diff --git a/recipes/dram/fix_setup.patch b/recipes/dram/fix_setup.patch
new file mode 100644
index 0000000000000..f8fb0fcc6f255
--- /dev/null
+++ b/recipes/dram/fix_setup.patch
@@ -0,0 +1,14 @@
+--- scripts/DRAM-setup.py.old	2024-03-24 22:09:07.980198244 -0500
++++ scripts/DRAM-setup.py	2024-03-24 22:10:39.107097364 -0500
+@@ -121,10 +121,10 @@
+                                     help='vog annotations file') # add loc to vog_annotations to match the rest
+ 
+     set_db_locs_parser.add_argument('--viral_loc', default=None,
++                                    help='mmseqs2 database file from ref seq viral gene collection')
+     set_db_locs_parser.add_argument('--camper_tar_gz_loc', default=None,
+                                     help='The source for the CAMPER database files, this is a tar.gz file downloaded'
+                                     ' from the release page https://github.com/WrightonLabCSU/CAMPER/releases')
+-                                    help='mmseqs2 database file from ref seq viral gene collection')
+     set_db_locs_parser.add_argument('--peptidase_loc', default=None,
+                                     help='mmseqs2 database file from MEROPS database')
+     set_db_locs_parser.add_argument('--description_db_loc', default=None,
diff --git a/recipes/dram/meta.yaml b/recipes/dram/meta.yaml
index 6c93600ad8052..71f440a076c1b 100644
--- a/recipes/dram/meta.yaml
+++ b/recipes/dram/meta.yaml
@@ -1,7 +1,7 @@
 {% set name = "DRAM" %}
 {% set pypi_name = "DRAM-bio" %}
-{% set version = "1.4.6" %}
-{% set sha256 = "f014c55d7e75433bfc029dc20092df6eb9fb5a565dc60d6e7934d0261f36f945" %}
+{% set version = "1.5.0" %}
+{% set sha256 = "2d4a503fa806e33b580afb6d21879b2399178e48ba3b05ada882449fee571889" %}
 
 package:
   name: {{ name|lower }}
@@ -10,15 +10,20 @@ package:
 source:
   url: https://pypi.io/packages/source/{{ name[0] }}/{{ pypi_name }}/{{ pypi_name }}-{{ version }}.tar.gz
   sha256: {{ sha256 }}
+  patches:
+    # https://github.com/WrightonLabCSU/DRAM/issues/339
+    - fix_setup.patch
 
 build:
-  number: 2
+  number: 0
   noarch: python
   script: "{{ PYTHON }} -m pip install . -vv"
+  run_exports:
+    - {{ pin_subpackage(name|lower, max_pin="x") }}
 
 requirements:
   host:
-    - python >=3.6
+    - python >=3.8
     - pip
   run:
     - python >=3.8