specifies the compiler instrumentation to use (for example, libFuzzer or Honggfuzz).
diff --git a/fuzzing/BUILD b/fuzzing/BUILD
index 94872a4..d6c3110 100644
--- a/fuzzing/BUILD
+++ b/fuzzing/BUILD
@@ -12,7 +12,7 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-load("@bazel_skylib//rules:common_settings.bzl", "string_flag")
+load("@bazel_skylib//rules:common_settings.bzl", "bool_flag", "string_flag")
 
 label_flag(
     name = "cc_engine",
@@ -50,6 +50,16 @@ string_flag(
     visibility = ["//visibility:public"],
 )
 
+# If set, define the FUZZING_BUILD_MODE_UNSAFE_FOR_PRODUCTION macro
+# during compilation.
+#
+# See https://llvm.org/docs/LibFuzzer.html#fuzzer-friendly-build-mode
+bool_flag(
+    name = "cc_fuzzing_build_mode",
+    build_setting_default = True,
+    visibility = ["//visibility:public"],
+)
+
 exports_files([
     "cc_deps.bzl",
     "instrum_opts.bzl",
diff --git a/fuzzing/instrum_opts.bzl b/fuzzing/instrum_opts.bzl
index f6fb4d6..e0d206d 100644
--- a/fuzzing/instrum_opts.bzl
+++ b/fuzzing/instrum_opts.bzl
@@ -48,8 +48,10 @@ def instrumentation_opts(copts = [], linkopts = []):
         linkopts = linkopts,
     )
 
-# Base instrumentation applied to all fuzz test executables.
-base_opts = instrumentation_opts(
+# Instrumentation applied to all fuzz test executables when built in fuzzing
+# mode. This mode is controlled by the `//fuzzing:cc_fuzzing_build_mode` config
+# flag.
+fuzzing_build_opts = instrumentation_opts(
     copts = ["-DFUZZING_BUILD_MODE_UNSAFE_FOR_PRODUCTION"],
 )
 
diff --git a/fuzzing/private/instrument.bzl b/fuzzing/private/instrument.bzl
index 543b0dc..9af7e33 100644
--- a/fuzzing/private/instrument.bzl
+++ b/fuzzing/private/instrument.bzl
@@ -16,7 +16,7 @@
 
 load(
     "//fuzzing:instrum_opts.bzl",
-    "base_opts",
+    "fuzzing_build_opts",
     "fuzzing_engine_opts",
     "instrumentation_opts",
     "sanitizer_opts",
@@ -33,15 +33,18 @@ def _fuzzing_binary_transition_impl(settings, attr):
         copts = settings["//command_line_option:copt"],
         linkopts = settings["//command_line_option:linkopt"],
     )
-    opts = _merge_opts(opts, base_opts)
 
-    engine = settings["//fuzzing:cc_engine_instrumentation"]
+    is_fuzzing_build_mode = settings["@rules_fuzzing//fuzzing:cc_fuzzing_build_mode"]
+    if is_fuzzing_build_mode:
+        opts = _merge_opts(opts, fuzzing_build_opts)
+
+    engine = settings["@rules_fuzzing//fuzzing:cc_engine_instrumentation"]
     if engine in fuzzing_engine_opts:
         opts = _merge_opts(opts, fuzzing_engine_opts[engine])
     else:
         fail("unsupported engine instrumentation '%s'" % engine)
 
-    sanitizer = settings["//fuzzing:cc_engine_sanitizer"]
+    sanitizer = settings["@rules_fuzzing//fuzzing:cc_engine_sanitizer"]
     if sanitizer in sanitizer_opts:
         opts = _merge_opts(opts, sanitizer_opts[sanitizer])
     else:
@@ -63,8 +66,9 @@ def _fuzzing_binary_transition_impl(settings, attr):
 fuzzing_binary_transition = transition(
     implementation = _fuzzing_binary_transition_impl,
     inputs = [
-        "//fuzzing:cc_engine_instrumentation",
-        "//fuzzing:cc_engine_sanitizer",
+        "@rules_fuzzing//fuzzing:cc_engine_instrumentation",
+        "@rules_fuzzing//fuzzing:cc_engine_sanitizer",
+        "@rules_fuzzing//fuzzing:cc_fuzzing_build_mode",
         "//command_line_option:copt",
         "//command_line_option:linkopt",
     ],