- parallelization with patches of bam - for example, split bam into 20 sections if 20 cores available - both options: **concatenate** vs. **run analysis on regions** Example: - get whole genome reference, produce BAM from it - run, in parallel, a task on each chromosome - for each chromosome task, after its done do further analysis AND - after all chromosomes finish, do something that needs all of them (e.g. GWAS)
Example: