diff --git a/data/variants.ts b/data/variants.ts
new file mode 100644
index 0000000..94f67e1
--- /dev/null
+++ b/data/variants.ts
@@ -0,0 +1,456 @@
+import { NOTATION_TO_TYPES } from '../src/constants';
+
+const standardVariants = {
+    'EGFR:e.20_21ins': {
+        break1Start: {
+            '@class': 'ExonicPosition',
+            pos: 20,
+            prefix: 'e',
+        },
+        break1Repr: 'e.20',
+        break2Start: {
+            '@class': 'ExonicPosition',
+            pos: 21,
+            prefix: 'e',
+        },
+        break2Repr: 'e.21',
+        prefix: 'e',
+        reference1: 'EGFR',
+        type: NOTATION_TO_TYPES.ins,
+    },
+    'KRAS:p.G12D': {
+        break1Start: {
+            '@class': 'ProteinPosition',
+            pos: 12,
+            prefix: 'p',
+            refAA: 'G',
+        },
+        break1Repr: 'p.G12',
+        prefix: 'p',
+        reference1: 'KRAS',
+        type: NOTATION_TO_TYPES.mis,
+        untemplatedSeq: 'D',
+    },
+};
+
+// Actual fusion variant with legacy notation (KBDEV-974)
+const legacyNomenclatureFusionVariants = {
+    '(ATP1B1,NRG1):fusion(g.169080736,g.32453346)': {
+        reference1: 'ATP1B1',
+        reference2: 'NRG1',
+        multiFeature: true,
+        type: NOTATION_TO_TYPES.fusion,
+        break1Start: {
+            '@class': 'GenomicPosition',
+            pos: 169080736,
+            prefix: 'g',
+        },
+        break1Repr: 'g.169080736',
+        break2Start: {
+            '@class': 'GenomicPosition',
+            pos: 32453346,
+            prefix: 'g',
+        },
+        break2Repr: 'g.32453346',
+        noFeatures: false,
+        prefix: 'g',
+    },
+    '(ENST00000357447,ENST00000371953):fusion(c.1118,c.165)': {
+        reference1: 'ENST00000357447',
+        reference2: 'ENST00000371953',
+        multiFeature: true,
+        type: NOTATION_TO_TYPES.fusion,
+        break1Start: {
+            '@class': 'CdsPosition',
+            pos: 1118,
+            prefix: 'c',
+            offset: 0,
+        },
+        break1Repr: 'c.1118',
+        break2Start: {
+            '@class': 'CdsPosition',
+            pos: 165,
+            prefix: 'c',
+            offset: 0,
+        },
+        break2Repr: 'c.165',
+        noFeatures: false,
+        prefix: 'c',
+    },
+    '(COL1A1,PDGFB):fusion(r.2354,r.852)': {
+        reference1: 'COL1A1',
+        reference2: 'PDGFB',
+        multiFeature: true,
+        type: NOTATION_TO_TYPES.fusion,
+        break1Start: {
+            '@class': 'RnaPosition',
+            pos: 2354,
+            prefix: 'r',
+            offset: 0,
+        },
+        break1Repr: 'r.2354',
+        break2Start: {
+            '@class': 'RnaPosition',
+            pos: 852,
+            prefix: 'r',
+            offset: 0,
+        },
+        break2Repr: 'r.852',
+        noFeatures: false,
+        prefix: 'r',
+    },
+    '(CLTC,ALK):fusion(e.30,e.20)': {
+        reference1: 'CLTC',
+        reference2: 'ALK',
+        multiFeature: true,
+        type: NOTATION_TO_TYPES.fusion,
+        break1Start: {
+            '@class': 'ExonicPosition',
+            pos: 30,
+            prefix: 'e',
+        },
+        break1Repr: 'e.30',
+        break2Start: {
+            '@class': 'ExonicPosition',
+            pos: 20,
+            prefix: 'e',
+        },
+        break2Repr: 'e.20',
+        noFeatures: false,
+        prefix: 'e',
+    },
+    '(ZNF532,NUTM1):fusion(p.?4,e.2)': {
+        reference1: 'ZNF532',
+        reference2: 'NUTM1',
+        multiFeature: true,
+        type: NOTATION_TO_TYPES.fusion,
+        break1Start: {
+            '@class': 'ProteinPosition',
+            pos: 4,
+            prefix: 'p',
+            longRefAA: null,
+            refAA: null,
+        },
+        break1Repr: 'p.?4',
+        break2Start: {
+            '@class': 'ExonicPosition',
+            pos: 2,
+            prefix: 'e',
+        },
+        break2Repr: 'e.2',
+        noFeatures: false,
+        prefix: null,
+    },
+    '(CDH1,LARS):fusion(i.2,e.17)': {
+        reference1: 'CDH1',
+        reference2: 'LARS',
+        multiFeature: true,
+        type: NOTATION_TO_TYPES.fusion,
+        break1Start: {
+            '@class': 'IntronicPosition',
+            pos: 2,
+            prefix: 'i',
+        },
+        break1Repr: 'i.2',
+        break2Start: {
+            '@class': 'ExonicPosition',
+            pos: 17,
+            prefix: 'e',
+        },
+        break2Repr: 'e.17',
+        noFeatures: false,
+        prefix: null,
+    },
+    '(chr3,BRAF):fusion(y.p26.3,e.4)': {
+        reference1: 'chr3',
+        reference2: 'BRAF',
+        multiFeature: true,
+        type: NOTATION_TO_TYPES.fusion,
+        break1Start: {
+            arm: 'p',
+            majorBand: 26,
+            minorBand: 3,
+            '@class': 'CytobandPosition',
+            prefix: 'y',
+        },
+        break1Repr: 'y.p26.3',
+        break2Start: {
+            '@class': 'ExonicPosition',
+            pos: 4,
+            prefix: 'e',
+        },
+        break2Repr: 'e.4',
+        noFeatures: false,
+        prefix: null,
+    },
+};
+
+// New fusion nomenclature (KBDEV-974)
+const newNomenclatureFusionVariants = {
+    'ATP1B1:g.?_169080736::NRG1:g.32453346_?': {
+        reference1: 'ATP1B1',
+        reference2: 'NRG1',
+        multiFeature: true,
+        type: NOTATION_TO_TYPES.fusion,
+        break1Start: {
+            '@class': 'GenomicPosition',
+            pos: null,
+            prefix: 'g',
+        },
+        break1End: {
+            '@class': 'GenomicPosition',
+            pos: 169080736,
+            prefix: 'g',
+        },
+        break1Repr: 'g.?_169080736',
+        break2End: {
+            '@class': 'GenomicPosition',
+            pos: null,
+            prefix: 'g',
+        },
+        break2Start: {
+            '@class': 'GenomicPosition',
+            pos: 32453346,
+            prefix: 'g',
+        },
+        break2Repr: 'g.32453346_?',
+        noFeatures: false,
+        prefix: 'g',
+    },
+    'ENST00000357447:c.?_1118::ENST00000371953:c.165_?': {
+        reference1: 'ENST00000357447',
+        reference2: 'ENST00000371953',
+        multiFeature: true,
+        type: 'fusion',
+        break1Start: {
+            '@class': 'CdsPosition',
+            pos: null,
+            prefix: 'c',
+            offset: 0,
+        },
+        break1End: {
+            '@class': 'CdsPosition',
+            pos: 1118,
+            prefix: 'c',
+            offset: 0,
+        },
+        break1Repr: 'c.?_1118',
+        break2End: {
+            '@class': 'CdsPosition',
+            pos: null,
+            prefix: 'c',
+            offset: 0,
+        },
+        break2Start: {
+            '@class': 'CdsPosition',
+            pos: 165,
+            prefix: 'c',
+            offset: 0,
+        },
+        break2Repr: 'c.165_?',
+        noFeatures: false,
+        prefix: 'c',
+    },
+    'COL1A1:r.?_2354::PDGFB:r.852_?': {
+        reference1: 'COL1A1',
+        reference2: 'PDGFB',
+        multiFeature: true,
+        type: 'fusion',
+        break1Start: {
+            '@class': 'RnaPosition',
+            pos: null,
+            prefix: 'r',
+            offset: 0,
+        },
+        break1End: {
+            '@class': 'RnaPosition',
+            pos: 2354,
+            prefix: 'r',
+            offset: 0,
+        },
+        break1Repr: 'r.?_2354',
+        break2End: {
+            '@class': 'RnaPosition',
+            pos: null,
+            prefix: 'r',
+            offset: 0,
+        },
+        break2Start: {
+            '@class': 'RnaPosition',
+            pos: 852,
+            prefix: 'r',
+            offset: 0,
+        },
+        break2Repr: 'r.852_?',
+        noFeatures: false,
+        prefix: 'r',
+    },
+    'CLTC:e.?_30::ALK:e.20_?': {
+        reference1: 'CLTC',
+        reference2: 'ALK',
+        multiFeature: true,
+        type: 'fusion',
+        break1Start: {
+            '@class': 'ExonicPosition',
+            pos: null,
+            prefix: 'e',
+        },
+        break1End: {
+            '@class': 'ExonicPosition',
+            pos: 30,
+            prefix: 'e',
+        },
+        break1Repr: 'e.?_30',
+        break2End: {
+            '@class': 'ExonicPosition',
+            pos: null,
+            prefix: 'e',
+        },
+        break2Start: {
+            '@class': 'ExonicPosition',
+            pos: 20,
+            prefix: 'e',
+        },
+        break2Repr: 'e.20_?',
+        noFeatures: false,
+        prefix: 'e',
+    },
+    'ZNF532:p.??_?4::NUTM1:e.2_?': {
+        reference1: 'ZNF532',
+        reference2: 'NUTM1',
+        multiFeature: true,
+        type: 'fusion',
+        break1Start: {
+            '@class': 'ProteinPosition',
+            pos: null,
+            prefix: 'p',
+            longRefAA: null,
+            refAA: null,
+        },
+        break1End: {
+            '@class': 'ProteinPosition',
+            pos: 4,
+            prefix: 'p',
+            longRefAA: null,
+            refAA: null,
+        },
+        break1Repr: 'p.??_?4',
+        break2End: {
+            '@class': 'ExonicPosition',
+            pos: null,
+            prefix: 'e',
+        },
+        break2Start: {
+            '@class': 'ExonicPosition',
+            pos: 2,
+            prefix: 'e',
+        },
+        break2Repr: 'e.2_?',
+        noFeatures: false,
+        prefix: null,
+    },
+    'CDH1:i.?_2::LARS:e.17_?': {
+        reference1: 'CDH1',
+        reference2: 'LARS',
+        multiFeature: true,
+        type: 'fusion',
+        break1Start: {
+            '@class': 'IntronicPosition',
+            pos: null,
+            prefix: 'i',
+        },
+        break1End: {
+            '@class': 'IntronicPosition',
+            pos: 2,
+            prefix: 'i',
+        },
+        break1Repr: 'i.?_2',
+        break2End: {
+            '@class': 'ExonicPosition',
+            pos: null,
+            prefix: 'e',
+        },
+        break2Start: {
+            '@class': 'ExonicPosition',
+            pos: 17,
+            prefix: 'e',
+        },
+        break2Repr: 'e.17_?',
+        noFeatures: false,
+        prefix: null,
+    },
+    'chr3:y.p_p26.3::BRAF:e.4_?': {
+        reference1: 'chr3',
+        reference2: 'BRAF',
+        multiFeature: true,
+        type: 'fusion',
+        break1Start: {
+            arm: 'p',
+            '@class': 'CytobandPosition',
+            prefix: 'y',
+        },
+        break1End: {
+            arm: 'p',
+            majorBand: 26,
+            minorBand: 3,
+            '@class': 'CytobandPosition',
+            prefix: 'y',
+        },
+        break1Repr: 'y.p_p26.3',
+        break2End: {
+            '@class': 'ExonicPosition',
+            pos: null,
+            prefix: 'e',
+        },
+        break2Start: {
+            '@class': 'ExonicPosition',
+            pos: 4,
+            prefix: 'e',
+        },
+        break2Repr: 'e.4_?',
+        noFeatures: false,
+        prefix: null,
+    },
+    'EPCAM:r.?_555::GUAUGAUUUUUUAAUAA::MSH2:r.212_?': {
+        reference1: 'EPCAM',
+        reference2: 'MSH2',
+        multiFeature: true,
+        type: 'fusion',
+        break1Start: {
+            '@class': 'RnaPosition',
+            pos: null,
+            prefix: 'r',
+            offset: 0,
+        },
+        break1End: {
+            '@class': 'RnaPosition',
+            pos: 555,
+            prefix: 'r',
+            offset: 0,
+        },
+        break1Repr: 'r.?_555',
+        break2End: {
+            '@class': 'RnaPosition',
+            pos: null,
+            prefix: 'r',
+            offset: 0,
+        },
+        break2Start: {
+            '@class': 'RnaPosition',
+            pos: 212,
+            prefix: 'r',
+            offset: 0,
+        },
+        break2Repr: 'r.212_?',
+        untemplatedSeq: 'GUAUGAUUUUUUAAUAA',
+        untemplatedSeqSize: 17,
+        noFeatures: false,
+        prefix: 'r',
+    },
+};
+
+export default {
+    legacyNomenclatureFusionVariants,
+    newNomenclatureFusionVariants,
+    standardVariants,
+};
diff --git a/package-lock.json b/package-lock.json
index 7185fb3..c12946a 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -1,12 +1,12 @@
 {
   "name": "@bcgsc-pori/graphkb-parser",
-  "version": "2.0.0",
+  "version": "2.1.0",
   "lockfileVersion": 2,
   "requires": true,
   "packages": {
     "": {
       "name": "@bcgsc-pori/graphkb-parser",
-      "version": "1.1.3",
+      "version": "2.1.0",
       "license": "GPL-3.0",
       "dependencies": {
         "json-cycle": "^1.3.0"
@@ -85,9 +85,9 @@
       }
     },
     "node_modules/@babel/core/node_modules/semver": {
-      "version": "6.3.0",
-      "resolved": "https://registry.npmjs.org/semver/-/semver-6.3.0.tgz",
-      "integrity": "sha512-b39TBaTSfV6yBrapU89p5fKekE2m/NwnDocOVruQFS1/veMgdzuPcnOM34M6CwxW8jH/lxEa5rBoDeUwu5HHTw==",
+      "version": "6.3.1",
+      "resolved": "https://registry.npmjs.org/semver/-/semver-6.3.1.tgz",
+      "integrity": "sha512-BR7VvDCVHO+q2xBEWskxS6DJE1qRnb7DxzUrogb71CWoSficBxYsiAGd+Kl0mmq/MprG9yArRkyrQxTO6XjMzA==",
       "dev": true,
       "bin": {
         "semver": "bin/semver.js"
@@ -151,9 +151,9 @@
       }
     },
     "node_modules/@babel/helper-compilation-targets/node_modules/semver": {
-      "version": "6.3.0",
-      "resolved": "https://registry.npmjs.org/semver/-/semver-6.3.0.tgz",
-      "integrity": "sha512-b39TBaTSfV6yBrapU89p5fKekE2m/NwnDocOVruQFS1/veMgdzuPcnOM34M6CwxW8jH/lxEa5rBoDeUwu5HHTw==",
+      "version": "6.3.1",
+      "resolved": "https://registry.npmjs.org/semver/-/semver-6.3.1.tgz",
+      "integrity": "sha512-BR7VvDCVHO+q2xBEWskxS6DJE1qRnb7DxzUrogb71CWoSficBxYsiAGd+Kl0mmq/MprG9yArRkyrQxTO6XjMzA==",
       "dev": true,
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         "semver": "bin/semver.js"
@@ -216,9 +216,9 @@
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     },
     "node_modules/@babel/helper-define-polyfill-provider/node_modules/semver": {
-      "version": "6.3.0",
-      "resolved": "https://registry.npmjs.org/semver/-/semver-6.3.0.tgz",
-      "integrity": "sha512-b39TBaTSfV6yBrapU89p5fKekE2m/NwnDocOVruQFS1/veMgdzuPcnOM34M6CwxW8jH/lxEa5rBoDeUwu5HHTw==",
+      "version": "6.3.1",
+      "resolved": "https://registry.npmjs.org/semver/-/semver-6.3.1.tgz",
+      "integrity": "sha512-BR7VvDCVHO+q2xBEWskxS6DJE1qRnb7DxzUrogb71CWoSficBxYsiAGd+Kl0mmq/MprG9yArRkyrQxTO6XjMzA==",
       "dev": true,
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@@ -1597,9 +1597,9 @@
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     "node_modules/@babel/preset-env/node_modules/semver": {
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-      "resolved": "https://registry.npmjs.org/semver/-/semver-6.3.0.tgz",
-      "integrity": "sha512-b39TBaTSfV6yBrapU89p5fKekE2m/NwnDocOVruQFS1/veMgdzuPcnOM34M6CwxW8jH/lxEa5rBoDeUwu5HHTw==",
+      "version": "6.3.1",
+      "resolved": "https://registry.npmjs.org/semver/-/semver-6.3.1.tgz",
+      "integrity": "sha512-BR7VvDCVHO+q2xBEWskxS6DJE1qRnb7DxzUrogb71CWoSficBxYsiAGd+Kl0mmq/MprG9yArRkyrQxTO6XjMzA==",
       "dev": true,
       "bin": {
         "semver": "bin/semver.js"
@@ -2724,9 +2724,9 @@
       "dev": true
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     "node_modules/@jest/core/node_modules/semver": {
-      "version": "7.3.5",
-      "resolved": "https://registry.npmjs.org/semver/-/semver-7.3.5.tgz",
-      "integrity": "sha512-PoeGJYh8HK4BTO/a9Tf6ZG3veo/A7ZVsYrSA6J8ny9nb3B1VrpkuN+z9OE5wfE5p6H4LchYZsegiQgbJD94ZFQ==",
+      "version": "7.5.4",
+      "resolved": "https://registry.npmjs.org/semver/-/semver-7.5.4.tgz",
+      "integrity": "sha512-1bCSESV6Pv+i21Hvpxp3Dx+pSD8lIPt8uVjRrxAUt/nbswYc+tK6Y2btiULjd4+fnq15PX+nqQDC7Oft7WkwcA==",
       "dev": true,
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@@ -3935,9 +3935,9 @@
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-      "integrity": "sha512-PoeGJYh8HK4BTO/a9Tf6ZG3veo/A7ZVsYrSA6J8ny9nb3B1VrpkuN+z9OE5wfE5p6H4LchYZsegiQgbJD94ZFQ==",
+      "version": "7.5.4",
+      "resolved": "https://registry.npmjs.org/semver/-/semver-7.5.4.tgz",
+      "integrity": "sha512-1bCSESV6Pv+i21Hvpxp3Dx+pSD8lIPt8uVjRrxAUt/nbswYc+tK6Y2btiULjd4+fnq15PX+nqQDC7Oft7WkwcA==",
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@@ -4717,9 +4717,9 @@
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     "node_modules/@typescript-eslint/eslint-plugin/node_modules/semver": {
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@@ -4786,9 +4786,9 @@
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+      "version": "7.5.4",
+      "resolved": "https://registry.npmjs.org/semver/-/semver-7.5.4.tgz",
+      "integrity": "sha512-1bCSESV6Pv+i21Hvpxp3Dx+pSD8lIPt8uVjRrxAUt/nbswYc+tK6Y2btiULjd4+fnq15PX+nqQDC7Oft7WkwcA==",
       "dev": true,
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@@ -4884,9 +4884,9 @@
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     "node_modules/@typescript-eslint/typescript-estree/node_modules/semver": {
-      "version": "7.3.5",
-      "resolved": "https://registry.npmjs.org/semver/-/semver-7.3.5.tgz",
-      "integrity": "sha512-PoeGJYh8HK4BTO/a9Tf6ZG3veo/A7ZVsYrSA6J8ny9nb3B1VrpkuN+z9OE5wfE5p6H4LchYZsegiQgbJD94ZFQ==",
+      "version": "7.5.4",
+      "resolved": "https://registry.npmjs.org/semver/-/semver-7.5.4.tgz",
+      "integrity": "sha512-1bCSESV6Pv+i21Hvpxp3Dx+pSD8lIPt8uVjRrxAUt/nbswYc+tK6Y2btiULjd4+fnq15PX+nqQDC7Oft7WkwcA==",
       "dev": true,
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@@ -4972,9 +4972,9 @@
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     "node_modules/@typescript-eslint/utils/node_modules/semver": {
-      "version": "7.3.5",
-      "resolved": "https://registry.npmjs.org/semver/-/semver-7.3.5.tgz",
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+      "version": "7.5.4",
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+      "integrity": "sha512-BN22B5eaMMI9UMtjrGd5g5eCYPpCPDUy0FJXbYsaT5zYxjFOckS53SQDE3pWkVoWpHXVb3BrYcEN4Twa55B5cA==",
       "dev": true
     },
     "wrap-ansi": {
diff --git a/package.json b/package.json
index b0b712e..21c5389 100644
--- a/package.json
+++ b/package.json
@@ -1,6 +1,6 @@
 {
   "name": "@bcgsc-pori/graphkb-parser",
-  "version": "2.0.0",
+  "version": "2.1.0",
   "description": "A package for parsing and recreating HGVS-like variant notation used in GraphKB",
   "main": "dist/index.js",
   "types": "dist/index.d.ts",
diff --git a/src/error.ts b/src/error.ts
index 60f2a5a..2f5a3fe 100644
--- a/src/error.ts
+++ b/src/error.ts
@@ -55,4 +55,11 @@ class ParsingError extends ErrorMixin {}
 
 class InputValidationError extends ErrorMixin {}
 
-export { ParsingError, ErrorMixin, InputValidationError };
+class NotImplementedError extends ErrorMixin {}
+
+export {
+    ErrorMixin,
+    InputValidationError,
+    NotImplementedError,
+    ParsingError,
+};
diff --git a/src/variant.ts b/src/variant.ts
index 5d1b7ab..30360af 100644
--- a/src/variant.ts
+++ b/src/variant.ts
@@ -1,6 +1,10 @@
-import { ParsingError, InputValidationError } from './error';
+import { InputValidationError, ParsingError } from './error';
 import {
-    createPosition, createBreakRepr, convertPositionToJson, parsePosition, AnyPosition,
+    AnyPosition,
+    convertPositionToJson,
+    createBreakRepr,
+    createPosition,
+    parsePosition,
 } from './position';
 import {
     NOTATION_TO_TYPES,
@@ -43,7 +47,7 @@ interface VariantNotation {
     untemplatedSeqSize?: number;
     type: OntologyTerm | string;
     refSeq?: string | null;
-    prefix: Prefix;
+    prefix: Prefix | null;
     multiFeature: boolean;
     truncation?: number | null;
     notationType?: string;
@@ -80,7 +84,7 @@ const createVariantNotation = ({
     untemplatedSeqSize?: number | null;
     type: string;
     refSeq?: string | null;
-    prefix: Prefix;
+    prefix: Prefix | null;
     multiFeature?: boolean;
     truncation?: number;
     notationType?: string;
@@ -125,7 +129,14 @@ const createVariantNotation = ({
     // cast positions
     const formatPosition = (input) => {
         if (input !== null && input !== undefined) {
-            return createPosition(prefix, input);
+            let breakPrefix;
+
+            if (typeof input.prefix !== 'undefined') {
+                breakPrefix = input.prefix;
+            } else {
+                breakPrefix = prefix;
+            }
+            return createPosition(breakPrefix, input);
         }
         return input;
     };
@@ -203,7 +214,7 @@ const jsonifyVariant = (variant: VariantNotation): { [key: string]: string } =>
     return json;
 };
 
-const stringifyVariant = (variant: VariantNotation): string => {
+const stringifyVariant = (variant: VariantNotation, newFusion = false): string => {
     const {
         multiFeature,
         noFeatures,
@@ -230,7 +241,22 @@ const stringifyVariant = (variant: VariantNotation): string => {
         if (!break2Repr) {
             throw new InputValidationError('Multi-feature notation requires break2Repr');
         }
-        // multi-feature notation
+        // new fusion nomenclature notation
+        if (newFusion) {
+            let insertedSequence = '';
+
+            if (untemplatedSeq !== undefined && untemplatedSeq !== null) {
+                insertedSequence = `${untemplatedSeq}::`;
+            }
+
+            if (noFeatures) {
+                return `${break1Repr}::${insertedSequence}${break2Repr}`;
+            }
+
+            return `${reference1}:${break1Repr}::${insertedSequence}${reference2}:${break2Repr}`;
+        }
+
+        // multi-feature notation (incl. legacy fusion notation)
         let result = noFeatures
             ? ''
             : `(${reference1},${reference2}):`;
@@ -311,7 +337,7 @@ const parseMultiFeature = (string: string): {
     break2End?: AnyPosition,
     untemplatedSeqSize?: number | null,
     untemplatedSeq?: string | null,
-    prefix: Prefix,
+    prefix: Prefix | null,
 } => {
     if (string.length < 6) {
         throw new ParsingError(`Too short. Multi-feature notation must be a minimum of six characters: ${string}`);
@@ -379,29 +405,36 @@ const parseMultiFeature = (string: string): {
             violatedAttr: 'punctuation',
         });
     }
-    let prefix,
+    let break1Prefix,
+        break2Prefix,
         break1Start,
         break1End,
         break2Start,
         break2End;
 
     try {
-        prefix = getPrefix(positions[0]);
+        break1Prefix = getPrefix(positions[0]);
         positions[0] = positions[0].slice(2);
 
         if (positions[0].includes('_')) {
             const splitPos = positions[0].indexOf('_');
-            break1Start = parsePosition(prefix, positions[0].slice(0, splitPos));
-            break1End = parsePosition(prefix, positions[0].slice(splitPos + 1));
+            break1Start = parsePosition(break1Prefix, positions[0].slice(0, splitPos));
+            break1End = parsePosition(break1Prefix, positions[0].slice(splitPos + 1));
         } else {
-            break1Start = parsePosition(prefix, positions[0]);
+            break1Start = parsePosition(break1Prefix, positions[0]);
         }
     } catch (err) {
         throw new ParsingError({
             message: 'Error in parsing the first breakpoint position/range',
             input: string,
             parsed: {
-                type: variantType, break1Start, break1End, break2Start, break2End, untemplatedSeqSize, untemplatedSeq,
+                type: variantType,
+                break1Start,
+                break1End,
+                break2Start,
+                break2End,
+                untemplatedSeqSize,
+                untemplatedSeq,
             },
             subParserError: err,
             violatedAttr: 'break1',
@@ -409,32 +442,195 @@ const parseMultiFeature = (string: string): {
     }
 
     try {
-        prefix = getPrefix(positions[1]);
+        break2Prefix = getPrefix(positions[1]);
         positions[1] = positions[1].slice(2);
 
         if (positions[1].includes('_')) {
             const splitPos = positions[1].indexOf('_');
-            break2Start = parsePosition(prefix, positions[1].slice(0, splitPos));
-            break2End = parsePosition(prefix, positions[1].slice(splitPos + 1));
+            break2Start = parsePosition(break2Prefix, positions[1].slice(0, splitPos));
+            break2End = parsePosition(break2Prefix, positions[1].slice(splitPos + 1));
         } else {
-            break2Start = parsePosition(prefix, positions[1]);
+            break2Start = parsePosition(break2Prefix, positions[1]);
         }
     } catch (err) {
         throw new ParsingError({
             message: 'Error in parsing the second breakpoint position/range',
             input: string,
             parsed: {
-                type: variantType, break1Start, break1End, break2Start, break2End, untemplatedSeqSize, untemplatedSeq,
+                type: variantType,
+                break1Start,
+                break1End,
+                break2Start,
+                break2End,
+                untemplatedSeqSize,
+                untemplatedSeq,
             },
             subParserError: err,
             violatedAttr: 'break2',
         });
     }
+
+    // prefix
+    let prefix;
+
+    if (break1Prefix === break2Prefix) {
+        // Since each fusion part have it's own prefix, a prefix at the variant
+        // level is only given if they are the same
+        prefix = break1Prefix;
+    }
+
+    return {
+        type: variantType,
+        break1Start,
+        break1End,
+        break2Start,
+        break2End,
+        untemplatedSeqSize,
+        untemplatedSeq,
+        prefix: prefix || null,
+    };
+};
+
+/**
+ * Parse one side of a fusion variant using the new nomenclature (KBDEV-974)
+ *
+ * @param {string} string is one of the fusion part (one side) to be parsed
+ * @param {boolean} requireFeatures
+ *
+ * @returns {VariantNotation} the parsed content
+ */
+const parseFusionPart = (string, requireFeatures) => {
+    // Come from a multi-feature variant
+    const multiFeature = true;
+
+    // Feature vs Variant strings
+    const stringSplit = string.split(':');
+
+    if (stringSplit.length > 2) {
+        throw new ParsingError({
+            message: 'Variant notation must contain a single colon',
+            input: string,
+            violatedAttr: 'punctuation',
+        });
+    } else if (stringSplit.length === 1) {
+        if (!requireFeatures) {
+            stringSplit.unshift('');
+        } else {
+            throw new ParsingError({
+                message: 'Feature name not specified. Feature name is required',
+                violatedAttr: 'reference1',
+            });
+        }
+    }
+    const [featureString, variantString] = stringSplit;
+
+    // References
+    let reference1 = '';
+
+    if (featureString) {
+        reference1 = featureString;
+    }
+
+    // Prefix
+    const prefix = getPrefix(variantString);
+
+    // Range of positions
+    const positions = variantString.slice(prefix.length + 1).split('_');
+
+    if (positions.length !== 2) {
+        throw new ParsingError({
+            message: 'Fusion notation must be a range of positions',
+            input: string,
+        });
+    }
+
+    // Returns a partial variant notation for that variant's part
     return {
-        type: variantType, break1Start, break1End, break2Start, break2End, untemplatedSeqSize, untemplatedSeq, prefix,
+        reference1,
+        reference2: '',
+        type: NOTATION_TO_TYPES.fusion,
+        multiFeature,
+        prefix,
+        break1Start: parsePosition(prefix, positions[0]),
+        break1End: parsePosition(prefix, positions[1]),
     };
 };
 
+/**
+ * Parse a fusion variant using the new HGVS nomenclature (KBDEV-974)
+ *
+ * @param {string} string is a fusion variant using the new nomenclature
+ * @param {boolean} requireFeatures, if set to false, allows string without feature
+ *
+ * @returns {VariantNotation} the parsed content
+ */
+const parseFusion = (string, requireFeatures = true) => {
+    const parts = string.split('::');
+
+    if (parts.length > 3) {
+        throw new ParsingError({
+            message: 'Fusion variant using new nomenclature must contain 1 or 2 double-colon',
+            input: string,
+            violatedAttr: 'punctuation',
+        });
+    }
+
+    let untemplatedSeq,
+        untemplatedSeqSize;
+
+    // Special case with a sequence insertion between the 2 fusion parts
+    if (parts.length === 3) {
+        const [, insertion] = parts;
+
+        // When implemented, sequence insertion need to be in RNA
+        // if following HGVS standards restricting fusion to 'r' prefix
+        if (!/^[ACGU]+$/.test(insertion.toUpperCase())) {
+            throw new ParsingError({
+                message: 'Insertion sequence of fusion variant should be given in ribonucleotides',
+                input: string,
+                violatedAttr: 'alphabet',
+            });
+        }
+        untemplatedSeq = insertion.toUpperCase();
+        untemplatedSeqSize = insertion.length;
+    }
+
+    // Standard 2-parts fusion - Parsing individual parts
+    const t1 = parseFusionPart(parts[0], requireFeatures);
+    const t2 = parseFusionPart(parts[parts.length - 1], requireFeatures); // skip middle part if one
+
+    // Prefix
+    let prefix;
+
+    if (t1.prefix === t2.prefix) {
+        // Since each fusion part have it's own prefix, a prefix at the variant
+        // level is only given if they are the same
+        prefix = t1.prefix;
+    }
+
+    try {
+        return createVariantNotation({
+            ...t1,
+            prefix: prefix || null,
+            requireFeatures,
+            reference2: t2.reference1,
+            break2Start: t2.break1Start,
+            break2End: t2.break1End,
+            untemplatedSeq,
+            untemplatedSeqSize,
+        });
+    } catch (err: any) {
+        if (err.content) {
+            err.content.parsed = {
+                string,
+                reference1: t1.reference1,
+                reference2: t2.reference1,
+            };
+        }
+        throw err;
+    }
+};
+
 /**
  * Parse variant shorthand. Checks and validates notation
  *
@@ -449,10 +645,15 @@ const parseVariant = (string, requireFeatures = true) => {
             input: string,
         });
     }
+    // New fusion nomenclature handling (KBDEV-974)
+    if (string.split('::').length > 1) {
+        return parseFusion(string, requireFeatures);
+    }
+    // Feature vs Variant strings
     const split = string.split(':');
 
     if (split.length > 2) {
-        throw new ParsingError({ message: 'Variant notation must contain a single colon', input: string, violatedAttr: 'punctuation' });
+        throw new ParsingError({ message: 'Apart from new fusion nomenclature, variant notation must contain a single colon', input: string, violatedAttr: 'punctuation' });
     } else if (split.length === 1) {
         if (!requireFeatures) {
             split.unshift(null);
diff --git a/test/index.test.ts b/test/index.test.ts
index 25a091d..2f2476f 100644
--- a/test/index.test.ts
+++ b/test/index.test.ts
@@ -153,7 +153,7 @@ test.each([
     ['12:y.q13_q14insATCG', 'cannot define sequence elements (untemplatedSeq) at the cytoband level'],
     ['FEATURE:f.G12D', 'not an accepted prefix'],
     ['FEATURE:pG12D', 'Missing \'.\' separator after prefix'],
-    ['FEATURE:OTHER:pG12D', 'Variant notation must contain a single colon'],
+    ['FEATURE:OTHER:pG12D', 'Apart from new fusion nomenclature, variant notation must contain a single colon'],
     ['FEATURE:p.G12_HH13insH', 'Failed to parse the initial position'],
     ['p.G12K', 'Feature name not specified'],
     ['(,):()', 'Multi-feature notation must be a minimum of six characters'],
diff --git a/test/variant.test.ts b/test/variant.test.ts
index 6ad21b6..7ecf47d 100644
--- a/test/variant.test.ts
+++ b/test/variant.test.ts
@@ -1,3 +1,4 @@
+import data from '../data/variants';
 import {
     stringifyVariant,
     stripParentheses,
@@ -8,7 +9,7 @@ import {
 import { createPosition } from '../src/position';
 import { NOTATION_TO_TYPES } from '../src/constants';
 
-describe('VariantNotation', () => {
+describe('createVariantNotation', () => {
     test('use object name if no sourceId on reference', () => {
         const notation = createVariantNotation({
             reference1: { name: 'KRAS' },
@@ -159,3 +160,28 @@ describe('jsonifyVariant', () => {
         });
     });
 });
+
+describe('parseVariant & stringifyVariant', () => {
+    const variants = {
+        ...data.standardVariants,
+        ...data.legacyNomenclatureFusionVariants,
+        ...data.newNomenclatureFusionVariants,
+    };
+
+    test.each(Object.keys(variants))('Parsing and stringifying back %s', (variantString) => {
+        const variantNotation = parseVariant(variantString);
+
+        // Parse variant string and compare notations
+        expect(variantNotation).toStrictEqual(
+            expect.objectContaining({
+                ...variants[variantString],
+                break1Start: expect.objectContaining(
+                    variants[variantString].break1Start,
+                ),
+            }),
+        );
+        // Strignify notation and compare variant strings
+        const newFusion = variantString.split('::').length > 1;
+        expect(stringifyVariant(variants[variantString], newFusion)).toBe(variantString);
+    });
+});